Immobilizing enoxacin on implant by polyvinyl butyral coating to promote osseointegration in osteoporosis with infection

Bai, Xinxin; Zhang, Xintian; Zhang, Rui; Chen, Wenhao; Wang, Han; Xiao, Jiecheng; Liu, Quan; Weng, Shaohuang; Chen, Min

doi:10.1016/j.matdes.2023.111749

Cited by 5 publications

(2 citation statements)

References 56 publications

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“…Therefore, surface modification of PEEK has become one of the challenges for clinical applications [ 13 ]. This is a way to enhance bioactivity without impacting its overall structure and properties [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Dual aldehyde cross-linked hyaluronic acid hydrogels loaded with PRP and NGF biofunctionalized PEEK interfaces to enhance osteogenesis and vascularization

An,

Shi,

Zhang

et al. 2024

Materials Today Bio

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Section: Introductionmentioning

confidence: 99%

Dual aldehyde cross-linked hyaluronic acid hydrogels loaded with PRP and NGF biofunctionalized PEEK interfaces to enhance osteogenesis and vascularization

An,

Shi,

Zhang

et al. 2024

Materials Today Bio

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“…According to reports, enoxacin (ENX) can inhibit RANKL-induced JNK signaling to reduce osteoclast generation. Bai et al (2023) used polyvinyl butyral (PVB) as the coating medium to modify SPEEK with ENX (SPEEK/PVB-ENX*3). The research found that SPEEK/PVB-ENX*3 can weaken the ability of macrophages co-cultured with the RANKL-inducing factor to fuse into multinucleated osteoclasts.…”

Section: Modification For Enhanced Biopropertiesmentioning

confidence: 99%

State-of-the-art polyetheretherketone three-dimensional printing and multifunctional modification for dental implants

Chen,

Ren,

Shi

et al. 2023

Front. Bioeng. Biotechnol.

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Polyetheretherketone (PEEK) is a high-performance thermoplastic polymer with an elastic modulus close to that of the jawbone. PEEK has the potential to become a new dental implant material for special patients due to its radiolucency, chemical stability, color similarity to teeth, and low allergy rate. However, the aromatic main chain and lack of surface charge and chemical functional groups make PEEK hydrophobic and biologically inert, which hinders subsequent protein adsorption and osteoblast adhesion and differentiation. This will be detrimental to the deposition and mineralization of apatite on the surface of PEEK and limit its clinical application. Researchers have explored different modification methods to effectively improve the biomechanical, antibacterial, immunomodulatory, angiogenic, antioxidative, osteogenic and anti-osteoclastogenic, and soft tissue adhesion properties. This review comprehensively summarizes the latest research progress in material property advantages, three-dimensional printing synthesis, and functional modification of PEEK in the fields of implant dentistry and provides solutions for existing difficulties. We confirm the broad prospects of PEEK as a dental implant material to promote the clinical conversion of PEEK-based dental implants.

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Endowing Polyetheretherketone with Anti‐Infection and Immunomodulatory Properties through Guanidination Carbon Dots Modification to Promote Osseointegration in Diabetes with MRSA Infection

Bai,

Zhang,

Xiao

et al. 2023

Adv Healthcare Materials

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Methicillin‐resistant Staphylococcus aureus (MRSA) infection and compromised immunity are the severe complications associated with implantation surgery in diabetes mellitus. Enhancing the antibacterial and immunomodulatory properties of implants represents an effective approach to improve the osseointegration of implant in diabetes mellitus. Herein, guanidination carbon dots (GCDs) with antibacterial and immunoregulatory functions are synthesized. The GCDs demonstrate killing effect on MRSA without detectable induced resistance. Additionally, they promote the polarization of macrophages from the M1 to M2 subtype, with the inhibiting pro‐inflammatory cytokines and promoting anti‐inflammatory factors. Correspondingly, GCDs are immobilized onto sulfonated polyether ether ketone (SP@GCDs) using a polyvinyl butyraldehyde (PVB) coating layer through soaking‐drying technique. SP@GCDs maintain stable antibacterial efficacy against MRSA for six consecutive days and retain the immunomodulatory function, while also possessing the long‐term storage stability and biocompatibility of more than 6 months. Moreover, SP@GCDs significantly promote the proliferation and mineralization of osteoblasts. SP@GCDs facilitate osteogenesis through immunoregulatory. Additionally, SP@GCDs exert stable antibacterial and immune regulatory functions in implantation site of a diabetes rat, effectively promoting implant osseointegration regardless of the MRSA infection. These findings provide valuable insights into implant modification through designing nanomaterials with multifunction for enhancing osseointegration of diabetes mellitus, suggesting the promising clinical application prospects.

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Immobilizing enoxacin on implant by polyvinyl butyral coating to promote osseointegration in osteoporosis with infection

Cited by 5 publications

References 56 publications

Dual aldehyde cross-linked hyaluronic acid hydrogels loaded with PRP and NGF biofunctionalized PEEK interfaces to enhance osteogenesis and vascularization

Dual aldehyde cross-linked hyaluronic acid hydrogels loaded with PRP and NGF biofunctionalized PEEK interfaces to enhance osteogenesis and vascularization

State-of-the-art polyetheretherketone three-dimensional printing and multifunctional modification for dental implants

Endowing Polyetheretherketone with Anti‐Infection and Immunomodulatory Properties through Guanidination Carbon Dots Modification to Promote Osseointegration in Diabetes with MRSA Infection

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