Immune cell infiltration in Ectomesenchymal chondromyxoid tumor: An immunohistochemical study

Almeida, Luciana Yamamoto; Dominguete, Matheus Henrique Lopes; Dominguete, Paulo Roberto; Ribeiro‐Silva, Alfredo; Teixeira, Lucas Ribeiro; León, Jorge Esquiche

doi:10.1016/j.oraloncology.2018.04.012

Cited by 6 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, as in previous studies, the present tumor was positive for S100 and GFAP, 4,6,7,12,15,19,23,26,27 demonstrating an origin from the neural crest, as well as for CD10, 28 NSE 20,29 and cyclin D1. 4,17,28 Regarding this last protein, strong nuclear ex-pression was detected, but no translocation of CCND1/IGH or amplification of the CCND1 gene was found. 28 No CD56 staining was observed, which is in agreement with a previous study 21 that reported a variable expression of this marker in its cases.…”

Section: Discussionsupporting

confidence: 87%

“…1,2,5,6,8,11,12,18,19 Histologically, the present case meets the morphological criteria for the diagnosis of ECT. 2,[4][5][6]8,11,15,[17][18][19][20][21][22][23] The tumor is characterized by a lobular growth pattern with cystic spaces and stroma with myxoid, chondroid and myxochondroid areas, and by hypercellularity -especially small cells, which seem to predominate in ECT. 5 Another particular feature is neoplastic cells surrounding muscle cells, 5,15,16,24 but this does not seem to represent evidence of an ECT's aggressive behavior.…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, a low proliferative index of this tumor has been reported in the literature. [2][3][4]14,19,26,30 Considering the variable immunohistochemical profile of the ECT, the high proliferative index suggests the need for constant monitoring of these cases, with special attention to areas containing populations of small cells.…”

Section: Discussionmentioning

confidence: 99%

“…1 Approximately 75 cases of ECT were published in English in the literature. [2][3][4] The tumor manifests as a submucosal nodule on the back of the tongue or, less frequently, at the base of the tongue and palate. 2,5 The ECT is usually small, ranging from 4 to 50 mm, 2 has no gender predilection, and affects patients between the first and eighth decades of life.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ectomesenchymal chondromyxoid tumor with a significant proliferative index: A case report

Farias¹,

Athanazio²,

Ismerim³

et al. 2019

j.rpemd

View full text Add to dashboard Cite

An ectomesenchymal chondromyxoid tumor (ECT) is a rare intraoral tumor that should be included in the differential diagnosis of other mesenchymal tumors, particularly when located in the tongue. This study reports a new case of a 34-year-old female patient with a nodular lesion on the tongue dorsum. Its clinical diagnosis was irritative fibroma. The lesion was surgically removed, and, after 2 years of follow-up, no recurrence was observed. A detailed description of the histomorphological and immunohistochemical features of the ECT was made, highlighting the high Ki-67 proliferative index observed. (Rev Port Es

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ectomesenchymal chondromyxoid tumor with a significant proliferative index: A case report

Farias¹,

Athanazio²,

Ismerim³

et al. 2019

j.rpemd

View full text Add to dashboard Cite

show abstract

“…A pontos diagnózis a klinikai jellegzetességek, a fénymikroszkópos kép és az immunhisztokémiai vizsgálatok alapján állítható fel [10]. A nemzetközi szakirodalomban eddig mindösszesen 93 esetet publikáltak [3,8,[11][12][13][14]; jelen közleményünkben -ismereteink szerint hazánkban elsőként -egy újabb esetről számolunk be.…”

unclassified

A nyelv ritka, benignus, ectomesenchymalis chondromyxoid tumora

2019

View full text Add to dashboard Cite

Ectomesenchymal chondromyxoid tumor is a rare benign intraoral soft tissue neoplasm. Till date, 93 cases have been reported in literature. Clinically, it presents as a slowly growing, painless, ﬁrm, submucosal swelling mainly occurring on the anterior two thirds of the dorsum of the tongue. Histopathologically, the tumor is characterized by a well circumscribed, lobular proliferation of round, polygonal, or fusiform cells in a net-like pattern in a myxoid to chondromyxoid background. Although it shows a morphological resemblance to myoepitheliomas of soft tissue and skin, the exact histogenesis remains unclear; a recent publication of a large series has demonstrated recurrent RREB1-MKL2 gene fusions in 90% of the cases, suggesting the possibility of a new entity. The diagnosis is largely supported by immunhistochemical investigations. Here, we present a new case of ECT occurring in a 62-year-old male who presented with a leading complaint of slowly growing painless mass arising from the anterior part of the tongue measuring about 3 cm. This lesion was diagnosed 4 years before recent admittance, but the patient did not undergo the scheduled surgical intervention and was lost to follow-up. As the tumor was still persisting and moderately enlarging, he came back to our clinic. Finally, the mass was completely resected; after 24 month of follow-up, he is doing well, with no signs of recurrence. Orv Hetil. 2019; 160(33): 1319–1323.

show abstract