Immune complex myositis associated with viral hepatitis

Damjanov, Ivan; Moser, Robert L.; Katz, Sheila Moriber; Lyons, Patricia

doi:10.1016/s0046-8177(80)80058-x

Cited by 15 publications

(5 citation statements)

References 10 publications

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“…Although the etiology of these extrahepatic manifestations has been linked to immune complex disease, the pathogenesis of these HBV-related disorders is poorly understood (1,2). Evidence for HBV-related immune complex circulation (3) and deposition has been demonstrated in patients with HBV infection and glomerulonephritis (4,5), PAN (6, 7), polymyositis (8), and arthritis (9). However, detection of HBV-related immune complexes has been inconsistent in different studies (10), their presence in the circulation is not always associated with extrahepatic disease (11), and end-organ disease can occur even in the absence of immune complex deposition (12).…”

Section: Introductionmentioning

confidence: 99%

“…Although extrahepatic deposition of hepatitis B antigenantibody immune complexes has been demonstrated in patients with a variety of HBV-related extrahepatic syndromes (3)(4)(5)(6)(7)(8)(9), their presence is not consistently associated with extrahepatic disease (10)(11)(12), and the process by which immunecomplex-mediated tissue injury occurs has not been convincingly established.…”

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confidence: 99%

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Hepatitis B Virus Replication in Damaged Endothelial Tissues of Patients with Extrahepatic Disease

Mason

Theal²,

Bain³

et al. 2005

Am J Gastroenterology

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Hepatitis B virus (HBV) infection may be complicated by extrahepatic manifestations such as polyarteritis nodosa (PAN), glomerulonephritis, polymyositis, and dermatitis, but the etiology of these processes is not yet clear. HBV replication has been demonstrated in a variety of extrahepatic tissues and cell types, but the possible pathogenetic role of extrahepatic HBV replication has not been fully explored in patients with extrahepatic manifestations of HBV infection. In this case series, immunohistochemistry and in situ hybridization studies were performed on extrahepatic tissues from one HBsAg-positive patient with PAN and another HBsAg-positive patient with polymyositis, using HBsAg-seronegative control subjects with the same vasculitic disorders as controls. Tissue samples from the two study patients had detectable HBV RNA, replicative intermediates of HBV DNA, as well as HBsAg and HBcAg localized to vascular endothelium. In contrast, HBsAg-negative control patients had no tissue reactivity. Our results suggest that patients with HBV-related extrahepatic disease have evidence of viral replication in damaged extrahepatic endothelial tissues. While further studies would be required to support a hypothesis of causality, these findings suggest a role for both immune complex deposition and viral replication within diseased endothelial tissue in the pathogenesis of these poorly understood extrahepatic disorders.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Hepatitis B Virus Replication in Damaged Endothelial Tissues of Patients with Extrahepatic Disease

Mason

Theal²,

Bain³

et al. 2005

Am J Gastroenterology

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“…Others also have concluded that malakoplakia probably represents a morphologic manifestation of altered host macrophage response and that gram-negative enteric bacilli may be the most common aetiologic agent (Lou and Teplitz, 1974). It is important to point out that bacteria other than gram-negative enterics have been associated with malakoplakia (Damjanov and Katz, 1981).…”

Section: Discussionmentioning

confidence: 99%

“…Malakoplakia has been reported to have three phases: early (prediagnostic), classic, and fibrosing (Damjanov and Katz, 1981). The earliest phase consists of plasma cells and occa-sional macrophages.…”

Section: Discussionmentioning

confidence: 99%

Malakoplakia of the parotid gland

Dale

Robinson

1988

J. Laryngol. Otol.

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“…It has been suggested that the infection induces the expression of MHC-1, which makes the infected fibres susceptible to an immune-mediated response. Other investigations conducted on muscle biopsies of PM cases have been less informative 116,[118][119][120].…”

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confidence: 99%

Blood‐borne viruses and neurological manifestations: An overview

Xu,

2024

Reviews in Medical Virology

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Infections caused by blood‐borne viruses, such as human immunodeficiency virus (HIV), human T‐lymphotropic virus (HTLV), hepatitis C virus (HCV), and hepatitis B virus (HBV), are systemic diseases that can lead to a wide range of pathological manifestations. Besides causing severe immune and hepatic disorders, these viral pathogens can also induce neurological dysfunctions via both direct and indirect mechanisms. Neurological dysfunctions are one of the most common manifestations caused by these viruses that can also serve as indicators of their infection, impacting the clinical presentation of the disease. The main neurological manifestations of these blood‐borne viral pathogens consist of several central and peripheral nervous system (CNS and PNS, respectively) dysfunctions. The most common neurological manifestations of HIV, HTLV, HCV, and HBV include HIV‐associated peripheral neuropathy (PN), HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP), and HCV‐/HBV‐associated PN, respectively. Nonetheless, patients infected with these viruses may experience other neurological disorders, either associated with these conditions or manifesting in isolation, which can often go unnoticed or undiagnosed by physicians. The present review aims to provide an overview of the latest evidence on the relationship between blood‐borne viruses and neurological disorders to highlight neurological conditions that may be somewhat overlooked by mainstream literature and physicians.

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Immune complex myositis associated with viral hepatitis

Cited by 15 publications

References 10 publications

Hepatitis B Virus Replication in Damaged Endothelial Tissues of Patients with Extrahepatic Disease

Hepatitis B Virus Replication in Damaged Endothelial Tissues of Patients with Extrahepatic Disease

Malakoplakia of the parotid gland

Blood‐borne viruses and neurological manifestations: An overview

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