Immune Deviation and Alleviation of Allergic Reactions in Mice Subjected to Dietary Restriction

Yamazaki, Ken-ichi; Kato-Nagaoka, Noriko; Suzuki, Tomomi; Shida, Katsunori; Nanno, Masanobu

doi:10.1271/bbb.90561

Cited by 2 publications

(4 citation statements)

References 29 publications

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“…In experimental animal studies, fasting protected or diminished the distress level of autoimmune disease and allergy [5–7]. In clinical studies, fasting [15] and a low-calorie diet [16] have been reported to be effective in patients with rheumatoid arthritis.…”

Section: Discussionmentioning

confidence: 99%

“…A review study found that one randomized trial concluded that weight loss may have some benefits for relieving asthma in overweight and obese patients [17]. Other studies indicated that fasting and DR can protect the increase of allergen-specific IL-4-producing T cells and suppress the allergic reaction [5] and in humans can ameliorate T-cell function [18]. …”

Section: Discussionmentioning

confidence: 99%

“…Among the various methods for detoxification, fasting has an inhibitory effect on allergic dermatitis in experimental mouse models [5–7]. Furthermore, a clinical study has suggested a positive relationship between weight loss through repeated short-term fasting and symptom improvement in patients with AD [8].…”

Section: Introductionmentioning

confidence: 99%

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Detoxification Combining Fasting with Fluid Therapy for Refractory Cases of Severe Atopic Dermatitis

Kim

Nam

2013

Evidence-Based Complementary and Alternative Medicine

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To introduce and determine the clinical benefits of a detoxification program that combines fasting with fluid therapy for refractory cases of severe atopic dermatitis (AD), we performed a retrospective chart review of inpatients with AD from March 2010 to February 2012 at the Department of Ophthalmology, Otorhinolaryngology and Dermatology of Korean Medicine in the Kyung Hee Medical Center. Patients were treated with the detoxification program, which combined fasting with fluid therapy, and herbal medicine, herbal wet wrap dressings, or acupuncture treatment when clinically necessary. The primary outcome was the SCORAD total index. The secondary outcome was the pruritus visual analogue scale (VAS) score in SCORAD as evaluated by a trained dermatology specialist. Among the 130 inpatients that have done detoxification, 7 patients met the inclusion criteria. The mean total SCORAD scores significantly decreased from 64.67 ± 11.72 to 26.26 ± 11.01 (P = 0.018) after the detoxification program. There was also a significant decrease in VAS score for pruritus from 8.00 ± 1.16 to 2.57 ± 0.98 (P = 0.016) between admission and discharge. We suggest that fasting with fluid therapy as a complementary and alternative treatment method may provide some benefits for patients with refractory cases of severe atopic dermatitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Detoxification Combining Fasting with Fluid Therapy for Refractory Cases of Severe Atopic Dermatitis

Kim

Nam

2013

Evidence-Based Complementary and Alternative Medicine

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“…[19] Anti-CD3 antibodies are commonly used in the laboratory for T-cell activating and proliferation, [20,21] but the widespread and indiscriminate activation makes them difficult to apply in vivo due to the risk of dangerous immune storm. [22,23] Therefore, new methods of T-cell activation need to be sought. Antigen recognition requires direct physical contact between T cells and antigen presenting cells (APCs).…”

Section: Introductionmentioning

confidence: 99%

Mechanical Activation of Immune T Cells via a Water Driven Nanomotor

Xie

et al. 2022

Adv Healthcare Materials

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As a key step during immune response, antigen recognition requires direct mechanical interaction between T cells and antigen presenting cells. Upon subjection to mechanical forces, mechanotransduction is triggered. In this study, the mechanical forces generated by water driven synthetic Au-Zn nanomotors are used to activate mechanosensitive Jurkat T cells. The triggering and activation of the cellular Ca 2+ channel is observed. It is revealed that the mechanosensitive cells experience different degrees of activation upon receiving different mechanical input signals and demonstrate that external mechanical forces can optimize T cell activation. Compared with T cell activation with cytokines which can lead to the risky widespread activation of T cells and systemic immune storm, nanomotors can present mechanical force and achieve localized immune cell stimulation. It is expected that mechano nanomotors will contribute to the emerging T cell immunology field and facilitate more comprehensive understanding of the T cell mechanical response and function.

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Immune Deviation and Alleviation of Allergic Reactions in Mice Subjected to Dietary Restriction

Cited by 2 publications

References 29 publications

Detoxification Combining Fasting with Fluid Therapy for Refractory Cases of Severe Atopic Dermatitis

Detoxification Combining Fasting with Fluid Therapy for Refractory Cases of Severe Atopic Dermatitis

Mechanical Activation of Immune T Cells via a Water Driven Nanomotor

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