Immune activation in the early puerperium is related to postpartum anxiety and depressive symptoms

Maes, Michaël; Lin, Aihua; Ombelet, Willem; Stevens, K.; Kenis, Günter; Jongh, R. De; Cox, John; Bosmans, Eugène

doi:10.1016/s0306-4530(99)00043-8

Cited by 134 publications

(109 citation statements)

References 45 publications

Supporting

Mentioning

103

Contrasting

Unclassified

Order By: Relevance

“…Maes et al [35] demonstrated that the early puerperium in healthy women is accompanied by an increased inflammatory capacity as compared with the preterm condition. Since the IRS is involved in the pathophysiology of major depression [17] , an increased inflammatory response in the early puerperium could be one of the causal factors underlying PPD.…”

Section: Discussionmentioning

confidence: 99%

Gestational Stress Leads to Depressive-Like Behavioural and Immunological Changes in the Rat

O’Mahony

Myint²,

Hove³

et al. 2006

Neuroimmunomodulation

View full text Add to dashboard Cite

Stress during pregnancy, gestational stress, can increase the chance of developing postpartum depression, which is estimated to occur in 10% of women. Since major depression is accompanied by an activation of the inflammatory response system, the aim of this study was to investigate if stress during pregnancy induces postpartum depressive-like behaviour, and if so, is it accompanied by activation of the inflammatory response system in female Fisher rats. We investigated the effect of gestational stress on the production of depressive-like behaviour in the rats. The pregnant dams underwent daily restraint stress (for 1 week, 3 times/day) or were left undisturbed (control). On postpartum day 22, the rats were introduced to the forced swim test (pre-test). On postpartum days 23 and 24 (test days), the immobility time was measured. Gestational stress significantly elevated immobility scores by 35–40% above the control values on both test days, which suggests that the stressed group displayed postpartum depressive-like behaviour. The concentrations of the pro-inflammatory cytokines interleukin-1β, tumour necrosis factor-α and the anti-inflammatory cytokine interleukin-10 in stimulated whole-blood culture were also analysed. The stressed group showed higher levels of all three cytokines. No significant differences in the cytokine concentrations were detected in the hypothalamus, hippocampus or pre-frontal cortex.

show abstract

Section: Discussionmentioning

confidence: 99%

Gestational Stress Leads to Depressive-Like Behavioural and Immunological Changes in the Rat

O’Mahony

Myint²,

Hove³

et al. 2006

Neuroimmunomodulation

View full text Add to dashboard Cite

show abstract

“…However, these studies compared ''depression reactors'' to ''nonreactors'' -which the authors defined by ranking participants based on q25, median, and q75 values of residualized scores of two symptom severity scales. [17][18][19] This unconventional analysis limits the generalizability of these results. A small study including 27 women with a history of mood or anxiety issues (and therefore at high risk for developing postpartum depression) by Scrandis et al found a significant association between prenatal CRP levels and prenatal depressive symptoms.…”

Section: Introductionmentioning

confidence: 93%

Relationship between inflammatory biomarkers and depressive symptoms during late pregnancy and the early postpartum period: a longitudinal study

Simpson

Steiner

Coote

et al. 2016

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Objective: Perinatal depressive symptoms often co-occur with other inflammatory morbidities of pregnancy. The goals of our study were 1) to examine whether changes in inflammatory markers from the third trimester of pregnancy to 12 weeks postpartum were associated with changes in depressive symptoms; 2) to examine whether third trimester inflammatory markers alone were predictive of postpartum depressive symptoms; and 3) to examine the relationship between inflammatory markers and depressive symptoms during the third trimester of pregnancy and at 12 weeks postpartum. Methods: Thirty-three healthy pregnant women were recruited from the Women's Health Concerns Clinic at St. Joseph's Healthcare in Hamilton, Canada. The impact of depressive symptoms on the levels of interleukin (IL)-6, IL-10, tumor necrosis factor alpha (TNF-a), and C-reactive protein (CRP) at the third trimester of pregnancy, at 12 weeks postpartum, and across time was assessed using linear and mixed-model regression. Results: Regression analysis revealed no significant association between depressive symptoms and any of the candidate biomarkers during pregnancy, at 12 weeks postpartum, or over time. Pregnancy depressive symptoms (p 4 0.001), IL-6 (p = 0.025), and IL-10 (p = 0.006) were significant predictors of postpartum Edinburgh Perinatal Depression Scale (EPDS) score. Conclusions: Our study supports previous reports from the literature showing no relationship between inflammatory biomarkers and depressive symptoms during late pregnancy, early postpartum, or across time. Our study is the first to observe an association between late pregnancy levels of IL-6 and IL-10 and postpartum depressive symptoms. Further studies with larger samples are required to confirm these findings.

show abstract

“…In addition, regardless of mode of delivery, healing processes occur following delivery which may instigate inflammatory responses [57]. In addition to affecting the healing process, functioning of the immune system following childbirth may have clinical implications for risk of postpartum mood disorders [58,59]. Moreover, certain autoimmune diseases including rheumatoid arthritis and multiple sclerosis tend to remit during pregnancy, but become exacerbated at postpartum [60,61].…”

Section: Discussionmentioning

confidence: 99%

33. Longitudinal changes in serum proinflammatory markers across pregnancy and postpartum: Effects of maternal body mass index

Christian

Porter

2014

Brain, Behavior, and Immunity

View full text Add to dashboard Cite

Immune activation in the early puerperium is related to postpartum anxiety and depressive symptoms

Cited by 134 publications

References 45 publications

Gestational Stress Leads to Depressive-Like Behavioural and Immunological Changes in the Rat

Gestational Stress Leads to Depressive-Like Behavioural and Immunological Changes in the Rat

Relationship between inflammatory biomarkers and depressive symptoms during late pregnancy and the early postpartum period: a longitudinal study

33. Longitudinal changes in serum proinflammatory markers across pregnancy and postpartum: Effects of maternal body mass index

Contact Info

Product

Resources

About