Immune Cell‐Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery

Xie, Zhiwei; Su, Yixue; Kim, Gloria B.; Selvi, Erhan; Ma, Chuying; Aragon‐Sanabria, Virginia; Hsieh, Jer Tsong; Dong, Chuan; Yang, Jian

doi:10.1002/smll.201603121

Cited by 76 publications

(56 citation statements)

References 48 publications

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“…By taking advantage of the innate immune system cells’ tumor targeting ability, anti-tumor drug loaded NPs were internalized within macrophages and delivered to tumor cells via cell-cell binding, causing tumor cell death [78]. Exosomes of APCs are enriched in co-stimulatory molecules and the major histocompatibility complex (MHC).…”

Section: Therapeutic Immune Modulation By Engineered Nanoparticlesmentioning

confidence: 99%

Effects of engineered nanoparticles on the innate immune system

Liu

Hardie

Zhang

et al. 2017

Seminars in Immunology

219

131

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Engineered nanoparticles (NPs) have broad applications in industry and nanomedicine. When NPs enter the body, interactions with the immune system are unavoidable. The innate immune system, a non-specific first line of defense against potential threats to the host, immediately interacts with introduced NPs and generates complicated immune responses. Depending on their physicochemical properties, NPs can interact with cells and proteins to stimulate or suppress the innate immune response, and similarly activate or avoid the complement system. NPs size, shape, hydrophobicity and surface modification are the main factors that influence the interactions between NPs and the innate immune system. In this review, we will focus on recent reports about the relationship between the physicochemical properties of NPs and their innate immune response, and their applications in immunotherapy.

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Section: Therapeutic Immune Modulation By Engineered Nanoparticlesmentioning

confidence: 99%

Effects of engineered nanoparticles on the innate immune system

Liu

Hardie

Zhang

et al. 2017

Seminars in Immunology

219

131

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“…By taking advantage of innate immune cells’ ability to target tumor cells, Yang’s lab developed a novel drug delivery system employing macrophages to carry and navigate BPLP-PLLA nanoparticles to achieve cancer specific drug delivery. [51] Specifically, BPLP-PLLA nanoparticles encapsulated with an anti-BRAF V600E mutant melanoma specific drug (PLX4032) were first loaded to macrophage model cells, THP-1, through cell uptake. To improve the cell uptake efficiency of nanoparticles, the drug encapsulated BPLP-PLLA nanoparticles were modified with muramyl tripeptide (MTP).…”

Section: Citrate-based Biodegradable Photoluminescent Polymers (Bplps)mentioning

confidence: 99%

“…[49–51] For example, NIR-imaging information encryption and in vivo NIR fluorescence imaging of the stomach of a living mouse were achieved using citrate-based CDs synthesized from CA and urea. [52] Using the biodegradable photoluminescent polylactones (BPLPLs), an immune cell-mediated nanoparticle targeting drug delivery system was created and demonstrated significant theranostic effects.…”

Section: Introductionmentioning

confidence: 99%

“…[52] Using the biodegradable photoluminescent polylactones (BPLPLs), an immune cell-mediated nanoparticle targeting drug delivery system was created and demonstrated significant theranostic effects. [51] Moreover, molecular fluorophore synthesized from CA and Cysteine (CA-Cys) was applied as selective chloride sensors, and a smartphone operated chloridometer was further designed for the diagnosis of cystic fibrosis (CF). [48, 53] Overall, the development of citrate-based fluorescent materials in current studies has played a significant role in theranostic healthcare and regenerative engineering.…”

Section: Introductionmentioning

confidence: 99%

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Citrate‐Based Fluorescent Biomaterials

Shan

Hsieh

Bai

et al. 2018

Adv Healthcare Materials

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Fluorescence imaging has emerged as a promising technique for monitoring and assessing various biologically relevant species in cells and organisms, driving the demand for effective fluorescent agents with good biocompatibility and high fluorescence performance. However, traditional fluorescent agents, such as quantum dots (QDs) and organic dyes, either suffer from toxicity concerns or poor fluorescence performance (e.g., low photobleaching-resistance). In this regard, citrate-based fluorescent biomaterials, which are synthesized from the natural and biocompatible precursor of citric acid (CA), have become competitive alternatives for fluorescence imaging owing to their biocompatibility, cost effectiveness, straightforward synthetic routes, flexible designability, as well as strong fluorescence with adjustable excitation/emission wavelengths. Accordingly, numerous citrate-based biomaterials, including carbon dots (CDs), biodegradable photoluminescent polymers (BPLPs), and small molecular fluorophores, have been developed and researched in the past few decades. This review discusses recent progress in the research and development of citrate-based fluorescent materials with emphasis on their design and synthesis considerations, material properties, fluorescence properties and mechanisms, as well as biomedical applications. It is expected that this review will provide an insightful discussion on the citrate-based fluorescent biomaterials, and lead to innovations for the next generation of fluorescent biomaterials and fluorescence-based biomedical technology.

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“…Some metals, such as gold (Au) and Gadolinium (Gd), can have antitumor activity besides being an imaging tracer (88). Gd-based NPs (AGuIX) were successfully used as both MRI contrast agent and therapy in experimental animal models of melanoma metastases (115)(116)(117)(118)(119)(120). Another novel theranostic nanostructure for melanoma was a NP biodegradable photoluminescent polymer-poly (lactic acid) (BPLP-PLA) loaded with anti-BRAF V600E-specific drug (PLX4032) and muramyl peptide.…”

Section: Theranostic Nanomedicine and Melanoma Therapymentioning

confidence: 99%

Nanomedicine in Melanoma: Current Trends and Future Perspectives

El-Kenawy

Constantin

Hassan

et al. 2017

Cutaneous Melanoma: Etiology and Therapy

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Abstract:As cutaneous melanoma is a highly aggressive and drug-resistant cancer, there is intense research focusing on developing new, efficient drugs. Nanomedicine focuses on developing different groups of nanomaterials for both diagnosis and therapy, and this combination of specific diagnosis and therapy is called theranostics. Nanomaterials tailored as delivery vehicles can be nanocapsules, nanorods, nanotubes, nanoshells, and nanocages. All these structures protect the intended drug against degradation and enhance its stability. The development and characterization of polymeric nanoparticles, polymeric micelles, liposomes, nanohydrogel, dendrimers, inorganic nanoparticles, and hybrid nanocarriers are among the delivery vehicles that transport different anticancer agents. Functionalization of nanocarriers with specific molecules, such as antibodies, can generate different smart nanodrugs for application in cancer therapy and/or diagnosis. Nanotherapeutic strategies deal with several shortcomings that comprise of tumor characteristics, biological barriers, biocompatibility, and so on. As nanostructures interact with various host biomolecules, comprehensive in vitro cellular models call for evaluation of physicochemical properties, dose, and time of action of nanomaterials, while in vivo assessments would provide valuable data regarding the level of absorption, tissue/organ distribution, and metabolism. The future perspectives in nanotechnology applied to cancer overcomes the translational barrier from the laboratory to the clinical application to potentially improve conventional theranostic techniques.

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Immune Cell‐Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery

Cited by 76 publications

References 48 publications

Effects of engineered nanoparticles on the innate immune system

Effects of engineered nanoparticles on the innate immune system

Citrate‐Based Fluorescent Biomaterials

Nanomedicine in Melanoma: Current Trends and Future Perspectives

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