Immune alterations in acute bipolar depression

Dickerson, Faith; Katsafanas, Emily; Schweinfurth, Lucy; Savage, Christina; Stallings, Cassie; Origoni, Andrea; Khushalani, Sunil; Lillehoj, Erik P.; Yolken, Robert H.

doi:10.1111/acps.12451

Cited by 30 publications

(12 citation statements)

References 45 publications

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“…TNF‐α is a potential biomarker of BD progression. In addition, elevated levels of C‐reactive protein were found during manic episodes as well as in the bipolar depressed group …”

Section: Neuro‐immuno‐endocrinological Approachmentioning

confidence: 99%

Biological hypotheses and biomarkers of bipolar disorder

Sigitova

Fišar

Hroudová

et al. 2017

Psychiatry Clin Neurosci

186

117

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The most common mood disorders are major depressive disorders and bipolar disorders (BD). The pathophysiology of BD is complex, multifactorial, and not fully understood. Creation of new hypotheses in the field gives impetus for studies and for finding new biomarkers for BD. Conversely, new biomarkers facilitate not only diagnosis of a disorder and monitoring of biological effects of treatment, but also formulation of new hypotheses about the causes and pathophysiology of the BD. BD is characterized by multiple associations between disturbed brain development, neuroplasticity, and chronobiology, caused by: genetic and environmental factors; defects in apoptotic, immune-inflammatory, neurotransmitter, neurotrophin, and calcium-signaling pathways; oxidative and nitrosative stress; cellular bioenergetics; and membrane or vesicular transport. Current biological hypotheses of BD are summarized, including related pathophysiological processes and key biomarkers, which have been associated with changes in genetics, systems of neurotransmitter and neurotrophic factors, neuroinflammation, autoimmunity, cytokines, stress axis activity, chronobiology, oxidative stress, and mitochondrial dysfunctions. Here we also discuss the therapeutic hypotheses and mechanisms of the switch between depressive and manic state.

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“…TNF‐α is a potential biomarker of BD progression. In addition, elevated levels of C‐reactive protein were found during manic episodes as well as in the bipolar depressed group …”

Section: Neuro‐immuno‐endocrinological Approachmentioning

confidence: 99%

Biological hypotheses and biomarkers of bipolar disorder

Sigitova

Fišar

Hroudová

et al. 2017

Psychiatry Clin Neurosci

186

117

View full text Add to dashboard Cite

show abstract

“…However, conclusions should be drawn with caution since BP patients are also more prone to TBI compared to healthy controls (Malaspina et al 2001). Identifying the molecular pathways involved in the abnormal immune activation, neuroinflammation, and alteration in neuroplasticity observed in the pathophysiology of the M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT disorder has been the central aim of many recent analyses (e.g., Dickerson et al 2015, Stertz et al 2015.…”

Section: Pro-and Anti-inflammatory Cytokines In Bipolarmentioning

confidence: 99%

Dysregulation of the NF-κB pathway as a potential inducer of bipolar disorder

Elhaik

Zandi

2015

Journal of Psychiatric Research

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“…The crosstalk between inflammatory abnormalities and affective disorders has been extensively investigated from various perspectives, including cytokines, chemokines, antibody titers and immune cell numbers34567. Albeit remarkably diverse, consistent findings exist on the blood level change of several cytokines, especially interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), during the acute or chronic phase of major depression (MD) and bipolar II disorder depression (BD)89.…”

mentioning

confidence: 99%

Circulating T lymphocyte subsets, cytokines, and immune checkpoint inhibitors in patients with bipolar II or major depression: a preliminary study

Zheng

Tian

et al. 2017

Sci Rep

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This study aimed to investigate the less known activation pattern of T lymphocyte populations and immune checkpoint inhibitors on immunocytes in patients with bipolar II disorder depression (BD) or major depression (MD). A total of 23 patients with BD, 22 patients with MD, and 20 healthy controls (HCs) were recruited. The blood cell count of T lymphocyte subsets and the plasma level of cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ) were selectively investigated. The expression of T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), programmed cell death protein 1 (PD-1) and its ligands, PD-L1 and PD-L2, on T lymphocytes and monocytes, was detected. In results, blood proportion of cytotoxic T cells significantly decreased in BD patients than in either MD patients or HCs. The plasma level of IL-6 increased in patients with BD and MD. The expression of TIM-3 on cytotoxic T cells significantly increased, whereas the expression of PD-L2 on monocytes significantly decreased in patients with BD than in HCs. These findings extended our knowledge of the immune dysfunction in patients with affective disorders.

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Immune alterations in acute bipolar depression

Abstract: Individuals with acute bipolar depression show immune alterations. Some of the alterations are similar to those found in acute mania.

Cited by 30 publications

References 45 publications

Biological hypotheses and biomarkers of bipolar disorder

Biological hypotheses and biomarkers of bipolar disorder

Dysregulation of the NF-κB pathway as a potential inducer of bipolar disorder

Circulating T lymphocyte subsets, cytokines, and immune checkpoint inhibitors in patients with bipolar II or major depression: a preliminary study

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