Immune destruction of virus-infected cells early in the infectious cycle

Shore, Steven L.; Cromeans, Theresa L.; Romano, Thomas J.

doi:10.1038/262695a0

Cited by 62 publications

(32 citation statements)

References 7 publications

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“…The ADCC process has been found to be active in destroying herpesvirus-infected cells early after virus transmission (1095). Whether ADCC is relevant clinically in HIV infection is not known; conflicting data on its association with an asymptomatic state have been presented (284,708,709,1047).…”

Section: A Neutralizing Antibodiesmentioning

confidence: 99%

Pathogenesis of Human Immunodeficiency Virus Infection

Levy¹

1989

Annals of the New York Academy of Sciences

222

290

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Section: A Neutralizing Antibodiesmentioning

confidence: 99%

Pathogenesis of Human Immunodeficiency Virus Infection

Levy¹

1989

Annals of the New York Academy of Sciences

222

290

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“…Antibodies either alone or in conjunction with complement components can neutralize the infectious virus. Antibodymediated complement-dependent responses (Oldstone & Lampert, 1979) or antibodydependent cellular cytotoxicity (Shore et al, 1976) can result in lysis of virus-infected cells. These mechanisms are believed to play an important role in the recovery from virus infection.…”

Section: Pathogenesis Of Herpes Simplex Virus In B Cell-suppressed MImentioning

confidence: 99%

Pathogenesis of Herpes Simplex Virus in B Cell-suppressed Mice: the Relative Roles of Cell-mediated and Humoral Immunity

Kapoor¹,

Nash

Wildy

1982

Journal of General Virology

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“…Ab-dependent cellular cytotoxicity (ADCC) 4 as well as CTL play an important role in protective immunity against viral infections (6,7). ADCC can inhibit viral replication and cell-to-cell infection by killing HIV-1-infected cells before maturation of virus particles (8,9).…”

mentioning

confidence: 99%

Antibody-Dependent Cellular Cytotoxicity via Humoral Immune Epitope of Nef Protein Expressed on Cell Surface

Yamada

Watanabe²,

Nakamura

et al. 2004

The Journal of Immunology

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Antibodies against various proteins of HIV type 1 (HIV-1) can be detected in HIV-1-infected individuals. We previously reported that the level of Ab response against one Nef epitope is correlated with HIV-1 disease progression. To elucidate the mechanism for this correlation, we examined Ab-dependent cellular cytotoxicity (ADCC) against target cells expressing Nef. We observed efficient cytotoxicity against Nef-expressing target cells in the presence of patient plasma and PBMCs. This ADCC activity was correlated with the dilution of plasma from HIV-1-infected patients. Addition of a specific synthetic peptide (peptide 31:FLKEKGGLE) corresponding to the Nef epitope reduced cell lysis to ∼50%. These results suggest that PBMCs of HIV-1-infected patients may exert ADCC via anti-Nef Abs in the patients’ own plasma and serve as a mechanism used by the immune system to regulate HIV-1 replication.

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Immune destruction of virus-infected cells early in the infectious cycle

Cited by 62 publications

References 7 publications

Pathogenesis of Human Immunodeficiency Virus Infection

Pathogenesis of Human Immunodeficiency Virus Infection

Pathogenesis of Herpes Simplex Virus in B Cell-suppressed Mice: the Relative Roles of Cell-mediated and Humoral Immunity

Antibody-Dependent Cellular Cytotoxicity via Humoral Immune Epitope of Nef Protein Expressed on Cell Surface

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