Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy

Xu, Li; Yu, Lei; Li, Jinke; Du, Weixing; Li, Rugui; Yang, Jing; Li, Jian; Li, Fang; Tan, Huabing

doi:10.1016/j.canlet.2019.11.009

Cited by 822 publications

(558 citation statements)

References 102 publications

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“…Reshaping TME provides a niche for interaction between tumor cells and surrounding fibroblasts, endothelial cells, and immune cells [4,[6][7][8][9]. These cells interact with tumor cells through TME to induce a variety of biological events, such as appreciation, migration, angiogenesis, immunosuppression, and drug resistance for tumor development [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Exosomal miRNAs in tumor microenvironment

Tan

Xia

et al. 2020

J Exp Clin Cancer Res

115

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Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as exosomes and cytokines. Exosomes are tiny extracellular vesicles (40-160nm) containing active substances, such as proteins, lipids and nucleic acids. Exosomes carry biologically active miRNAs to shuttle between tumor cells and TME, thereby affecting tumor development. Tumor-derived exosomal miRNAs induce matrix reprogramming in TME, creating a microenvironment that is conducive to tumor growth, metastasis, immune escape and chemotherapy resistance. In this review, we updated the role of exosomal miRNAs in the process of TME reshaping.

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Section: Introductionmentioning

confidence: 99%

Exosomal miRNAs in tumor microenvironment

Tan

Xia

et al. 2020

J Exp Clin Cancer Res

115

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“…Indeed, immune cell populations are conditioned by soluble factors, enzymes and metabolites produced by nearby tumor and stromal cells within the tumor microenvironment (TME) that contribute to dampen the antitumor immune response [4]. Moreover, the immunosuppressive TME can even shape immune cell functions toward a tumor-promoting response [5].…”

Section: Introductionmentioning

confidence: 99%

Shaping the Innate Immune Response by Dietary Glucans: Any Role in the Control of Cancer?

Cornò

Gessani

Conti

2020

Cancers

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β-glucans represent a heterogeneous group of naturally occurring and biologically active polysaccharides found in many kinds of edible mushrooms, baker’s yeast, cereals and seaweeds, whose health-promoting effects have been known since ancient times. These compounds can be taken orally as food supplements or as part of daily diets, and are safe to use, nonimmunogenic and well tolerated. A main feature of β-glucans is their capacity to function as biological response modifiers, exerting regulatory effects on inflammation and shaping the effector functions of different innate and adaptive immunity cell populations. The potential to interfere with processes involved in the development or control of cancer makes β-glucans interesting candidates as adjuvants in antitumor therapies as well as in cancer prevention strategies. Here, the regulatory effects of dietary β-glucans on human innate immunity cells are reviewed and their potential role in cancer control is discussed.

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“…In recent years, the key topics on cancer research have transferred from focusing on the tumour itself to studying the interaction between the tumour and its surrounding environment, which is commonly referred to tumour microenvironment (TME). Tumour microenvironment, where the tumour cells arise and live, includes not only the tumour cells themselves, but also their surrounding stroma, microvasculature, and a variety of cells including immune cells, stromal cells, broblasts, and various other cells, as well as the biological molecules such as cytokines and chemokines they secreted [50]. They cooperated with each other to form chronic in ammatory, immunosuppressive, and tumour promotion environment so that tumour cells can escape from immune surveillance and survive against attack of effector immune cells [51].…”

Section: Discussionmentioning

confidence: 99%

Autophagy regulation patterns characterization identifies immune phenotypes and immunotherapy response in head and neck squamous cell carcinoma (HNSCC)

Zheng

et al. 2020

Preprint

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BackgroundAutophagy degraded and recycled cytoplasmic components to maintain cellular homeostasis under stress conditions, which was recognized as double-edged sword in oncogenesis and novel target in cancer treatment. However, comprehensive analysis of the relationship between autophagy regulation and immunity has not been reported yet. MethodsUnsupervised consensus clustering algorithm was used to identify autophagy regulation patterns. LASSO cox regression algorithm was used to build a scoring system (ATGscore) to represent the individual autophagy regulation pattern. Then integrated analysis of autophagy regulation patterns and ATGscore was performed.ResultsWe have successful depicted five autophagy regulation patterns and established a scoring system (ATGscore) to represent it, which was shown to be significantly correlated with TIME infiltration, immune phenotypes, molecular subtypes, and genetic variation, etc. in 1165 head and neck squamous cell carcinoma (HNSCC) patients. Moreover, ATGscore was an independent prognostic factor and potent predictor for clinical response to immune-checkpoint inhibitors (ICIs) targeting immunotherapy. ConclusionUnderstanding the molecular characteristics of autophagy regulation patterns in HNSCC could help us to depict the underlying mechanism of tumour immunity and lay a solid foundation on combination of autophagy targeting therapies and immunotherapies for clinical application in HNSCC.

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Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy

Cited by 822 publications

References 102 publications

Exosomal miRNAs in tumor microenvironment

Exosomal miRNAs in tumor microenvironment

Shaping the Innate Immune Response by Dietary Glucans: Any Role in the Control of Cancer?

Autophagy regulation patterns characterization identifies immune phenotypes and immunotherapy response in head and neck squamous cell carcinoma (HNSCC)

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