Immobilization of mycotoxins on modified nanodiamond substrates

Gibson, Natalie M.; Luo, Tzy Jiun Mark; Brenner, Donald W.; Shenderova, Olga

doi:10.1116/1.3672489

Cited by 40 publications

(17 citation statements)

References 44 publications

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“…The adsorption capacity was estimated for AFL B1 as approximately 10 μg per mg of nanodiamonds and for OTA around 15 μg per mg of nanodiamonds. These results indicate greater adsorption capacities than commercially used yeast cell walls and clay minerals [ 95 ].…”

Section: Nano Approaches For Mycotoxin Risk Eliminationmentioning

confidence: 96%

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

et al. 2018

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Mycotoxins are toxic secondary metabolites produced by certain filamentous fungi. The occurrence of mycotoxins in food and feed causes negative health impacts on both humans and animals. Clay binders, yeast cell walls, or antioxidant additives are the most widely used products for mycotoxin elimination to reduce their impact. Although conventional methods are constantly improving, current research trends are looking for innovative solutions. Nanotechnology approaches seem to be a promising, effective, and low-cost way to minimize the health effects of mycotoxins. This review aims to shed light on the critical knowledge gap in mycotoxin elimination by nanotechnology. There are three main strategies: mold inhibition, mycotoxin adsorption, and reducing the toxic effect via nanoparticles. One of the most promising methods is the use of carbon-based nanomaterials. Graphene has been shown to have a huge surface and high binding capacity for mycotoxins. Attention has also been drawn to polymeric nanoparticles; they could substitute adsorbents or enclose any substance, which would improve the health status of the organism. In light of these findings, this review gives new insights into possible future research that might overcome challenges associated with nanotechnology utilization for mycotoxin elimination from agricultural products.

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Section: Nano Approaches For Mycotoxin Risk Eliminationmentioning

confidence: 96%

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

et al. 2018

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“…Fungi used to cause several diseases in domestic animals by producing mycotoxins. Gibson et al developed methods of immobilization of mycotoxins, such as aflatoxin B1 (AfB1) and ochratoxin A (OTA) by modified nanodiamond substrates through various mechanistic approaches, including carboxylation, hydrogenation, and hydroxylation [ 206 ].…”

Section: Types Of Various Nanomaterials Used In Veterinary Medicinmentioning

confidence: 99%

Theranostics Aspects of Various Nanoparticles in Veterinary Medicine

Bai

Lin

Huang

et al. 2018

IJMS

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Nanoscience and nanotechnology shows immense interest in various areas of research and applications, including biotechnology, biomedical sciences, nanomedicine, and veterinary medicine. Studies and application of nanotechnology was explored very extensively in the human medical field and also studies undertaken in rodents extensively, still either studies or applications in veterinary medicine is not up to the level when compared to applications to human beings. The application in veterinary medicine and animal production is still relatively innovative. Recently, in the era of health care technologies, Veterinary Medicine also entered into a new phase and incredible transformations. Nanotechnology has tremendous and potential influence not only the way we live, but also on the way that we practice veterinary medicine and increase the safety of domestic animals, production, and income to the farmers through use of nanomaterials. The current status and advancements of nanotechnology is being used to enhance the animal growth promotion, and production. To achieve these, nanoparticles are used as alternative antimicrobial agents to overcome the usage alarming rate of antibiotics, detection of pathogenic bacteria, and also nanoparticles being used as drug delivery agents as new drug and vaccine candidates with improved characteristics and performance, diagnostic, therapeutic, feed additive, nutrient delivery, biocidal agents, reproductive aids, and finally to increase the quality of food using various kinds of functionalized nanoparticles, such as liposomes, polymeric nanoparticles, dendrimers, micellar nanoparticles, and metal nanoparticles. It seems that nanotechnology is ideal for veterinary applications in terms of cost and the availability of resources. The main focus of this review is describes some of the important current and future principal aspects of involvement of nanotechnology in Veterinary Medicine. However, we are not intended to cover the entire scenario of Veterinary Medicine, despite this review is to provide a glimpse at potential important targets of nanotechnology in the field of Veterinary Medicine. Considering the strong potential of the interaction between the nanotechnology and Veterinary Medicine, the aim of this review is to provide a concise description of the advances of nanotechnology in Veterinary Medicine, in terms of their potential application of various kinds of nanoparticles, secondly we discussed role of nanomaterials in animal health and production, and finally we discussed conclusion and future perspectives of nanotechnology in veterinary medicine.

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“…In addition, aromatic ring of eugenol has π-π interaction with the carbon surface of ND. 54,55 Since eugenol is a small molecule compared to protein and other chemical drugs, π-π interaction between ND and eugenol might not be dependent on facet size of ND, which makes eugenol easily approach ND surface. Hydrogen bonding and π-π interaction between eugenol and ND led the effective drug adsorption up to 80%.…”

Section: Quartz Crystal Microbalancementioning

confidence: 99%

Comprehensive evaluation of carboxylated nanodiamond as a topical drug delivery system

Lim¹,

Kim²,

Kang³

et al. 2016

IJN

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The best strategy in the development of topical drug delivery systems may be to facilitate the permeation of drugs without any harmful effects, while staying on the skin surface and maintaining stability of the system. Nanodiamonds (NDs) play a key role with their excellent physicochemical properties, including high biocompatibility, physical adsorption, reactive oxygen species (ROS) scavenging capability, and photostabilizing activity. Z -average sizes of carboxylated ND (ND–COOH) agglutinate decreased significantly as the pH increased. Fluorescein-conjugated ND was observed only on the stratum corneum, and no sample diffused into the dermal layer even after 48 hours. Moreover, ND–COOH and ND–COOH/eugenol complex did not show significant toxic effects on murine macrophage cells. ND improved in vitro skin permeation >50% acting as a “drug reservoir” to maintain a high drug concentration in the donor chamber, which was supported by quartz crystal microbalance results. Moreover, ND–COOH could adsorb a drug amount equivalent to 80% of its own weight. A photostability study showed that ND–COOH increased the photostability ~47% with regard to rate constant of the eugenol itself. A significant decrease in ROS was observed in the ND–COOH and ND–COOH/eugenol complex compared with the negative control during intracellular ROS assay. Moreover, ROS and cupric reducing antioxidant capacity evaluation showed that ND–COOH had synergistic effects of antioxidation with eugenol. Therefore, ND–COOH could be used as an excellent topical drug delivery system with improved permeability, higher stability, and minimized safety issue.

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Immobilization of mycotoxins on modified nanodiamond substrates

Cited by 40 publications

References 44 publications

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

Theranostics Aspects of Various Nanoparticles in Veterinary Medicine

Comprehensive evaluation of carboxylated nanodiamond as a topical drug delivery system

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