Immune cells recruitment and activation by Tityus serrulatus scorpion venom

Fialho, Eder Magalhães Silva; Maciel, Márcia C.G.; Silva, Arlley C.B.; Reis, Aramys Silva; Assunção, Anne Karine Martins; Fortes, Thiare S.; Silva, Lucilene A.; Guerra, Rosane Nassar Meireles; Kwasniewski, Fábio Henrique; Nascimento, Flávia R.F.

doi:10.1016/j.toxicon.2011.08.006

Cited by 41 publications

(26 citation statements)

References 35 publications

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“…Similar data were observed with C. d. terrificus venom [29]. It was also shown that Tityus serrulatus scorpion venom induced an increase in IL-10 and a decrease in IL-6 and TNF [46]. Cardoso and Sampaio et al [21,47] also reported that inhibitory effects induced by crotoxin on chemotaxis and macrophage phagocytosis may increase IL-10.…”

Section: Discussionsupporting

confidence: 80%

“…Increased cytokines levels during the acute stage have been described by several authors in accidents involving venomous animals [4,33,[40][41][42]. Studies involving scorpion venom demonstrated a positive physiopathological correlation between cytokine concentrations and severity of clinical manifestations [43][44][45][46] Systemic toxicity is markedly affected by cytokines release. Increase IL-10 levels in peritoneal fluid at 12 hour and at 3h and 12h in macerated lungs may play an important role in immune response modulation, favoring a shift from a Th1 towards a Th2 cytokine.…”

Section: Discussionmentioning

confidence: 98%

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Evaluation of systemic inflammatory response and lung injury induced by Crotalus durissus cascavella venom

Azevêdo

Figueiredo

Pinto³

et al. 2020

PLoS ONE

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This study investigated the systemic inflammatory response and mechanism of pulmonary lesions induced by Crotalus durissus cascavella venom in murine in the state of Bahia. In order to investigate T helper Th1, Th2 and Th17 lymphocyte profiles, we measured interleukin (IL) -2, IL-4, IL-6, IL-10, IL-17, tumor necrosis factor (TNF) and interferon gamma (IFN-γ) levels in the peritoneal fluid and macerated lungs of mice and histopathological alterations at the specific time windows of 1h, 3h, 6h, 12h, 24h and 48h after inoculation with Crotalus durissus cascavella venom. The data demonstrated an increase of acute-phase cytokines (IL-6 and TNF) in the first hours after inoculation, with a subsequent increase in IL-10 and IL-4, suggesting immune response modulation for the Th2 profile. The histopathological analysis showed significant morphological alterations, compatible with acute pulmonary lesions, with polymorphonuclear leukocyte (PMN) infiltration, intra-alveolar edema, congestion, hemorrhage and atelectasis. These findings advance our understanding of the dynamics of envenomation and contribute to improve clinical management and antiophidic therapy for individuals exposed to venom.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 98%

Evaluation of systemic inflammatory response and lung injury induced by Crotalus durissus cascavella venom

Azevêdo

Figueiredo

Pinto³

et al. 2020

PLoS ONE

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“…Studies performed with the T. serrulatus venom and/or its major toxins, showed an inmunomodulatory activity in macrophages. High levels of tumor necrosis factor (TNF)-a, interleukin (IL)-1b, IL-6, IL-8 and IL-10 were observed in supernatants of macrophages from mice exposed to T. serrulatus venom and its major toxins (Fialho et al, 2011;Petricevich et al, 2007). In the same way, increased levels of IL-1a, IL-1b, IL-6 and IL-10 were observed in sera from mice exposed to Centruroides noxius scorpion venom (Petricevich, 2006).…”

Section: Immuno-modulatorsmentioning

confidence: 99%

Scorpion venom components as potential candidates for drug development

Ortíz

Gurrola

Schwartz

et al. 2015

Toxicon

269

218

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Scorpions are well known for their dangerous stings that can result in severe consequences for human beings, including death. Neurotoxins present in their venoms are responsible for their toxicity. Due to their medical relevance, toxins have been the driving force in the scorpion natural compounds research field. On the other hand, for thousands of years, scorpions and their venoms have been applied in traditional medicine, mainly in Asia and Africa. With the remarkable growth in the number of characterized scorpion venom components, several drug candidates have been found with the potential to tackle many of the emerging global medical threats. Scorpions have become a valuable source of biologically active molecules, from novel antibiotics to potential anticancer therapeutics. Other venom components have drawn attention as useful scaffolds for the development of drugs. This review summarizes the most promising candidates for drug development that have been isolated from scorpion venoms.

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“…Although the production of pro- and anti-inflammatory cytokines in response to tissue injury is essential to repair tissue structure and function, excessive generation of proinflammatory cytokines can aggravate tissue damage [3]. Many different cytokines are released following severe envenomation.…”

Section: Introductionmentioning

confidence: 99%

Neutralizing Effects ofMimosa tenuifloraExtracts against Inflammation Caused byTityus serrulatusScorpion Venom

Bitencourt

Lima

Torres-Rêgo

et al. 2014

BioMed Research International

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Scorpion bite represents a significant and serious public health problem in certain regions of Brazil, as well as in other parts of the world. Inflammatory mediators are thought to be involved in the systemic and local immune response induced by Tityus serrulatus scorpion envenomation. The aim of this study was to evaluate the effect of extracts of Mimosa tenuiflora on model envenomation. In mice, the envenomation model is induced by Tityus serrulatus venom. Previous treatment of mice with fractions from M. tenuiflora was able to suppress the cell migration to the peritoneal cavity. The treatment of mice with M. tenuiflora extracts also decreased the levels of IL-6, IL-12, and IL-1β. We concluded that the administration of the extract and fractions resulted in a reduction in cell migration and showed a reduction in the level of proinflammatory cytokines. This study demonstrates, for the first time, the anti-inflammatory effect of aqueous extract from the Mimosa tenuiflora plant on T. serrulatus venom.

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Immune cells recruitment and activation by Tityus serrulatus scorpion venom

Cited by 41 publications

References 35 publications

Evaluation of systemic inflammatory response and lung injury induced by Crotalus durissus cascavella venom

Evaluation of systemic inflammatory response and lung injury induced by Crotalus durissus cascavella venom

Scorpion venom components as potential candidates for drug development

Neutralizing Effects ofMimosa tenuifloraExtracts against Inflammation Caused byTityus serrulatusScorpion Venom

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