Immortelle essential oil-based ointment improves wound healing in a diabetic rat model

Andjić, Marijana; Draginić, Nevena; Kočović, Aleksandar; Jeremić, Jovana; Vucicevic, Ksenija; Jeremić, Nevena; Krstonošić, Velјko; Božin, Biljana; Kladar, Nebojša; Čapo, Ivan; Andrijević, Ljiljana; Pecarski, Danijela; Bolevich, Sergey; Jakovljević, Vladimir; Bradić, Jovana

doi:10.1016/j.biopha.2022.112941

Cited by 15 publications

(10 citation statements)

References 32 publications

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“…Then also the histopathological results validate the wound healing effect of this ointment because it shows a clear increase in collagen fiber density in the post-excision scar [21].…”

Section: Figure 2 Article Exclusion Strategy Flowsupporting

confidence: 60%

“…Hydroxyproline is an amino acid that plays a role in the synthesis, localization and maturation of collagen. In a study, there was a significant increase in the hydroxyproline content in the group treated with H. italicum EOs [12], [21].…”

Section: Figure 2 Article Exclusion Strategy Flowmentioning

confidence: 96%

“…In a study examining the role of fibroblasts in wound healing, one of which was H. italicum EOs, it was found that this oil can induce fibroblasts to induce type I and III collagen deposition during wound healing, thereby accelerating the wound repair process [12], [17], [21]. In the other study, H.…”

Section: Figure 2 Article Exclusion Strategy Flowmentioning

confidence: 99%

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Effectiveness of Helichrysum italicum Essential Oil on Wound Healing

Wijayadi

Kelvin²

2022

J. Food Pharm. Sci

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Helichrysum italicum essential oils (EOs) has long been known as a medicinal agent, especially in wound healing. This is inseparable from the chemical compounds contained in it, such as abundant monoterpenes and sesquiterpenes. The purpose of this systematic review is to examine various studies on the effectiveness of H. italicum EOs on wound healing. Research data searches were conducted through Google Scholar, Proquest, Science Direct, SpringerLink, Wiley Online Library, Taylor & Francis Online and PubMed over the last 10 years by following inclusion and exclusion criteria. Obtained as many as 11 studies that match the criteria. Based on the review of these studies, it was found that H. italicum EOs has good wound healing abilities when viewed from various aspects such as its chemical components, biological activity and its effect on injured body tissues. These chemical components vary in type and amount because they are influenced by various aspects. Biological activities such as antioxidant, antimicrobial, and anti-inflammatory effects have also been shown to be contained in this oil because it affects various phases of wound healing, namely hemostasis, inflammation, proliferation and remodeling phases. This is also inseparable from the accuracy of the type of vehicle used.

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“…Then also the histopathological results validate the wound healing effect of this ointment because it shows a clear increase in collagen fiber density in the post-excision scar [21].…”

Section: Figure 2 Article Exclusion Strategy Flowsupporting

confidence: 60%

Section: Figure 2 Article Exclusion Strategy Flowmentioning

confidence: 96%

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Effectiveness of Helichrysum italicum Essential Oil on Wound Healing

Wijayadi

Kelvin²

2022

J. Food Pharm. Sci

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“…It is widely considered that H. italicum -based products can efficiently delay and even prevent skin aging [ 2 ]. Indeed, numerous studies have shown that essential oil, phenolic and other compounds, present in the plant and its extracts, are desirable preservatives and functional ingredients in cosmetic products due to their antioxidant and antibacterial activity [ 2 ] and their ability to decrease skin irritation [ 3 ] and accelerate wound healing in vivo [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Cyclodextrin-Assisted Extraction of Phenolics from Helichrysum italicum for Preparation of Extracts with Anti-Elastase and Anti-Collagenase Properties

et al. 2023

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Helichrysum italicum is a plant traditionally used for skin-related disorders that is becoming an increasingly popular ingredient in cosmetic products. In this work, a “green” ultrasound-assisted extraction method for H. italicum phenolics was developed using skin-friendly cyclodextrins (CDs). Extraction conditions needed for the greatest yield of target compounds (total phenolics, phenolic acids, and flavonoids) were calculated. The composition of the extracts was determined using LC-MS and spectrophotometric methods. Among the tested CDs, 2-hydroxylpropyl-beta-CD (HP-β-CD) was the best suited for extraction of target phenolics and used to prepare two optimized extracts, OPT 1 (the extract with the highest phenolic acid content) and OPT 2 (the extract with the highest total phenol and flavonoid content). The extracts were prepared at 80 °C, using 0.089 g of plant material/g solvent (0.6 mmol of HP-β-CD), with or without addition of 1.95% (w/w) lactic acid. The main metabolite in both extracts was 3,5-O-dicaffeoylquinic acid. It was found that the addition of lactic acid greatly contributes to the extraction of arzanol, a well-known anti-inflammatory agent. IC50 values of the anti-elastase (22.360 ± 0.125 μL extract/mL and 20.067 ± 0.975 for OPT-1 and OPT-2, respectively) and anti-collagenase (12.035 ± 1.029 μL extract/mL and 14.392 ± 0.705 μL extract/mL for OPT-1 and OPT-2, respectively) activities of the extracts surpassed those of the applied positive controls, namely ursolic and gallic acids. This activity deems the prepared extracts promising ingredients for natural cosmetics, appropriate for direct use in cosmetic products, removing the need for the evaporation of conventional solvents.

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“…Natural products have shown promising properties in the wound healing process through diferent mechanisms of action [4]. Extracts [5][6][7][8], essential oils [9,10], and secondary metabolites [11] isolated from medicinal plants were found to be efective.…”

Section: Introductionmentioning

confidence: 99%

Cedrus deodara: In Vivo Investigation of Burn Wound Healing Properties

Rastegari

Manayi

Akbarzadeh

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Objective. Cedrus deodara (Roxb. Ex Lamb.) G. Don possesses various biological activities, which have been documented in modern and traditional medicine. In this study, burn wound healing activity of the methanol extract of C. deodara wood was evaluated via a burn wound model in Wistar rats. Methods. The methanol extract of C. deodara was evaluated for the contents of phenolic compounds, flavonoids, and tannins. Also, its antioxidant activity was determined using the DPPH assay. Then, a topical ointment containing the methanol extract of C. deodara (10%) was used to evaluate the healing effects on a model of second-degree thermal burn in 4 groups of 7 rats within 21 days. In this respect, average wound surface area, wound closure, and various histological features were examined. Results. Our findings revealed that the wounds treated with the methanol extract of C. deodara showed higher wound contraction (33.6, 87.1, and 93.4% on days 7, 14, and 21, respectively) compared with the positive control (27.6, 80.7, and 88.3% on days 7, 14, and 21, respectively) and the negative control (20.1, 77.9, and 80.2% on days 7, 14, and 21, respectively). According to the results from epitheliogenesis score, the number of inflammatory cells, neovascularization, and collagen density, good burn wound healing activity of the methanol extract of C. deodarawas demonstrated. Conclusion. Using the methanol extract of C. deodara in an ointment formulation can be developed to prevent or reduce burn injury progression.

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Immortelle essential oil-based ointment improves wound healing in a diabetic rat model

Cited by 15 publications

References 32 publications

Effectiveness of Helichrysum italicum Essential Oil on Wound Healing

Effectiveness of Helichrysum italicum Essential Oil on Wound Healing

Optimization of Cyclodextrin-Assisted Extraction of Phenolics from Helichrysum italicum for Preparation of Extracts with Anti-Elastase and Anti-Collagenase Properties

Cedrus deodara: In Vivo Investigation of Burn Wound Healing Properties

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