1983
DOI: 10.1002/eji.1830130915
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Immune capacity of the chicken bursectomized at 60 hours of incubation: transplantation of bone marrow cells of the bursectomized chickens into cyclophosphamide‐treated newly hatched recipients

Abstract: Chickens bursectomized at 60 h of incubation are known to be able to produce immunoglobulins (Ig) but not specific antibodies. In the present work bone marrow (BM) cells of 2- and 10-week-old embryonically bursectomized (Bx) chickens were transferred to newly hatched cyclophosphamide-treated chickens for the purpose of studying whether the transplanted cells home into the bursa and gain a capacity to produce specific antibodies. BM cells of normal 2- and 10-week-old chickens were transferred as controls. Cells… Show more

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Cited by 2 publications
(2 citation statements)
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“…One could predict that in the absence of bursal anlage, precursor B cells might accumulate in the bone marrow of embryo bursectomized (E-Bx) chicks. However, no evidence was obtained that bone marrow cells from 2-and 10-wk-old E-Bx birds were capable of homing into the neonatal bursa of cyclophosphamidetreated birds and restoring the humoral immune system [15]. In the present study we demonstrate by parabiosis and cell transfer experiments the presence of precursor B cells in embryos surgically bursectomized at 72 h of incubation, using sex chromosomes and the genetically polymorphic B cell antigen Bu-1 [16] as markers.…”
Section: Introductionmentioning
confidence: 69%
See 1 more Smart Citation
“…One could predict that in the absence of bursal anlage, precursor B cells might accumulate in the bone marrow of embryo bursectomized (E-Bx) chicks. However, no evidence was obtained that bone marrow cells from 2-and 10-wk-old E-Bx birds were capable of homing into the neonatal bursa of cyclophosphamidetreated birds and restoring the humoral immune system [15]. In the present study we demonstrate by parabiosis and cell transfer experiments the presence of precursor B cells in embryos surgically bursectomized at 72 h of incubation, using sex chromosomes and the genetically polymorphic B cell antigen Bu-1 [16] as markers.…”
Section: Introductionmentioning
confidence: 69%
“…This selective disappearance of prebursal B cell precursors or change in the hemopoietic stem cell population during the late embryonic and early postembryonic period occurred in both normal and Te-treated chick embryos [13]. Recently the presence of precursor B cells was studied in chickens surgically bursectomized at 60 h of incubation [15]. One could predict that in the absence of bursal anlage, precursor B cells might accumulate in the bone marrow of embryo bursectomized (E-Bx) chicks.…”
Section: Introductionmentioning
confidence: 97%