Immune cell targeting nanoparticles: a review

Lee, Na Kyeong; Kim, Se-Na; Park, Chun Gwon

doi:10.1186/s40824-021-00246-2

Cited by 38 publications

(18 citation statements)

References 72 publications

(68 reference statements)

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“…These groundbreaking advances were recognized by the 2018 Nobel Prize in Physiology or Medicine that was awarded to James Allison and Tasuku Honjo for “the discovery of cancer therapy by inhibition of negative immune regulation” [ 245 , 246 ]. In particular, the Nobel prize was awarded for the identification of immune checkpoints including cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and programmed cell death-1/programmed death-ligand 1 (PD-1/PD-L1), leading the research boom for anticancer therapy by targeting these checkpoints [ 247 ]. In addition, nanomedicines prove to trigger the induction of immunogenic cell death (ICD), which is a specific mode of cell death with tumor antigens and danger-associated molecular patterns released to boost anticancer immunity [ 248 , 249 ].…”

Section: Hollow Nanoplatforms For Nir-ii Ptt-based Multi-modal Therapiesmentioning

confidence: 99%

Recent advances in near-infrared-II hollow nanoplatforms for photothermal-based cancer treatment

et al. 2022

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Near-infrared-II (NIR-II, 1000–1700 nm) light-triggered photothermal therapy (PTT) has been regarded as a promising candidate for cancer treatment, but PTT alone often fails to achieve satisfactory curative outcomes. Hollow nanoplatforms prove to be attractive in the biomedical field owing to the merits including good biocompatibility, intrinsic physical-chemical nature and unique hollow structures, etc. On one hand, hollow nanoplatforms themselves can be NIR-II photothermal agents (PTAs), the cavities of which are able to carry diverse therapeutic units to realize multi-modal therapies. On the other hand, NIR-II PTAs are capable of decorating on the surface to combine with the functions of components encapsulated inside the hollow nanoplatforms for synergistic cancer treatment. Notably, PTAs generally can serve as good photoacoustic imaging (PAI) contrast agents (CAs), which means such kind of hollow nanoplatforms are also expected to be multifunctional all-in-one nanotheranostics. In this review, the recent advances of NIR-II hollow nanoplatforms for single-modal PTT, dual-modal PTT/photodynamic therapy (PDT), PTT/chemotherapy, PTT/catalytic therapy and PTT/gas therapy as well as multi-modal PTT/chemodynamic therapy (CDT)/chemotherapy, PTT/chemo/gene therapy and PTT/PDT/CDT/starvation therapy (ST)/immunotherapy are summarized for the first time. Before these, the typical synthetic strategies for hollow structures are presented, and lastly, potential challenges and perspectives related to these novel paradigms for future research and clinical translation are discussed. Graphical Abstract

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Section: Hollow Nanoplatforms For Nir-ii Ptt-based Multi-modal Therapiesmentioning

confidence: 99%

Recent advances in near-infrared-II hollow nanoplatforms for photothermal-based cancer treatment

et al. 2022

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“…However, systemic administration provides liver, kidney, and spleen accumulation that compromise a preferential uptake by tumour-infiltrated MDSCs/TAMs. To avoid this important limitation, several studies have developed NP-based targeting systems employing surface markers to specifically target defined immune cell subsets [ 222 ]. For instance, polyethylene glycol (PEG)-sheddable, mannose-modified NPs were developed to target M2-like TAMs via mannose-CD206 binding after pH-sensitive PEG dissociation in the acidic TME [ 223 ].…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Targeting tumour-reprogrammed myeloid cells: the new battleground in cancer immunotherapy

et al. 2022

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Tumour microenvironment is a complex ecosystem in which myeloid cells are the most abundant immune elements. This cell compartment is composed by different cell types, including neutrophils, macrophages, dendritic cells, and monocytes but also unexpected cell populations with immunosuppressive and pro-tumour roles. Indeed, the release of tumour-derived factors influences physiological haematopoiesis producing unconventional cells with immunosuppressive and tolerogenic functions such as myeloid-derived suppressor cells. These pro-tumour myeloid cell populations not only support immune escape directly but also assist tumour invasion trough non-immunological activities. It is therefore not surprising that these cell subsets considerably impact in tumour progression and cancer therapy resistance, including immunotherapy, and are being investigated as potential targets for developing a new era of cancer therapy. In this review, we discuss emerging strategies able to modulate the functional activity of these tumour-supporting myeloid cells subverting their accumulation, recruitment, survival, and functions. These innovative approaches will help develop innovative, or improve existing, cancer treatments.

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“…The released DOX and PT activities of GO/MnWO4/PEG significantly ablated mouse tumors in vivo, suggesting the versatility of GO/MnWO4/PE for multimodal imaging-guided cancer synergistic therapy. On the other hand, AuNPs have tunable and enhanced adsorption cross-sections, making them preferred versatile imaging probes for MRI, CT, PA, and FL imaging [ 91 , 92 , 93 , 94 ]. However, a reduction in the cross-section of AuNPs hinders the acceptable level of PA signal amplitudes under the visible light range.…”

Section: Graphene-based Photoacoustic Imagingmentioning

confidence: 99%

State of the Art in Carbon Nanomaterials for Photoacoustic Imaging

et al. 2022

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Photoacoustic imaging using energy conversion from light to ultrasound waves has been developed as a powerful tool to investigate in vivo phenomena due to their complex characteristics. In photoacoustic imaging, endogenous chromophores such as oxygenated hemoglobin, deoxygenated hemoglobin, melanin, and lipid provide useful biomedical information at the molecular level. However, these intrinsic absorbers show strong absorbance only in visible or infrared optical windows and have limited light transmission, making them difficult to apply for clinical translation. Therefore, the development of novel exogenous contrast agents capable of increasing imaging depth while ensuring strong light absorption is required. We report here the application of carbon nanomaterials that exhibit unique physical, mechanical, and electrochemical properties as imaging probes in photoacoustic imaging. Classified into specific structures, carbon nanomaterials are synthesized with different substances according to the imaging purposes to modulate the absorption spectra and highly enhance photoacoustic signals. In addition, functional drugs can be loaded into the carbon nanomaterials composite, and effective in vivo monitoring and photothermal therapy can be performed with cell-specific targeting. Diverse applied cases suggest the high potential of carbon nanomaterial-based photoacoustic imaging in in vivo monitoring for clinical research.

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Immune cell targeting nanoparticles: a review

Cited by 38 publications

References 72 publications

Recent advances in near-infrared-II hollow nanoplatforms for photothermal-based cancer treatment

Recent advances in near-infrared-II hollow nanoplatforms for photothermal-based cancer treatment

Targeting tumour-reprogrammed myeloid cells: the new battleground in cancer immunotherapy

State of the Art in Carbon Nanomaterials for Photoacoustic Imaging

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