Immune and Proliferative Cellular Responses to <i>Helicobacter pylori</i> Infection in the Gastric Mucosa of Mexican Children

Muñoz, Leopoldo; Camorlinga, Margarita; Hernández, Rogelio; Giono, S; Ramon, G; Muñoz, Onofre; Torres, Javier

doi:10.1111/j.1523-5378.2007.00493.x

Cited by 16 publications

(18 citation statements)

References 27 publications

(35 reference statements)

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“…This study and that of Munoz and colleagues [5] found that the quantity of infiltration increased with age. Both studies found a correlation between age and the presence of chronic and acute inflammatory responses to infection.…”

Section: Discussionmentioning

confidence: 63%

Chronic Gastritis Associated with Helicobacter pylori in Mexican Children: Histopathological Patterns

Jaramillo-Rodríguez

Nares-Cisneros²,

Martínez-Ordaz³

et al. 2011

Pediatr Dev Pathol

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The objective of this study was to analyze the histopathological patterns of inflammation, distribution, severity, and degree of gastric mucosa of Helicobacter pylori (Hp)-infected children in Northern Mexico, as well as the correlation between colonization density and inflammation intensity. We carried out a cross-sectional study of gastric biopsies performed on children ranging from 2 to 17 years of age who underwent upper gastrointestinal endoscopy for diverse gastroduodenal disorders. This study includes only children who were found to be Hp carriers, with positive results for tests of Hp antigens in feces and in gastric biopsy studies. We studied 107 patients (age 8.2 ± 3.7 years). In 47.7% of patients, the density of Hp colonization was low; only 21.5% had a marked density. Mononuclear leukocyte infiltration showed a similar distribution. Thirty-seven percent of patients had follicular gastritis. An acute inflammatory response was absent in 65% and mild in 20.6% of patients. When inflammation was present, it was primarily located in the antrum (79%). There were no cases of intestinal metaplasia or atrophy. A link was found between Hp density and age, infiltration by mononuclear cells, the presence of follicular gastritis, and the level of neutrophil infiltration (P = 0.001). Despite the high rates of Hp infection in the region, the histopathological findings in these children were mild and were limited primarily to the antral mucosa. These data indicate the need to study the behavior of this disease in children in diverse study populations to provide localized prevention and treatment strategies.

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Section: Discussionmentioning

confidence: 63%

Chronic Gastritis Associated with Helicobacter pylori in Mexican Children: Histopathological Patterns

Jaramillo-Rodríguez

Nares-Cisneros²,

Martínez-Ordaz³

et al. 2011

Pediatr Dev Pathol

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“…Interestingly, in the two cases where mixed infection was observed with strains differing in their cag PAI status, the cag PAI ϩ strain appeared to be the minority strain. Since the immune responses of children to H. pylori infection appear to differ from those of adults (14,23,34), it is intriguing to speculate that a functional cag PAI may be detrimental to bacterial colonization or persistence in children while enhancing bacterial survival as the immune response matures. A better understanding of the interaction of cag PAI ϩ strains with the pediatric immune system may provide clues as to why a complete cag PAI uniquely predicted development of pediatric ulcer disease compared to other adult H. pylori virulence gene markers.…”

Section: Discussionmentioning

confidence: 99%

PediatricHelicobacter pyloriIsolates Display Distinct Gene Coding Capacities and Virulence Gene Marker Profiles

Talarico

Gold²,

Fero

et al. 2009

J Clin Microbiol

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Helicobacter pylori strains display remarkable genetic diversity, and the presence of strains bearing the toxigenic vacA s1 allele, a complete cag pathogenicity island (PAI), cagA alleles containing multiple EPIYA phosphorylation sites, and expressing the BabA adhesin correlates with development of gastroduodenal disease in adults. To better understand the genetic variability present among pediatric strains and its relationship to disease, we characterized H. pylori strains infecting 47 pediatric North American patients. Prevalence of mixed infection was assessed by random amplified polymorphic DNA analysis of multiple H. pylori clones from each patient. Microarray-based comparative genomic hybridization was used to examine the genomic content of the pediatric strains. The cagA and vacA alleles were further characterized by allele-specific PCR. A range of EPIYA motif configurations were observed for the cagA gene, which was present in strains from 22 patients (47%), but only 19 (41%) patients contained a complete cag PAI. Thirty patients (64%) were infected with a strain having the vacA s1 allele, and 28 patients (60%) had the babA gene. The presence of a functional cag PAI was correlated with ulcer disease (P ‫؍‬ 0.0095). In spite of declining rates of H. pylori infection in North America, at least 11% of patients had mixed infection. Pediatric strains differ in their spectrum of strainvariable genes and percentage of absent genes in comparison to adult strains. Most children were infected with H. pylori strains lacking the cag PAI, but the presence of a complete cag PAI, in contrast to other virulence markers, was associated with more severe gastroduodenal disease.

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“…This appears to be a characteristic feature of H. pylori infection, as gastric mucosal cell proliferation is increased in H. pyloriassociated chronic gastritis but not in chronic gastritis where the organism is absent (Lynch et al, 1995). Study by Munoz et al (2007) also suggests proliferative activity as the epithelial regenerative response to cell damage caused by inflammatory mediators. The initiation of an active inflammatory response.…”

Section: Characteristics Of H Pylori Infectionmentioning

confidence: 99%

Inflammation and proliferation – a causal event of host response to Helicobacter pylori infection

Subhash

2015

Microbiology

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Immune and Proliferative Cellular Responses to Helicobacter pylori Infection in the Gastric Mucosa of Mexican Children

Abstract: Mexican children respond to H. pylori infection with a low inflammatory response, a balanced increase of T and B lymphocytes, and a high regenerative activity.

Cited by 16 publications

References 27 publications

Chronic Gastritis Associated with Helicobacter pylori in Mexican Children: Histopathological Patterns

Chronic Gastritis Associated with Helicobacter pylori in Mexican Children: Histopathological Patterns

PediatricHelicobacter pyloriIsolates Display Distinct Gene Coding Capacities and Virulence Gene Marker Profiles

Inflammation and proliferation – a causal event of host response to Helicobacter pylori infection

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