Immune cell–camouflaged surface-engineered nanotherapeutics for cancer management

Jain, Naitik; Shahrukh, Syed; Famta, Paras; Shah, Saurabh; Vambhurkar, Ganesh B.; Khatri, Dharmendra Kumar; Singh, Shashi Bala; Srivastava, Saurabh

doi:10.1016/j.actbio.2022.11.001

Cited by 10 publications

(3 citation statements)

References 129 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A variety of natural CMs are used to camouflage NPs, including blood CM (platelet membrane, red CM), white CM (macrophages, 73 lymphocytes, dendritic cells, spongy NE membrane), 74 , 75 cancer CM (CCM), stem CM, and adipocyte membrane. Depending on the cellular membranes wrapped around the NP surfaces, the corresponding CM-NPs have different advantages.…”

Section: Bndds Based On Natural Cmsmentioning

confidence: 99%

Biomimetic Nano-Drug Delivery System: An Emerging Platform for Promoting Tumor Treatment

Han,

Gong,

Yang

et al. 2024

IJN

View full text Add to dashboard Cite

With the development of nanotechnology, nanoparticles (NPs) have shown broad prospects as drug delivery vehicles. However, they exhibit certain limitations, including low biocompatibility, poor physiological stability, rapid clearance from the body, and nonspecific targeting, which have hampered their clinical application. Therefore, the development of novel drug delivery systems with improved biocompatibility and high target specificity remains a major challenge. In recent years, biofilm mediated biomimetic nano-drug delivery system (BNDDS) has become a research hotspot focus in the field of life sciences. This new biomimetic platform uses bio-nanotechnology to encapsulate synthetic NPswithin biomimetic membrane, organically integrating the low immunogenicity, low toxicity, high tumor targeting, good biocompatibility of the biofilm with the adjustability and versatility of the nanocarrier, and shows promising applications in the field of precision tumor therapy. In this review, we systematically summarize the new progress in BNDDS used for optimizing drug delivery, providing a theoretical reference for optimizing drug delivery and designing safe and efficient treatment strategies to improve tumor treatment outcomes.

show abstract

Section: Bndds Based On Natural Cmsmentioning

confidence: 99%

Biomimetic Nano-Drug Delivery System: An Emerging Platform for Promoting Tumor Treatment

Han,

Gong,

Yang

et al. 2024

IJN

View full text Add to dashboard Cite

show abstract

“…This process involves the use of a monomer, an initiator, and a cross-linker, which, when exposed to radiation or heat, initiates polymerization. In situ polymerization offers several advantages, including the assurance of coating integrity, simple encapsulation of the payload, and easy control over the size and stiffness of the resulting CMNPs [ 58 ]. Zhang et al utilized RBC membrane-derived vesicles as nanoreactors to synthesize polymeric cores through in situ polymerization, resulting in cell membrane-coated hydrogel nanoparticles [ 59 ].…”

Section: Synthesis and Surface Engineering Of Cmnpsmentioning

confidence: 99%

Recent Advances in Cell Membrane Coated-Nanoparticles as Drug Delivery Systems for Tackling Urological Diseases

et al. 2023

View full text Add to dashboard Cite

Recent studies have revealed the functional roles of cell membrane coated-nanoparticles (CMNPs) in tackling urological diseases, including cancers, inflammation, and acute kidney injury. Cells are a fundamental part of pathology to regulate nearly all urological diseases, and, therefore, naturally derived cell membranes inherit the functional role to enhance the biopharmaceutical performance of their encapsulated nanoparticles on drug delivery. In this review, methods for CMNP synthesis and surface engineering are summarized. The application of different types of CMNPs for tackling urological diseases is updated, including cancer cell membrane, stem cell membrane, immune cell membrane, erythrocytes cell membranes, and extracellular vesicles, and their potential for clinical use is discussed.

show abstract

“…Natural killer (NK) cells play an important role in the recognition and killing of tumor cells owing to their innate capacity to monitor the abnormal expression of stress proteins and MHC-I [ 50 ]. Although NK cells lack tumor antigen-specific receptors on their surface, they have some alternative receptors that can recognize tumor cells, such as DNAM-1, NKG2D, and NKp46 [ 51 , 52 ]. Therefore, NK cell membrane-wrapped nanoparticles possess good tumor-targeting ability.…”

Section: Biomimetic Cell-derived Nanoparticlesmentioning

confidence: 99%

Biomimetic Cell-Derived Nanoparticles: Emerging Platforms for Cancer Immunotherapy

Huang

Liu

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Cancer immunotherapy can significantly prevent tumor growth and metastasis by activating the autoimmune system without destroying normal cells. Although cancer immunotherapy has made some achievements in clinical cancer treatment, it is still restricted by systemic immunotoxicity, immune cell dysfunction, cancer heterogeneity, and the immunosuppressive tumor microenvironment (ITME). Biomimetic cell-derived nanoparticles are attracting considerable interest due to their better biocompatibility and lower immunogenicity. Moreover, biomimetic cell-derived nanoparticles can achieve different preferred biological effects due to their inherent abundant source cell-relevant functions. This review summarizes the latest developments in biomimetic cell-derived nanoparticles for cancer immunotherapy, discusses the applications of each biomimetic system in cancer immunotherapy, and analyzes the challenges for clinical transformation.

show abstract

Immune cell–camouflaged surface-engineered nanotherapeutics for cancer management

Cited by 10 publications

References 129 publications

Biomimetic Nano-Drug Delivery System: An Emerging Platform for Promoting Tumor Treatment

Biomimetic Nano-Drug Delivery System: An Emerging Platform for Promoting Tumor Treatment

Recent Advances in Cell Membrane Coated-Nanoparticles as Drug Delivery Systems for Tackling Urological Diseases

Biomimetic Cell-Derived Nanoparticles: Emerging Platforms for Cancer Immunotherapy

Contact Info

Product

Resources

About