Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis

Zhu, Lingling; Yu, Xianzhe; Cao, Ting; Deng, Han‐Yu; Tang, Xiaojun; Lin, Qing; Zhou, Qinghua

doi:10.1016/j.apsb.2023.03.004

Cited by 16 publications

(10 citation statements)

References 137 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Platelets adhere to CTCs, providing a protective layer that shields them from both mechanical forces and NK cell–mediated immune responses. NK cells have an influence on cancer metastasis by employing diverse methods and engaging with CTCs via distinct ligands and receptors ( Figure 12D ) ( 182 ).…”

Section: Cell Membrane Biomimetic Nanoparticles For Ctcsmentioning

confidence: 99%

“…For instance, regulatory T cells (Tregs) have the ability to shield tumor cells from being recognized by the immune system, enabling their survival, growth, and acquisition of characteristics that facilitate the spread of cancer to other parts of the body. Tregs demonstrate immunosuppressive capabilities ( 182 ). Therefore, utilizing T-cell biomimetic delivery platforms that display tumor-specific T-cell receptors can serve as extremely precise medication carriers that target metastasis.…”

Section: Cell Membrane Biomimetic Nanoparticles For Ctcsmentioning

confidence: 99%

See 1 more Smart Citation

Research progress of cell membrane biomimetic nanoparticles for circulating tumor cells

Zhang,

Wang

2024

Front. Oncol.

View full text Add to dashboard Cite

Early detection of cancer is crucial to reducing fatalities and improving patient outcomes. Metastasis is the first stage of aggressive cancers, often occurring before primary lesions can be seen. It occurs when cancerous cells disseminate to distant, non-malignant organs through the bloodstream, known as circulating tumor cells (CTCs). CTCs, or cancer tumor cells, are valuable indicators for predicting treatment response, metastasis progression, and disease progression. However, they are primarily used for research due to challenges like heterogeneity, separation from blood, and lack of clinical validation. Only a few methods have been approved for clinical use. One area of research is the isolation and identification of CTCs, which could significantly impact early cancer detection and prognosis. Current technologies using whole-blood samples use size, immunoaffinity, and density approaches, along with positive and negative enrichment techniques. Surface modification of nanomaterials is important for effective cancer therapies because it improves their ability to target and reduces interactions with healthy tissues. Consequently, researchers have created biomimetic nanoparticles covered with cell membranes using functional, targeted, and biocompatible coating technology. Nanoparticles with membranes can target specific cells, stay in circulation for longer, and avoid immune responses, which makes them much better at capturing CTCs. This study examines the current opportunities and difficulties associated with using cell membrane–coated nanoparticles as a capture technique for CTCs. In addition, we examine potential future developments in light of the current obstacles and investigate areas that require further research to fully understand its growing clinical possibilities.

show abstract

Section: Cell Membrane Biomimetic Nanoparticles For Ctcsmentioning

confidence: 99%

Section: Cell Membrane Biomimetic Nanoparticles For Ctcsmentioning

confidence: 99%

Research progress of cell membrane biomimetic nanoparticles for circulating tumor cells

Zhang,

Wang

2024

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…Immune cell membrane-based biomimetic nano-carriers have an increasing therapeutic efficacy against cancer metastasis through immune evasion, prolonged circulation, high tumor bioaccumulation and immunosuppression of the TME [138]. It is known that neutrophils can be used as carriers for cancer nanotherapeutics such as liposomes, magnetite NPs, and PEGylated poly (lactic-co-glycolic acid) (PLGA) [139], so that neutrophil membrane-coated NPs are able to keep the antigenic exterior and associated membrane functions of the host cells, making them ideal decoys for neutrophil-targeted biological molecules [140].…”

Section: Anti-invasion and Anti-metastatic Nanomaterialsmentioning

confidence: 99%

A Nanorobotics-Based Approach of Breast Cancer in the Nanotechnology Era

Neagu,

Jayaweera,

Weraduwage

et al. 2024

IJMS

View full text Add to dashboard Cite

We are living in an era of advanced nanoscience and nanotechnology. Numerous nanomaterials, culminating in nanorobots, have demonstrated ingenious applications in biomedicine, including breast cancer (BC) nano-theranostics. To solve the complicated problem of BC heterogeneity, non-targeted drug distribution, invasive diagnostics or surgery, resistance to classic onco-therapies and real-time monitoring of tumors, nanorobots are designed to perform multiple tasks at a small scale, even at the organelles or molecular level. Over the last few years, most nanorobots have been bioengineered as biomimetic and biocompatible nano(bio)structures, resembling different organisms and cells, such as urchin, spider, octopus, fish, spermatozoon, flagellar bacterium or helicoidal cyanobacterium. In this review, readers will be able to deepen their knowledge of the structure, behavior and role of several types of nanorobots, among other nanomaterials, in BC theranostics. We summarized here the characteristics of many functionalized nanodevices designed to counteract the main neoplastic hallmark features of BC, from sustaining proliferation and evading anti-growth signaling and resisting programmed cell death to inducing angiogenesis, activating invasion and metastasis, preventing genomic instability, avoiding immune destruction and deregulating autophagy. Most of these nanorobots function as targeted and self-propelled smart nano-carriers or nano-drug delivery systems (nano-DDSs), enhancing the efficiency and safety of chemo-, radio- or photodynamic therapy, or the current imagistic techniques used in BC diagnosis. Most of these nanorobots have been tested in vitro, using various BC cell lines, as well as in vivo, mainly based on mice models. We are still waiting for nanorobots that are low-cost, as well as for a wider transition of these favorable effects from laboratory to clinical practice.

show abstract

“…Among the antigen-presenting cells in the immune system, dendritic cells (DCs) are particularly significant as they capture antigens and activate T cells, thus initiating immune responses [ 40 ]. Targeting DCs can direct specific immune reactions.…”

Section: Immunomodulatory Strategies In Drug Deliverymentioning

confidence: 99%

Nanomaterial-Driven Precision Immunomodulation: A New Paradigm in Therapeutic Interventions

Aljabali,

Obeid,

Gammoh

et al. 2024

Cancers

View full text Add to dashboard Cite

Immunotherapy is a rapidly advancing field of research in the treatment of conditions such as cancer and autoimmunity. Nanomaterials can be designed for immune system manipulation, with precise targeted delivery and improved immunomodulatory efficacy. Here, we elaborate on various strategies using nanomaterials, including liposomes, polymers, and inorganic NPs, and discuss their detailed design intricacies, mechanisms, and applications, including the current regulatory issues. This type of nanomaterial design for targeting specific immune cells or tissues and controlling release kinetics could push current technological frontiers and provide new and innovative solutions for immune-related disorders and diseases without off-target effects. These materials enable targeted interactions with immune cells, thereby enhancing the effectiveness of checkpoint inhibitors, cancer vaccines, and adoptive cell therapies. Moreover, they allow for fine-tuning of immune responses while minimizing side effects. At the intersection of nanotechnology and immunology, nanomaterial-based platforms have immense potential to revolutionize patient-centered immunotherapy and reshape disease management. By prioritizing safety, customization, and compliance with regulatory standards, these systems can make significant contributions to precision medicine, thereby significantly impacting the healthcare landscape.

show abstract

Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis

Cited by 16 publications

References 137 publications

Research progress of cell membrane biomimetic nanoparticles for circulating tumor cells

Research progress of cell membrane biomimetic nanoparticles for circulating tumor cells

A Nanorobotics-Based Approach of Breast Cancer in the Nanotechnology Era

Nanomaterial-Driven Precision Immunomodulation: A New Paradigm in Therapeutic Interventions

Contact Info

Product

Resources

About