Immune and stress responses in oysters with insights on adaptation

Guo, Ximing; He, Yan; Zhang, Linlin; Lelong, Christophe; Jouaux, Aude

doi:10.1016/j.fsi.2015.05.018

Cited by 149 publications

(121 citation statements)

References 137 publications

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“…Such analysis has been fruitful in previous studies on lophotrochozoans 5 for understanding long-range macrosynteny conservation, but limited in inferring chromosome-scale evolution, as these studies are found in the Pacific oyster Crassostrea gigas but approximately sevenfold higher than that (0.14%) found in humans 17 . As expected, polymorphism in the inbred scallop is greatly reduced compared to that in its hermaphroditic parent (Supplementary Table 11; Fig.…”

Section: Resultsmentioning

confidence: 99%

Scallop genome provides insights into evolution of bilaterian karyotype and development

et al. 2017

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Reconstructing the genomes of bilaterian ancestors is central to our understanding of animal evolution, where knowledge from ancient and/or slow-evolving bilaterian lineages is critical. Here we report a high-quality, chromosome-anchored reference genome for the scallop Patinopecten yessoensis, a bivalve mollusc that has a slow-evolving genome with many ancestral features. Chromosome-based macrosynteny analysis reveals a striking correspondence between the 19 scallop chromosomes and the 17 presumed ancestral bilaterian linkage groups at a level of conservation previously unseen, suggesting that the scallop may have a karyotype close to that of the bilaterian ancestor. Scallop Hox gene expression follows a new mode of subcluster temporal co-linearity that is possibly ancestral and may provide great potential in supporting diverse bilaterian body plans. Transcriptome analysis of scallop mantle eyes finds unexpected diversity in phototransduction cascades and a potentially ancient Pax2/5/8-dependent pathway for noncephalic eyes. The outstanding preservation of ancestral karyotype and developmental control makes the scallop genome a valuable resource for understanding early bilaterian evolution and biology.

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Section: Resultsmentioning

confidence: 99%

Scallop genome provides insights into evolution of bilaterian karyotype and development

et al. 2017

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“…In C. gigas, many gene families related to immune responses are expanded [115,118]. The expansion has resulted in great diversity in sequence, structure and function of immune and stress response genes, which may be central to oysters' remarkable resilience against highly stressful and pathogen-rich environments [6]. In O. bimaculoides, expanded gene families included C2H2 zinc-finger proteins, interleukin-17-like genes, and G-protein-coupled receptors, which may be involved in regulating the immune system [117].…”

Section: Genomes Of Molluscs and Their Parasitesmentioning

confidence: 99%

“…A survey sequence of the pearl oyster has also been published [119], and genomes of C. virginica [120], Pinctada martensii and P. yessoensis are being sequenced. Transcriptomes have been sequenced in many molluscs and identified many genes related to the immune response [6,121,122]. Transcriptomes are often sequenced after challenge with pathogens, and transcriptomic comparison between control and challenged molluscs can suggest the possible involvement of candidate genes in immune responses.…”

Section: Genomes Of Molluscs and Their Parasitesmentioning

confidence: 99%

“…Infection of the Pacific oyster by OsHV-1 alone induces the upregulation of 1942 genes [128]. The large numbers of candidate genes and their possible roles in molluscan immunity have been the subjects of several recent reviews [6,[129][130][131]. Below is a brief summary of the basic components of mollusc's immune response to some important pathogens.…”

Section: Host Immune Responsesmentioning

confidence: 99%

“…As filter-feeders living in microorganism-rich environments, bivalve molluscs may have evolved advanced host-defence mechanisms against pathogens [6]. Recent advances in molecular genetics and genomics have provided insights into the complex molecular machineries involved in host-parasite interactions.…”

Section: Introductionmentioning

confidence: 99%

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Infectious diseases of marine molluscs and host responses as revealed by genomic tools

Guo¹,

Ford²

2016

Phil. Trans. R. Soc. B

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118

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More and more infectious diseases affect marine molluscs. Some diseases have impacted commercial species including MSX and Dermo of the eastern oyster, QPX of hard clams, withering syndrome of abalone and ostreid herpesvirus 1 (OsHV-1) infections of many molluscs. Although the exact transmission mechanisms are not well understood, human activities and associated environmental changes often correlate with increased disease prevalence. For instance, hatcheries and large-scale aquaculture create high host densities, which, along with increasing ocean temperature, might have contributed to OsHV-1 epizootics in scallops and oysters. A key to understanding linkages between the environment and disease is to understand how the environment affects the host immune system. Although we might be tempted to downplay the role of immunity in invertebrates, recent advances in genomics have provided insights into host and parasite genomes and revealed surprisingly sophisticated innate immune systems in molluscs. All major innate immune pathways are found in molluscs with many immune receptors, regulators and effectors expanded. The expanded gene families provide great diversity and complexity in innate immune response, which may be key to mollusc's defence against diverse pathogens in the absence of adaptive immunity. Further advances in host and parasite genomics should improve our understanding of genetic variation in parasite virulence and host disease resistance.

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Diseases, Parasites and the Immune Response

2021

Marine Mussels

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Immune and stress responses in oysters with insights on adaptation

Cited by 149 publications

References 137 publications

Scallop genome provides insights into evolution of bilaterian karyotype and development

Scallop genome provides insights into evolution of bilaterian karyotype and development

Infectious diseases of marine molluscs and host responses as revealed by genomic tools

Diseases, Parasites and the Immune Response

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