Immobilized Biocatalyst Technology

Powell, Lawson W.

doi:10.1007/978-94-009-0765-2_11

“…However, the potential application of these bacteria in HCBs control remains to be studied, and it is still essential to identify novel algicidal bacteria to enrich algicidal bacterial resources for the termination of HCBs, especially those at high cell density. Moreover, specific immobilization techniques are crucial to improve the application of algicidal bacteria in the wild because they provide algicidal bacteria with a stable growth environment, thereby helping them to control HCBs [ 9 – 13 ]. Although immobilization techniques have several advantages, including high reproducibility and high stability, certain problems associated with their use, such as the reduction of bacterial activity, need to be resolved.…”

Section: Introductionmentioning

confidence: 99%

Wheat Bran Enhances the Cytotoxicity of Immobilized Alcaligenes aquatilis F8 against Microcystis aeruginosa

Sun

¹

,

Lin

²

,

Wang

³

et al. 2015

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Algicidal bacteria offer a promising option for killing cyanobacteria. Therefore, a new Alcaligenes aquatilis strain F8 was isolated to control Microcystis aeruginosa in this study. The algicidal activity of strain F8 was dependent on the cell density of M. aeruginosa, and the maximal algicidal rate of the free bacterium reached 88.45% within 72 h. With a view to its application to the control of M. aeruginosa in the natural environment, strain F8 was immobilized in sodium alginate beads, but immobilization of the strain decreased its algicidal rate compared to that of the free bacterium. However, addition of wheat bran to the sodium alginate matrix used to immobilize strain F8 not only eliminated the adverse effects of immobilization on the bacteria but also resulted in an 8.83% higher algicidal rate of the immobilized than free bacteria. Exclusion and recovery methods were used to identify key ingredients of wheat bran and gain insight into the mechanism underlying the observed enhancement of algicidal activity. This analysis indicated that certain factors in wheat bran, including vitamins B1, B2, B9, and E were responsible for promoting bacterial growth and thereby improving the algicidal rate of immobilized strain F8. Our findings indicate that wheat bran is able to improve the algicidal efficiency of A. aquatilis strain F8 for killing M. aeruginosa and is a good source of not only carbon and nitrogen but also vitamins for bacteria.

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“…Cell immobilization by means of biomass entrapment [11] within various hydrogels is one of the progressive approaches, for the creation of immobilized biocatalyst [12,13]. Many diverse gel matrices have been proposed as possible carriers.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Study of MefenamateStarch as Drug Delivery System

Journal¹

2013

Baghdad Sci.J

0

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Mefenamic acid was esterified with starchwith[1:1] Molar ratio, as drug substituted with natural polymer, to prolongthe period of hydrolysis of drug polymer with other advantages. The new prodrug starch was characterized by FT-IR and UV-Visible and 1H-NMR spectroscopies. The physical properties were studied and controlled drug release was studied in different pH values at 37oC. The stability of drug was carried out by measuring the absorbance of mefenamic starch which hydrolyzed in HCl solution of pH 1.1 (artificial gastric fluid) and phosphate buffer of pH 7.4 (simulating intestinal fluid SIF) at 37oC for several days. The thermal analysis such as DSC was studied.

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“…Cell immobilization by means of biomass entrapment [11] within various hydrogels is one of the progressive approaches, for the creation of immobilized biocatalyst [12,13]. Many diverse gel matrices have been proposed as possible carriers.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Study of MefenamateStarch as Drug Delivery System

Ali,

Rahi,

Q. M

et al. 2013

Baghdad Sci.J

0

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Mefenamic acid was esterified with starchwith[1:1] Molar ratio, as drug substituted with natural polymer, to prolongthe period of hydrolysis of drug polymer with other advantages. The new prodrug starch was characterized by FT-IR and UV-Visible and 1H-NMR spectroscopies. The physical properties were studied and controlled drug release was studied in different pH values at 37oC. The stability of drug was carried out by measuring the absorbance of mefenamic starch which hydrolyzed in HCl solution of pH 1.1 (artificial gastric fluid) and phosphate buffer of pH 7.4 (simulating intestinal fluid SIF) at 37oC for several days. The thermal analysis such as DSC was studied.

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Immobilized Biocatalyst Technology

Cited by 6 publications

References 124 publications

Wheat Bran Enhances the Cytotoxicity of Immobilized Alcaligenes aquatilis F8 against Microcystis aeruginosa

Wheat Bran Enhances the Cytotoxicity of Immobilized Alcaligenes aquatilis F8 against Microcystis aeruginosa

In Vitro Study of MefenamateStarch as Drug Delivery System

In Vitro Study of MefenamateStarch as Drug Delivery System

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