Immobilization of invertase in calcium alginate and calcium alginate-kappa-carrageenan beads and its application in bioethanol production

Malhotra, Ishita; Basir, Seemi Farhat

doi:10.1080/10826068.2019.1709979

Cited by 24 publications

(12 citation statements)

References 23 publications

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“…Chitosan and κ carrageenan were used to encapsulate NSO using three different cross-linkers (i.e., genipin, glutaraldehyde and tannic acid) to compare their effect on the release behaviour of the microcapsules. Therein, glutaraldehyde was found to be the best cross-linker to improve thermal stability, release behaviour and water uptake capacity of chitosan microcapsules [39]. Both FTIR and the DSC analyses confirmed the absence of chemical interaction in microcapsules, but the release of NSO was entirely dependent on the cross-linker.…”

Section: Chitosan Encapsulation Of Neem Seed Oilmentioning

confidence: 85%

Recent developments in chitosan encapsulation of various active ingredients for multifunctional applications

Raza

Khalil

Ayub

et al. 2020

Carbohydrate Research

134

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Microencapsulation being an emerging technique has provided effective solution to the challenges faced by pharmaceutical, cosmetic, food agriculture and textile industries to deliver ingredients in their active forms to the target sites. Chitosan is a non-toxic, biodegradable and biocompatible amino polysaccharide which makes it useful for the encapsulation of various active ingredients with positive potential applications. Chitosan coating on food products, for example, gives them protection from possible antimicrobial attacks, antioxidants and extended shelf life. Likewise, its coating on pharmaceutics has valuable applications in preservation dn targeted drug delivery. In this review, we discuss the formation of chitosan, its properties, microencapsulation process, micro-capsular morphologies, selection of core and shell materials in addition to the process of chitosan encapsulation of various active ingredients and their applications in various fields of science and technology.

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Section: Chitosan Encapsulation Of Neem Seed Oilmentioning

confidence: 85%

Recent developments in chitosan encapsulation of various active ingredients for multifunctional applications

Raza

Khalil

Ayub

et al. 2020

Carbohydrate Research

134

View full text Add to dashboard Cite

show abstract

“…Much research on enzyme entrapment uses a κ-carrageenan as a wall material, such as for the entrapment of invertase [ 76 ], alpha-amylase [ 49 ], papain [ 50 ], urease [ 77 ], pancreatin [ 78 ], lactase [ 79 ], lipase [ 80 , 81 ], and glucoamylase [ 82 ].…”

Section: Most Used Polymers For Enzyme Encapsulationmentioning

confidence: 99%

Polymers as Encapsulating Agents and Delivery Vehicles of Enzymes

et al. 2021

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Enzymes are versatile biomolecules with broad applications. Since they are biological molecules, they can be easily destabilized when placed in adverse environmental conditions, such as variations in temperature, pH, or ionic strength. In this sense, the use of protective structures, as polymeric capsules, has been an excellent approach to maintain the catalytic stability of enzymes during their application. Thus, in this review, we report the use of polymeric materials as enzyme encapsulation agents, recent technological developments related to this subject, and characterization methodologies and possible applications of the formed bioactive structures. Our search detected that the most explored methods for enzyme encapsulation are ionotropic gelation, spray drying, freeze-drying, nanoprecipitation, and electrospinning. α-chymotrypsin, lysozyme, and β-galactosidase were the most used enzymes in encapsulations, with chitosan and sodium alginate being the main polymers. Furthermore, most studies reported high encapsulation efficiency, enzyme activity maintenance, and stability improvement at pH, temperature, and storage. Therefore, the information presented here shows a direction for the development of encapsulation systems capable of stabilizing different enzymes and obtaining better performance during application.

