Immune Complexes in Systemic Lupus Erythematosus

Wener, Mark H.

doi:10.1016/b978-0-12-801917-7.00026-7

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…In a vicious cycle, these immune complexes persist, are immunogenic via interaction with complement components and leukocytes, and perpetuate disease by causing further kidney damage and generating more immune complexes. Although we cannot support this model by comparing it to any documented disease in fishes, immune complexes can cause localized and systemic diseases in humans as exemplified by complement deficiency, systemic lupus erythematosus and immune complex nephritis ( 48 – 50 ). In contrast to humans and these chronic diseases however, the kidney of teleost fishes is hematopoietic and erythropoietic, making it plausible that the course and severity of disease are accelerated and exacerbated.…”

Section: Discussionmentioning

confidence: 91%

Red blood cells in proliferative kidney disease—rainbow trout (Oncorhynchus mykiss) infected by Tetracapsuloides bryosalmonae harbor IgM+ red blood cells

et al. 2023

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The myxozoan parasite Tetracapsuloides bryosalmonae is the causative agent of proliferative kidney disease (PKD)—a disease of salmonid fishes, notably of the commercially farmed rainbow trout Oncorhynchus mykiss. Both wild and farmed salmonids are threatened by this virulent/deadly disease, a chronic immunopathology characterized by massive lymphocyte proliferation and hyperplasia, which manifests as swollen kidneys in susceptible hosts. Studying the immune response towards the parasite helps us understand the causes and consequences of PKD. While examining the B cell population during a seasonal outbreak of PKD, we unexpectedly detected the B cell marker immunoglobulin M (IgM) on red blood cells (RBCs) of infected farmed rainbow trout. Here, we studied the nature of this IgM and this IgM+ cell population. We verified the presence of surface IgM via parallel approaches: flow cytometry, microscopy, and mass spectrometry. The levels of surface IgM (allowing complete resolution of IgM- RBCs from IgM+ RBCs) and frequency of IgM+ RBCs (with up to 99% of RBCs being positive) have not been described before in healthy fishes nor those suffering from disease. To assess the influence of the disease on these cells, we profiled the transcriptomes of teleost RBCs in health and disease. Compared to RBCs originating from healthy fish, PKD fundamentally altered RBCs in their metabolism, adhesion, and innate immune response to inflammation. In summary, RBCs play a larger role in host immunity than previously appreciated. Specifically, our findings indicate that the nucleated RBCs of rainbow trout interact with host IgM and contribute to the immune response in PKD.

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Section: Discussionmentioning

confidence: 91%

Red blood cells in proliferative kidney disease—rainbow trout (Oncorhynchus mykiss) infected by Tetracapsuloides bryosalmonae harbor IgM+ red blood cells

et al. 2023

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“…Immune complexes (ICs), which are a direct consequence of recognising self-molecules, are one of the main sources of this immune dysregulation. 26 Following deposition in a tissue endothelium, ICs trigger inflammation in different ways: first, they activate the complement system, which leads to tissue damage and cellular death; this releases nuclear material, such as nucleic acids, and generates cell debris as a source of autoantigens. 27 Then, ICs formed by Acs bound to nucleic acids and their associated proteins lead to the opsonisation of those autoantigens.…”

Section: Discussionmentioning

confidence: 99%

“… 32 ICs stimulate macrophages and monocytes to produce and secrete proinflammatory mediators such as MCP-1 and TNF-α, among others, as well as clearance of ICs by macrophages. 26 …”

Section: Discussionmentioning

confidence: 99%

Assessment of the role of high-density lipoproteins and their immunomodulatory activity in systemic lupus erythematosus immunopathology

Pérez-Ocampo,

Vergara-Serpa,

Velásquez-Franco

et al. 2024

Lupus Sci Med

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ObjectiveTo explore the potential associations between high-density lipoprotein (HDL) levels and inflammasome components in the context of systemic lupus erythematosus (SLE).MethodsA cross-sectional study was conducted. A group of 50 patients with SLE and 50 healthy controls matched by sex and similar age ranges were enrolled. Serum HDL cholesterol (HDL-C) and C reactive protein (CRP) levels were quantified. Serum cytokine levels, including IL-1β and IL-6, were determined by ELISA. The gene expression of inflammasome-related genes in peripheral blood mononuclear cells was measured by quantitative real-time PCR.ResultsHDL-C levels were lower in the patients with SLE (p<0.05), and on segregation according to disease activity, those with active SLE had the lowest HDL-C levels. Patients with SLE presented higher concentrations of the serum inflammatory cytokines IL-1β and IL-6 (p<0.0001) but similar levels of CRP to those in controls. A similar scenario was observed for the gene expression of inflammasome components, where all the evaluated markers were significantly upregulated in the SLE population. These results revealed significant negative correlations between HDL levels and disease activity, serum IL-6 and IL-1β levels and the mRNA expression of NLRP3, IL-1β and IL-18. In addition, significant positive correlations were found between disease activity and serum IL-1β and between disease activity and the mRNA expression of IL-18, and interestingly, significant positive correlations were also observed between active SLE and serum IL-1β and the mRNA expression of NLRP3.ConclusionOur results suggest that HDL is essential for SLE beyond atherosclerosis and is related to inflammation regulation, possibly mediated by inflammasome immunomodulation.

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The role of tolerogenic dendritic cells in systematic lupus erythematosus progression and remission

Mohammadi

Saghafi

Faraj

et al. 2023

International Immunopharmacology

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Immune Complexes in Systemic Lupus Erythematosus

Cited by 6 publications

References 34 publications

Red blood cells in proliferative kidney disease—rainbow trout (Oncorhynchus mykiss) infected by Tetracapsuloides bryosalmonae harbor IgM+ red blood cells

Red blood cells in proliferative kidney disease—rainbow trout (Oncorhynchus mykiss) infected by Tetracapsuloides bryosalmonae harbor IgM+ red blood cells

Assessment of the role of high-density lipoproteins and their immunomodulatory activity in systemic lupus erythematosus immunopathology

The role of tolerogenic dendritic cells in systematic lupus erythematosus progression and remission

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