Immune Checkpoint Inhibitor–Associated Remitting Seronegative Symmetrical Synovitis With Pitting Edema: Description of a New Entity by CanRIO
Azin Rouhi,
Shahin Jamal,
Lourdes Gonzales Arreola
et al.
Abstract:ObjectiveRemitting seronegative symmetrical synovitis with pitting edema (RS3PE) is characterized by symmetrical synovitis with pitting edema and negative rheumatoid factor (RF). It has been described in setting of malignancy, suggesting a paraneoplastic association. With the increasing use of immune checkpoint inhibitors (ICIs) for the treatment of cancers and emergence of immune related adverse event (irAEs), our objective was to identify and describe cases of ICI associated RS3PE (ICI-RS3PE) and compare to … Show more
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