Immune Dysfunction and Nontuberculous Mycobacterial Disease

Henkle, Emily; Winthrop, Kevin

doi:10.1007/978-3-319-93473-0_5

Cited by 4 publications

(5 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other acquired states of immune deficiency, such as haematopoietic stem cell transplantation and solid organ transplantation are also predisposed to NTM infection. However, these patients could present with PNTM, DNTM, or other extra pulmonary sites of NTM infection (23). Other specific PIDs like Severe Combined Immune Deficiency (SCID) are commonly associated with BCGiosis, while Common Variable Immune Deficiency (CVID) predisposes patients to bronchiectasis which, in-turn, can lead to PTNM infection (21).…”

Section: Risk Groups For Ntm Diseasementioning

confidence: 99%

“…Finally, gastro-esophageal reflux disease (GORD), vitamin D deficiency, rheumatoid arthritis (26,32,33) and low body mass index (BMI) are art risk of NTM lung disease (34). The acquire and genetic risk factors for NTM infection, both PNTM and DNTM are discussed in a recent reviews by Honda et al (35) and Henkle et al (23) showing the many forms and known susceptibilities the disease takes.…”

Section: Risk Groups For Ntm Diseasementioning

confidence: 99%

See 1 more Smart Citation

The Rise of Non-Tuberculosis Mycobacterial Lung Disease

et al. 2020

View full text Add to dashboard Cite

Section: Risk Groups For Ntm Diseasementioning

confidence: 99%

Section: Risk Groups For Ntm Diseasementioning

confidence: 99%

The Rise of Non-Tuberculosis Mycobacterial Lung Disease

et al. 2020

View full text Add to dashboard Cite

“…The incidences of non-tuberculous mycobacterial lung diseases have increased over the past decades in several parts of the world, including the United States. 6,7…”

Section: Introductionmentioning

confidence: 99%

Evaporation of bacteria-laden surrogate respiratory fluid droplets: On a hydrophilic substrate versus contact-free environment confers differential bacterial infectivity

Agharkar,

Hajra,

Roy

et al. 2024

Preprint

View full text Add to dashboard Cite

The transmission of viruses/ bacteria cause infection predominantly via aerosols. The transmission mechanism of respiratory diseases is complex, including direct or indirect contact, large droplet, and airborne routes apart from close contact transmission. With this pretext, we have investigated two modes of droplet evaporation to understand its significance in airborne disease transmission; a droplet in a contact-free environment, which evaporates and forms droplet nuclei, and a droplet on a hydrophilic substrate (fomite). The study examines mass transport, the deposition pattern of bacteria in the precipitates, and their survival and virulence. The osmotic pressure increases with the salt concentration, inactivating the bacteria embedded in the precipitates with accelerated evaporation. Further, the bacteria's degree of survival and enhanced pathogenicity are compared for both evaporation modes. The striking differences in pathogenicity are attributed to the evaporation rate, oxygen availability, and reactive oxygen species (ROS) generation.

show abstract

“…These include patients with genetic or acquired structural lung diseases such as cystic fibrosis, chronic obstructive pulmonary disease, bronchiectasis, alpha-1-antitrypsin deficiency, tuberculosis and lung cancer, pulmonary fibrosis, and pneumoconiosis [ 10 ]. Patients with immunosuppression due to primary [ 11 ] and acquired immunodeficiency syndromes that accompany HIV infection and hematologic malignancies, and patients receiving systemic glucocorticosteroid or cytostatic therapy are also susceptible to NTM infection [ 12 ]. The clinical significance of NTM detection in the verification of infectious complications in cardiothoracic and aesthetic surgery has been observed [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Variability of Mycobacterium avium Complex Isolates Drug Susceptibility Testing by Broth Microdilution

Zimenkov

2022

Antibiotics

View full text Add to dashboard Cite

Non-tuberculous mycobacteria are widely distributed in environments and are capable of infecting humans, particularly those with a compromised immune system. The most prevalent species that cause nontuberculous mycobacterial lung diseases are slow-growing bacteria from the Mycobacterium avium complex (MAC), mainly M. avium or M. intracellulare. The key treatment of MAC infections includes macrolides, ethambutol, and rifampicin; however, the therapy outcomes are unsatisfactory. Phenotypic drug susceptibility testing is a conditional recommendation prior to treatment, and critical concentrations for clarithromycin, amikacin, moxifloxacin, and linezolid have been established. In this review, data from studies on the determination of MIC of clinical isolates using the broth microdilution method were summarized. A significant variation in the MIC distributions from different studies was found. The main reasons could impact the findings: insufficient reproducibility of the phenotypic testing and variation in species lineages identified in different laboratories, which could have various intrinsic susceptibility to drugs. For most of the drugs analyzed, the MICs are too high, which could undermine the treatment efficiency. Further improvement of treatment outcomes demands the validation of microbiological resistance criteria together with the identification of molecular mechanisms of resistance.

show abstract

Immune Dysfunction and Nontuberculous Mycobacterial Disease

Cited by 4 publications

References 82 publications

The Rise of Non-Tuberculosis Mycobacterial Lung Disease

The Rise of Non-Tuberculosis Mycobacterial Lung Disease

Evaporation of bacteria-laden surrogate respiratory fluid droplets: On a hydrophilic substrate versus contact-free environment confers differential bacterial infectivity

Variability of Mycobacterium avium Complex Isolates Drug Susceptibility Testing by Broth Microdilution

Contact Info

Product

Resources

About