Immune Cells Functioning Features in Individuals With Aggressive - And Depressive-Like Behaviors

Маркова, Е. В.; Knyazheva, M.; Rumina, Tatiana Vladimirovna; Козлов, В. А.

doi:10.12731/wsd-2014-8-10

Cited by 4 publications

(2 citation statements)

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“…Учитывая наличие в популяции половозрелых самцов (CBA×C57BL/6)F1 особей с активным и пассивным типами поведения, со свойственными им определенными структурными и функциональными характеристиками нервной и иммунной систем и различными психофизиологическими реакциями на стрессовые воздействия [5, 19,20], для формирования однородных экспериментальных групп всем мышам был предварительно проведен тест Открытое поле. В эксперимент были включены только животные с активным типом поведения, которое формировалось в результате многократного опыта побед в ежедневных межсамцовых конфронтациях с подчиненным партнером (модель хронического социального конфликта) [21].…”

Section: материалы и методыunclassified

Коррекция паттернов агрессивного поведения модулированными ex vivo иммунокомпетентными клетками: экспериментальное исследование

Маркова¹,

Серенко²

2022

СВПН

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Background. Aggression and aggressive behavior is a serious medical and biological problem, including those associated with a high prevalence among psychiatric patients and the lack of selective corrective means. The study of the pathogenetic mechanisms of aggression and the search for approaches to therapy within the framework of neuroimmune interaction is currently an extremely promising direction. The significant role of immunocompetent cells and their biologically active products in the pathogenesis of aggression, the unidirectional effect of most psychoactive substances on the cells of the central nervous system and the immune system allow us to consider immunocompetent cells as model objects for influencing the intersystem functional relationship in order to correct aggressive behavior. Objective: to study the effect of immunocompetent cells modulated ex vivo by a psychoactive substance on the behavior patterns of aggressive animals. Materials and Methods. The study was performed on 4-month-old male mice (CBAxC57BL/6)F1. Results and Discussion. It has been shown that in vitro treatment of splenocytes of aggressive mice with aminazine changes the functional activity of cells, which is expressed in a decrease in proliferative activity and production of cytokines IL-2, IL-6, and IFN-γ. Transplantation of immunocompetent cells of aggressive donors modulated ex vivo with aminazine achieves editing of aggressive behavior patterns in syngeneic aggressive recipients, as evidenced by a decrease in aggressive motivation, the level of aggressiveness, anxiety, and locomotor activity. The presented results show the promise of using cellular technologies to correct aggressive behavior.

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Section: материалы и методыunclassified

Коррекция паттернов агрессивного поведения модулированными ex vivo иммунокомпетентными клетками: экспериментальное исследование

Маркова¹,

Серенко²

2022

СВПН

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“…Ранее нами и другими исследователями установлено, что иммунные клетки животных с активным и пассивным типами поведения различаются по функциональной активности. Так, показано, что спленоциты мышей (CBA x C57BL/6)F1 с оппозитными типами поведения различны по фенотипическим характеристикам, спонтанной и митоген-индуцированной пролиферативной активности, уровню синтеза и продукции основных регуляторных цитокинов и ýкспрессии их генов [14][15][16][17]. Также продемонстрирована возможность направленного изменения параметров функциональной активности иммунной и нервной систем организма у половозрелых животных трансплантацией иммунных клеток с определенными функциональными характеристиками [18][19][20].…”

Section: Introductionunclassified

Proliferation and apoptosis of experimental animal’s lymphocytes after multiple transplantation of immune cells from opposite behavioral types of donors carried out in the juvenile period

et al. 2019

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The aim of the study was to determine subpopulation content, proliferative activity and T-lymphocyte apoptosis level in adult mice-recipients that in the juvenile period underwent multiple transplantation of immune cells with different functional properties from opposite behavioral types of donors. Materials and methods. The study was carried out on male mice (CBAxC57BL/6) F1 (n = 190), which underwent transplantation of immune cells with definite functional properties three times starting from the age of 4–5-weeks. Phenotyping of recipients’ spleen cells was carried out by flow cytometry with monoclonal antibodies against CD3+, СD4+, CD8+. Splenocyte proliferation and apoptosis were estimated. Results. Animals that underwent threefold transplantation of immune cells from singeing opposite behavioral types of donors in the juvenile period revealed different functional properties of spleen lymphocytes in adults. The most pronounced changes were detected in the animals receiving the immune cells from donors with passive behavior type. The lymphocytes of these recipients were characterized by relatively low proliferative activity and T-mytogen sensitivity, decreased CD4+, CD8+ apoptosis level under deficient medium conditions and increased level of activation and dexamethasone-induced apoptosis in CD4+ lymphocytes.

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Cytokine Production by Splenic Cells in C57BL/6J Mice with Depression-Like Behavior Depends on the Duration of Social Stress

et al. 2018

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We studied the influence of depression-like behavior developed in C57BL/6J mice under conditions of social stress of different duration on cytokine production by splenic cells. Imbalance of the pro- and anti-inflammatory cytokines was detected at the early stage of depression-like behavior (10-day experience of defeats): increased production of proinflammatory IL-2 and IL-6 cytokines along with a decrease in anti-inflammatory IL-10 level; the levels of IL-1β, TNFα, IFNγ, and IL-4 remained unaffected. At later terms (20 days of confrontations), we revealed more pronounced changes in spontaneous production of proinflammatory cytokines that were not detected after shorter social stress. These findings suggest that cytokine profile depends on duration of social stress. Possible mechanisms of cytokine production during formation of depression-like state are discussed.

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Immune Cells Functioning Features in Individuals With Aggressive - And Depressive-Like Behaviors

Cited by 4 publications

References 0 publications

Коррекция паттернов агрессивного поведения модулированными ex vivo иммунокомпетентными клетками: экспериментальное исследование

Коррекция паттернов агрессивного поведения модулированными ex vivo иммунокомпетентными клетками: экспериментальное исследование

Proliferation and apoptosis of experimental animal’s lymphocytes after multiple transplantation of immune cells from opposite behavioral types of donors carried out in the juvenile period

Cytokine Production by Splenic Cells in C57BL/6J Mice with Depression-Like Behavior Depends on the Duration of Social Stress

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