Immobilization of Tripeptide Growth Factor Glycyl-L-histidyl-L-lysine on Poly(vinylalcohol)-quarternized Stilbazole(PVA-SbQ) and Its Use as a Ligand for Hepatocyte Attachment.

Kawase, Masaya; Miura, Nagamitsu; Kurikawa, Nobuya; Masuda, Kazuyuki; Higashiyama, Shigeki; Yagi, Kiyohito; Mizoguchi, Tadashi

doi:10.1248/bpb.22.999

Cited by 8 publications

(4 citation statements)

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“…122 Oligopeptide sequences have been introduced onto the surface of PVA gels to enhance cellular interaction. For example, a Gly-His-Lys sequence responsible for hepatocyte attachment, 123 and an RGDS sequence for the adhesion of corneal epithelial cells 124 have been investigated.…”

Section: Poly(vinyl Alcohol)mentioning

confidence: 99%

Hydrogels for Tissue Engineering

2001

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Section: Poly(vinyl Alcohol)mentioning

confidence: 99%

Hydrogels for Tissue Engineering

2001

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“…1). Also, PVA gels have been modified to enhance cellular adhesion by incorporation of GHK [58] or RGDS [59] sequences for adhesion of hepatocytes and epithelial cells, respectively. In addition, the degradation property of hydrogels may be modified through incorporation of degradable linkers.…”

Section: Biohybrid Hydrogelsmentioning

confidence: 99%

Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology

et al. 2006

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Hydrophilic polymers are the center of research emphasis in nanotechnology because of their perceived “intelligence”. They can be used as thin films, scaffolds, or nanoparticles in a wide range of biomedical and biological applications. Here we highlight recent developments in engineering uncrosslinked and crosslinked hydrophilic polymers for these applications. Natural, biohybrid, and synthetic hydrophilic polymers and hydrogels are analyzed and their thermodynamic responses are discussed. In addition, examples of the use of hydrogels for various therapeutic applications are given. We show how such systems' intelligent behavior can be used in sensors, microarrays, and imaging. Finally, we outline challenges for the future in integrating hydrogels into biomedical applications.

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“…Finally, GHK has been shown to be able to serve as a cell adhesion molecule, which means that it helps cells to attach themselves to the extracellular matrix. This facilitates migration, proliferation, and differentiation of repair cells in the skin [ 53 , 54 ].…”

Section: Biochemistry Of Ghk-cumentioning

confidence: 99%

GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration

Pickart¹,

Vasquez-Soltero²,

Margolina³

2015

BioMed Research International

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GHK (glycyl-L-histidyl-L-lysine) is present in human plasma, saliva, and urine but declines with age. It is proposed that GHK functions as a complex with copper 2+ which accelerates wound healing and skin repair. GHK stimulates both synthesis and breakdown of collagen and glycosaminoglycans and modulates the activity of both metalloproteinases and their inhibitors. It stimulates collagen, dermatan sulfate, chondroitin sulfate, and the small proteoglycan, decorin. It also restores replicative vitality to fibroblasts after radiation therapy. The molecule attracts immune and endothelial cells to the site of an injury. It accelerates wound-healing of the skin, hair follicles, gastrointestinal tract, boney tissue, and foot pads of dogs. It also induces systemic wound healing in rats, mice, and pigs. In cosmetic products, it has been found to tighten loose skin and improve elasticity, skin density, and firmness, reduce fine lines and wrinkles, reduce photodamage, and hyperpigmentation, and increase keratinocyte proliferation. GHK has been proposed as a therapeutic agent for skin inflammation, chronic obstructive pulmonary disease, and metastatic colon cancer. It is capable of up- and downregulating at least 4,000 human genes, essentially resetting DNA to a healthier state. The present review revisits GHK's role in skin regeneration in the light of recent discoveries.

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Immobilization of Tripeptide Growth Factor Glycyl-L-histidyl-L-lysine on Poly(vinylalcohol)-quarternized Stilbazole(PVA-SbQ) and Its Use as a Ligand for Hepatocyte Attachment.

Cited by 8 publications

References 0 publications

Hydrogels for Tissue Engineering

Hydrogels for Tissue Engineering

Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology

GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration

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