Immune-Cell-Derived Exosomes for Cancer Therapy

Zhao, Yongmei; Liu, Tianqing; Zhou, Mengjiao

doi:10.1021/acs.molpharmaceut.2c00407

Cited by 24 publications

(10 citation statements)

References 161 publications

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“…reported that B lymphocytes secrete antigen-presenting vesicles ( 36 ). Since then, more and more studies have found that exosomes secreted by immune cells interact with cells in the immune system to regulate immune responses ( 37 ). Therefore, these membranous vesicles are being explored as potential immunotherapeutic reagents.…”

Section: Immune Cell-derived Exosomes and Diabetesmentioning

confidence: 99%

The Immunomodulatory effect of exosomes in diabetes: a novel and attractive therapeutic tool in diabetes therapy

Li,

Hu,

et al. 2024

Front. Immunol.

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Exosomes carry proteins, metabolites, nucleic acids and lipids from their parent cell of origin. They are derived from cells through exocytosis, are ingested by target cells, and can transfer biological signals between local or distant cells. Therefore, exosomes are often modified in reaction to pathological processes, including infection, cancer, cardiovascular diseases and in response to metabolic perturbations such as obesity and diabetes, all of which involve a significant inflammatory aspect. Here, we discuss how immune cell-derived exosomes origin from neutrophils, T lymphocytes, macrophages impact on the immune reprogramming of diabetes and the associated complications. Besides, exosomes derived from stem cells and their immunomodulatory properties and anti-inflammation effect in diabetes are also reviewed. Moreover, As an important addition to previous reviews, we describes promising directions involving engineered exosomes as well as current challenges of clinical applications in diabetic therapy. Further research on exosomes will explore their potential in translational medicine and provide new avenues for the development of effective clinical diagnostics and therapeutic strategies for immunoregulation of diabetes.

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Section: Immune Cell-derived Exosomes and Diabetesmentioning

confidence: 99%

The Immunomodulatory effect of exosomes in diabetes: a novel and attractive therapeutic tool in diabetes therapy

Li,

Hu,

et al. 2024

Front. Immunol.

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“…Exosomes derived from immune cells have immunomodulatory and therapeutic properties, and are crucial for the treatment of cancer. Immune cell-derived exosomes have attracted a lot of interest as a drug delivery platform for effective anticancer therapy, due to their outstanding biocompatibility, low immunogenicity, and high loading capacity [ 40 ]. Some researchers have found that the nanovesicles cultured with primary immune cells contain immunoglobulin, which can be used for immunotherapy [ 41 ].…”

Section: Exosomes and Drug Delivery Systemsmentioning

confidence: 99%

Advances in the Study of Exosomes as Drug Delivery Systems for Bone-Related Diseases

Huang

Wang

et al. 2023

Pharmaceutics

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Bone-related diseases are major problems and heavy burdens faced by modern society. Current clinical approaches for the treatment of these pathological conditions often lead to complications and have limited therapeutic efficacy. In this context, the development of nanotherapeutic platforms, such as extracellular vesicles, can improve the relevant therapeutic effects. In particular, exosomes are nano-sized, lipid bilayer extracellular vesicles secreted by many cells in mammals. Due to their innate capacity to transport materials—including proteins, lipids, and genes—among cells, as well as their innate attraction to target cells, they are considered to be a crucial medium for cell communication and are involved in a number of biological processes. Exosomes have been used as drug delivery vehicles in recent bone tissue engineering studies, in order to regulate bone homeostasis. However, the precise workings of the exosome regulatory network in maintaining bone homeostasis and its potential for treating bone injury remain unclear. To provide a fresh perspective for the study of exosomes in drug delivery and bone-related diseases, in this paper, we review recent studies on the roles of exosomes for drug delivery in bone homeostasis and bone-related diseases, as well as the composition and characteristics of exosomes and their regulatory roles in bone homeostasis and bone-related diseases, aiming to provide new ideas for the therapeutic application of exosomes in the treatment of bone-related diseases.

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“…Depending on the origin of the exosome, different responses can be initiated in the target cell. For example, exosomes derived from immune system cells can lead to the expansion or suppression of tumor growth based on their origin ( 34 , 35 ). Due to their immunomodulatory properties, the presence of MSC-derived exosomes can lead to tumor progression ( 36 ).…”

Section: Tumor-derived Exosomes In Pancreatic Cancer Progressionmentioning

confidence: 99%

Pancreatic cancer and exosomes: role in progression, diagnosis, monitoring, and treatment

et al. 2023

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Pancreatic cancer (PC) is one of the most dangerous diseases that threaten human life, and investigating the details affecting its progression or regression is particularly important. Exosomes are one of the derivatives produced from different cells, including tumor cells and other cells such as Tregs, M2 macrophages, and MDSCs, and can help tumor growth. These exosomes perform their actions by affecting the cells in the tumor microenvironment, such as pancreatic stellate cells (PSCs) that produce extracellular matrix (ECM) components and immune cells that are responsible for killing tumor cells. It has also been shown that pancreatic cancer cell (PCC)-derived exosomes at different stages carry molecules. Checking the presence of these molecules in the blood and other body fluids can help us in the early stage diagnosis and monitoring of PC. However, immune system cell-derived exosomes (IEXs) and mesenchymal stem cell (MSC)-derived exosomes can contribute to PC treatment. Immune cells produce exosomes as part of the mechanisms involved in the immune surveillance and tumor cell-killing phenomenon. Exosomes can be modified in such a way that their antitumor properties are enhanced. One of these methods is drug loading in exosomes, which can significantly increase the effectiveness of chemotherapy drugs. In general, exosomes form a complex intercellular communication network that plays a role in developing, progressing, diagnosing, monitoring, and treating pancreatic cancer.

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Immune-Cell-Derived Exosomes for Cancer Therapy

Cited by 24 publications

References 161 publications

The Immunomodulatory effect of exosomes in diabetes: a novel and attractive therapeutic tool in diabetes therapy

The Immunomodulatory effect of exosomes in diabetes: a novel and attractive therapeutic tool in diabetes therapy

Advances in the Study of Exosomes as Drug Delivery Systems for Bone-Related Diseases

Pancreatic cancer and exosomes: role in progression, diagnosis, monitoring, and treatment

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