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“…Penggunaan dalam formulasi obat dapat dimanfaatkan untuk mengenkapsulasi bahan aktif yang bertujuan untuk memproteksi dari degradasi (60) , mengontrol pelepasan zat aktif, meningkatkan absorpsi air selama swelling (20) , meningkatkan sifat mekanik mikrobeads (61) , memproteksi dari cairan lambung, serta meningkatkan efisiensi enkapsulasi (62) . Kombinasi alginat dengan karagenan telah banyak digunakan dalam formulasi mengenkapsulasi bahan aktif yang bertujuan untuk meningkatkan efektivitas zat aktif (47,63) , meningkatkan kekuatan mekanik (19,64) , memiliki kapasitas adsorpsi yang baik (64) , mengontrol lipid digesti (65) , mengontrol pelepasan zat aktif (6,(66)(67)(68)(69)(70)(71)(72)(73) , meningkatkan stabilitas (74)(75)(76) , meningkatkan stabilitas tekstur (77) , meningkatkan efesiensi enkapsulasi (74,78) , meningkatkan kekuatan mekanik dan biologis (79,80) , serta sebagai pembawa obat tertarget (73) .…”

Section: Pemanfaatan Kombinasi Polimerunclassified

“…Kombinasi algiant dan karagenan sebagai matriks untuk invertase enzim juga bermanfaat untuk mengatasi masalah kebocoran pada enzim dengan meningkatkan kekuatan mekanik dan stabilitas dari bead alginat (76) .…”

Section: Pemanfaatan Kombinasi Polimerunclassified

Review Sinergisitas Kombinasi Polimer Alami Serta Pemanfaatan dalam Formulasi Obat

et al. 2021

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Pengetahuan tentang sinergisme bermanfaat untuk menentukan kombinasi polimer alami yang memberikan efek menguntungkan ketika dikombinasikan. Interaksi yang saling menguntungkan antar polimer alami dapat dilihat dari nilai sinergisitas dari data pengujian viskositas. Kombinasi polimer yang memiliki efek sinergi dapat memberikan banyak kegunaan serta manfaat yang besar dalam pengembangan teknologi formulasi obat sehingga dapat mengatasi kekurangan yang dimiliki oleh masing-masing zat aktif obat. Pada studi ini, dilakukan review artikel tentang sinergisme kombinasi polimer, pengaruh kation sebagai cross-linker, serta aplikasi kombinasi alginat dengan polimer alami dalam formulasi sediaan obat dan aspek farmakologinya. Database yang digunakan untuk mengambil referensi, meliputi Scopus, PubMed, dan Google Schoolar. Tipe data dari database meliputi jurnal, artikel review, maupun buku tanpa ada pembatasan tahun. Referensi yang diperoleh dari database lalu diidentifikasi, dianalisis, dan dipilih yang sesuai dengan topik yang akan direview. Formulasi dengan polimer menghasilkan obat dengan pelepasan terkontrol, yang memiliki keuntungan, yakni dapat menurunkan frekuensi pemberian dosis, menurunkan efek samping obat, meningkatkan tingkat kepatuhan pasien, menurunkan fluktuasi, serta memperlama durasi aksi obat, dan memastikan respon farmakokinetik dan farmakodinamik dapat reprodusibel dan diprediksi. Selain itu, polimer dapat pula dimodifikasi sedemikian rupa untuk menjadi sistem penghantaran obat tertarget pada organ tertentu. Polimer alami yang paling banyak digunakan dan dikombinasikan dengan polimer lain adalah alginat karena memiliki struktur dengan banyak gugus negatif berupa karboksil dan hidroksil sehingga memiliki berbagai keuntungan, seperti dapat meningkatkan kelarutan obat, meningkatkan kemampuan mukoadesif, melepaskan obat secara terkontrol, serta menghantarkan obat pada target organ tertentu.

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Immobilization of invertase in calcium alginate and calcium alginate-kappa-carrageenan beads and its application in bioethanol production

Cited by 24 publications

References 23 publications

Recent developments in chitosan encapsulation of various active ingredients for multifunctional applications

Recent developments in chitosan encapsulation of various active ingredients for multifunctional applications

Polymers as Encapsulating Agents and Delivery Vehicles of Enzymes

Review Sinergisitas Kombinasi Polimer Alami Serta Pemanfaatan dalam Formulasi Obat

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