Immune Activation and Regulation in Simian Immunodeficiency Virus-Plasmodium fragile-Coinfected Rhesus Macaques

Trott, Kristin A.; Richardson, Amy; Hudgens, Michael; Abel, Kristina

doi:10.1128/jvi.00861-13

Cited by 12 publications

(9 citation statements)

References 69 publications

(102 reference statements)

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“… 91 In one study, HIV infection was observed to be associated with marked blunting of the inflammatory response in a cohort of cerebral malaria in Malawian children. 72 In another study using simian HIV– P. fragile -coinfected macaque models, Trott et al 92 showed that Simian immunodeficiency virus infection promoted elevated IL12 levels, suggesting a shift toward immunoactivation as oppose to immunoregulation, thereby leading to immunodysfunction and exhaustion. This thus translates to increased morbidity in MHC.…”

Section: Impact Of Mhc In Ssamentioning

confidence: 99%

Malaria and HIV coinfection in sub-Saharan Africa: prevalence, impact, and treatment strategies

Kwenti¹

2018

RRTM

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Malaria and HIV, two of the world’s most deadly diseases, are widespread, but their distribution overlaps greatly in sub-Saharan Africa. Consequently, malaria and HIV coinfection (MHC) is common in the region. In this paper, pertinent publications on the prevalence, impact, and treatment strategies of MHC obtained by searching major electronic databases (PubMed, PubMed Central, Google Scholar, ScienceDirect, and Scopus) were reviewed, and it was found that the prevalence of MHC in SSA was 0.7%–47.5% overall. Prevalence was 0.7%–47.5% in nonpregnant adults, 1.2%–27.8% in children, and 0.94%–37% in pregnant women. MHC was associated with an increased frequency of clinical parasitemia and severe malaria, increased parasite and viral load, and impaired immunity to malaria in nonpregnant adults, children, and pregnant women, increased in placental malaria and related outcomes in pregnant women, and impaired antimalarial drug efficacy in nonpregnant adults and pregnant women. Although a few cases of adverse events have been reported in coinfected patients receiving antimalarial and antiretroviral drugs concurrently, available data are very limited and have not prompted major revision in treatment guidelines for both diseases. Artemisinin-based combination therapy and cotrimoxazole are currently the recommended drugs for treatment and prevention of malaria in HIV-infected children and adults. However, concurrent administration of cotrimoxazole and sulfadoxine–pyrimethamine in HIV-infected pregnant women is not recommended, because of high risk of sulfonamide toxicity. Further research is needed to enhance our understanding of the impact of malaria on HIV, drug–drug interactions in patients receiving antimalarials and antiretroviral drugs concomitantly, and the development of newer, safer, and more cost-effective drugs and vaccines to prevent malaria in HIV-infected pregnant women.

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Section: Impact Of Mhc In Ssamentioning

confidence: 99%

Malaria and HIV coinfection in sub-Saharan Africa: prevalence, impact, and treatment strategies

Kwenti¹

2018

RRTM

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“…More recently, various aspects of HIV and malaria co-infections have been studied using P. fragile and the Simian Immunodeficiency Virus as models (Trott et al . 2011, 2013; Frencher et al . 2013).…”

Section: Non-human Malaria Parasites In the Laboratorymentioning

confidence: 99%

Non-human primate malaria parasites: out of the forest and into the laboratory

Martinelli

Culleton

2016

Parasitology

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The study of malaria in the laboratory relies on either the in vitro culture of human parasites, or the use of non-human malaria parasites in laboratory animals. In this review, we address the use of non-human primate malaria parasite species (NHPMPs) in laboratory research. We describe the features of the most commonly used NHPMPs, review their contribution to our understanding of malaria to date, and discuss their potential contribution to future studies.

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“…For example, malaria immunity and susceptibility are reduced in HIV infection (Finney et al, 2013; Hochman & Kim, 2009), and malaria infection triggers HIV viral replication (Hoffman et al, 1999). Subclinical malaria has been associated with elevated markers of immune activation in adults (de Mast et al, 2015), and malaria infection has recently been shown to induce a chronic proinflammatory response among HIV-infected apes (Trott, Richardson, Hudgens, & Abel, 2013). Soil-transmitted helminth infections are also highly endemic in much of sub-Saharan Africa, (Kabatereine et al, 2005; Karagiannis-Voules et al, 2015), induce complex effects on gut and systemic immunity, and unlike HIV, cytomegalovirus (CMV) and malaria, activate Th2 immune responses (Anthony et al, 2007; Salgame, Yap, & Gause, 2013).…”

Section: Chronic Comorbidities and Inflammation With Hiv In Sub-saharmentioning

confidence: 99%

Aging, Health, and Quality of Life for Older People Living With HIV in Sub-Saharan Africa: A Review and Proposed Conceptual Framework

Siedner

2017

J Aging Health

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Differences in traditional, lifestyle, and envirnomental risk factors, as well as unique features of HIV epidemiology and care delivery appear to substantially alter the contribution of HIV to aging in sub-Saharan Africa. Meanwhile, unique preferences and conceptualizations of quality of life will require novel measurement and intervention tools. An expanded research and public health infrastructure is needed to ensure that gains made in HIV prevention and treamtent are translated into long-term benefits in this region.

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Immune Activation and Regulation in Simian Immunodeficiency Virus-Plasmodium fragile-Coinfected Rhesus Macaques

Cited by 12 publications

References 69 publications

Malaria and HIV coinfection in sub-Saharan Africa: prevalence, impact, and treatment strategies

Malaria and HIV coinfection in sub-Saharan Africa: prevalence, impact, and treatment strategies

Non-human primate malaria parasites: out of the forest and into the laboratory

Aging, Health, and Quality of Life for Older People Living With HIV in Sub-Saharan Africa: A Review and Proposed Conceptual Framework

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