“…All included studies assessed the relationship between the presence of irAEs and prognosis (12 of them examined the effect of irAE grades ( 14 , 37 , 45 , 57 , 58 , 68 , 71 , 73 , 76 , 82 , 84 , 85 )), 18 studies assessed endocrine irAEs (any, thyroiditis, or hypophysitis) ( 32 , 34 , 44 , 46 – 48 , 51 , 55 , 56 , 60 , 68 – 70 , 73 , 76 , 78 , 81 , 85 ), five assessed pulmonary irAEs ( 32 , 34 , 46 , 56 , 76 ), 21 assessed skin irAEs (any, rash, or vitiligo) ( 32 , 34 , 38 , 40 , 42 , 46 – 48 , 51 , 53 , 54 , 56 , 62 – 64 , 73 , 74 , 76 , 79 , 81 , 85 ), nine assessed gastrointestinal irAEs (any, colitis, or diarrhea) ( 32 , 34 , 46 , 56 , 58 , 73 , 76 , 77 , 85 ), and five assessed hepatic irAEs ( 32 , 34 , 36 , 76 , 85 …”