Immobilized lipases-based nano-biocatalytic systems — A versatile platform with incredible biotechnological potential

Bilal, Muhammad; Fernandes, Clara Dourado; Mehmood, Tahir; Nadeem, Fareeha; Tabassam, Qudsia; Ferreira, Luiz Fernando Romanholo

doi:10.1016/j.ijbiomac.2021.02.010

Cited by 63 publications

(34 citation statements)

References 159 publications

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“…As shown in Figure 10, these new materials include waste biomaterials, nanomaterials, synthetic resins, mesoporous and electrospun materials. Table 1 also contains detailed information from recent studies [81,[294][295][296]. Biopolymers can offer low cost, easy modification, high surface area, and various functional groups to stabilize lipase conformation [286,294].…”

Section: Novel Carriers For Immobilizationmentioning

confidence: 99%

“…Another possible strategy is to incorporate inorganic materials to produce hybrid biocatalysts with unique properties [297,300,303,310,311]. Similarly, inorganic materials can be conjugated with organic or inorganic substances to produce other hybrid biocatalysts, as mentioned for many kinds of nanomaterials, metal-organic frameworks, mesoporous and ceramic materials [81,295,296,299,301,302,304].…”

Section: Novel Carriers For Immobilizationmentioning

confidence: 99%

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Current Status and Future Perspectives of Supports and Protocols for Enzyme Immobilization

Cavalcante

Sousa

et al. 2021

Catalysts

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The market for industrial enzymes has witnessed constant growth, which is currently around 7% a year, projected to reach $10.5 billion in 2024. Lipases are hydrolase enzymes naturally responsible for triglyceride hydrolysis. They are the most expansively used industrial biocatalysts, with wide application in a broad range of industries. However, these biocatalytic processes are usually limited by the low stability of the enzyme, the half-life time, and the processes required to solve these problems are complex and lack application feasibility at the industrial scale. Emerging technologies create new materials for enzyme carriers and sophisticate the well-known immobilization principles to produce more robust, eco-friendlier, and cheaper biocatalysts. Therefore, this review discusses the trending studies and industrial applications of the materials and protocols for lipase immobilization, analyzing their advantages and disadvantages. Finally, it summarizes the current challenges and potential alternatives for lipases at the industrial level.

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Section: Novel Carriers For Immobilizationmentioning

confidence: 99%

Section: Novel Carriers For Immobilizationmentioning

confidence: 99%

Current Status and Future Perspectives of Supports and Protocols for Enzyme Immobilization

Cavalcante

Sousa

et al. 2021

Catalysts

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“…Biofuels, including biodiesel, have become a renewable alternative to fossil fuels ( Shuba and Kifle, 2018 ; Bilal et al, 2021 ). The production of biodiesel typically relies on animal fat and vegetable oil as biomass; as such, biodiesel a modern source of clean energy ( Filho et al, 2019 ).…”

Section: Heterologous Expression and Molecular Modification Of Microbial Lipasesmentioning

confidence: 99%

A Valuable Product of Microbial Cell Factories: Microbial Lipase

Yao

Liu

et al. 2021

Front. Microbiol.

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As a powerful factory, microbial cells produce a variety of enzymes, such as lipase. Lipase has a wide range of actions and participates in multiple reactions, and they can catalyze the hydrolysis of triacylglycerol into its component free fatty acids and glycerol backbone. Lipase exists widely in nature, most prominently in plants, animals and microorganisms, among which microorganisms are the most important source of lipase. Microbial lipases have been adapted for numerous industrial applications due to their substrate specificity, heterogeneous patterns of expression and versatility (i.e., capacity to catalyze reactions at the extremes of pH and temperature as well as in the presence of metal ions and organic solvents). Now they have been introduced into applications involving the production and processing of food, pharmaceutics, paper making, detergents, biodiesel fuels, and so on. In this mini-review, we will focus on the most up-to-date research on microbial lipases and their commercial and industrial applications. We will also discuss and predict future applications of these important technologies.

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“…Biocatalysts lipases are the most commonly used enzymes in synthetic organic chemistry, and favor the reaction with mild reaction conditions, as well as require low amounts of coenzymes. 6,7 This article reviews the latest research in lipase-catalyzed synthesis of heterocyclic compounds, including five-and six-membered nitrogencontaining and oxygen-containing heterocyclic compounds or others synthesized in recent years, which may provide a valuable reference for green synthesis of heterocyclic compounds.…”

Section: Introductionmentioning

confidence: 99%

Progress in the Synthesis of Heterocyclic Compounds Catalyzed by Lipases

Wang

Shen

et al. 2021

Pharmaceutical Fronts

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Heterocyclic compounds are representative of a larger class of organic compounds, and worthy of attention for many reasons, chief of which is the participation of heterocyclic scaffolds in the skeleton structure of many drugs. Lipases are enzymes with catalytic versatility, and play a key role in catalyzing the reaction of carbon–carbon bond formation, allowing the production of different compounds. This article reviewed the lipase-catalyzed aldol reaction, Knoevenagel reaction, Michael reaction, Mannich reaction, etc., in the synthesis of several classes of heterocyclic compounds with important physiological and pharmacological activities, and also prospected the research focus in lipase-catalyzed chemistry transformations in the future.

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Immobilized lipases-based nano-biocatalytic systems — A versatile platform with incredible biotechnological potential

Cited by 63 publications

References 159 publications

Current Status and Future Perspectives of Supports and Protocols for Enzyme Immobilization

Current Status and Future Perspectives of Supports and Protocols for Enzyme Immobilization

A Valuable Product of Microbial Cell Factories: Microbial Lipase

Progress in the Synthesis of Heterocyclic Compounds Catalyzed by Lipases

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