Immobilized thrombin on X-ray radiopaque polyvinyl alcohol/chitosan embolic microspheres for precise localization and topical blood coagulation

Li, Xiaohong; Ji, Xiongfa; Chen, Kun; Li, Basen; Cao, Jiameng; Xiao, Lin; Xiao, Jun; Yang, Guang

doi:10.1016/j.bioactmat.2020.12.013

Cited by 44 publications

(32 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After double washing with PBS, the dish was observed and imaged by confocal laser scanning microscopy. 9…”

Section: Methodsmentioning

confidence: 99%

“…For BaSO 4 @SH microspheres, compared with SH microspheres, the absorption bands derived from BaSO 4 could be found at 601 and 640 cm À1 in FTIR spectra, which further proves the successful loading of BaSO 4 into the SH microspheres. 9 To further confirm the exact content of BaSO 4 NPs in BaSO 4 @SH microspheres of each group, the TGA analysis was carried out from 30 to 500 1C (Fig. S5b, ESI †).…”

Section: Characterizations Of Baso 4 @Sh Microspheresmentioning

confidence: 99%

“…8 Recently, with the increasing demand in clinical, the study of degradable microspheres has become a hot topic. 1 For example, gelatin sponge particles, poly(ethylene glycol) methacrylate (PEGMA) hydrolyzable microspheres, and polysaccharides microspheres combine a Institute of Smart Biomedical Materials, School of Materials Science and with the functions of radiopaque, 9 drug delivery, 10 and on-demand degradable 11 were studied. The size and size distribution of microspheres are critical factors when treating different diseases with embolization.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The sodium hyaluronate microspheres fabricated by solution drying for transcatheter arterial embolization

Sun

Shen

et al. 2022

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

“…After double washing with PBS, the dish was observed and imaged by confocal laser scanning microscopy. 9…”

Section: Methodsmentioning

confidence: 99%

Section: Characterizations Of Baso 4 @Sh Microspheresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The sodium hyaluronate microspheres fabricated by solution drying for transcatheter arterial embolization

Sun

Shen

et al. 2022

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

“…One conventional approach to endow polymers with X-ray opacity is to blend X-ray absorbing additives, such as metal powders, barium salts, zirconium dioxide, organic iodine compounds, etc [ [12] , [13] , [14] , [15] ]. However, this method suffers from some important defects: (1) the physical, chemical and mechanical properties of polymeric materials are often influenced due to the incorporation of fillers [ 15 ]; (2) it is not easy to blend small-molecule contrast agents evenly with polymers; (3) small-molecule contrast agents easily leach and penetrate into body fluids, resulting in the loss of X-ray opacity and causing systemic toxicities [ 7 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Injectable and thermosensitive hydrogels mediating a universal macromolecular contrast agent with radiopacity for noninvasive imaging of deep tissues

Wang

Chen

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

It is very challenging to visualize implantable medical devices made of biodegradable polymers in deep tissues. Herein, we designed a novel macromolecular contrast agent with ultrahigh radiopacity (iodinate content > 50%) via polymerizing an iodinated trimethylene carbonate monomer into the two ends of poly(ethylene glycol) (PEG). A set of thermosensitive and biodegradable polyester-PEG-polyester triblock copolymers with varied polyester compositions synthesized by us, which were soluble in water at room temperature and could spontaneously form hydrogels at body temperature, were selected as the demonstration materials. The addition of macromolecular contrast agent did not obviously compromise the injectability and thermogelation properties of polymeric hydrogels, but conferred them with excellent X-ray opacity, enabling visualization of the hydrogels at clinically relevant depths through X-ray fluoroscopy or Micro-CT. In a mouse model, the 3D morphology of the radiopaque hydrogels after injection into different target sites was visible using Micro-CT imaging, and their injection volume could be accurately obtained. Furthermore, the subcutaneous degradation process of a radiopaque hydrogel could be non-invasively monitored in a real-time and quantitative manner. In particular, the corrected degradation curve based on Micro-CT imaging well matched with the degradation profile of virgin polymer hydrogel determined by the gravimetric method. These findings indicate that the macromolecular contrast agent has good universality for the construction of various radiopaque polymer hydrogels, and can nondestructively trace and quantify their degradation in vivo . Meanwhile, the present methodology developed by us affords a platform technology for deep tissue imaging of polymeric materials.

show abstract

“…Effective control of early massive bleeding was of great significance for saving lives 1 . Various hemostatic agents have been developed, including synthetic and biological topical hemostatic agents, such as oxidized cellulose, zeolite, gelatin, chitosan, and thrombin sealants 2–7 . However, the hemostatic agents currently used still have limitations, which may cause allergic reactions and are not suitable for prehospital treatment.…”

Section: Introductionmentioning

confidence: 99%

Rapid hemostasis and high bioactivity cerium‐containing mesoporous bioglass for hemostatic materials

et al. 2021

View full text Add to dashboard Cite

A two‐step‐acid‐catalyzed‐self‐assembly method was used to prepare cerium‐containing mesoporous bioactive glass with P123 as a template. The results showed that MBG without cerium and MBG with cerium slightly affected its surface area, and its water absorption rate was significantly higher. In vitro coagulation experiments showed that Ce‐MBG significantly reduces prothrombin time (PT) and activated partial thromboplastin time (APTT), indicating that MBG containing Ce could promote coagulation and platelet adhesion compared with MBG. These suggested that Ce‐MBG may be a good dressing with hemostatic properties, which could shorten the bleeding time of the wound and control the bleeding.

show abstract

Immobilized thrombin on X-ray radiopaque polyvinyl alcohol/chitosan embolic microspheres for precise localization and topical blood coagulation

Cited by 44 publications

References 63 publications

The sodium hyaluronate microspheres fabricated by solution drying for transcatheter arterial embolization

The sodium hyaluronate microspheres fabricated by solution drying for transcatheter arterial embolization

Injectable and thermosensitive hydrogels mediating a universal macromolecular contrast agent with radiopacity for noninvasive imaging of deep tissues

Rapid hemostasis and high bioactivity cerium‐containing mesoporous bioglass for hemostatic materials

Contact Info

Product

Resources

About