Immersion Vaccination by a Biomimetic-Mucoadhesive Nanovaccine Induces Humoral Immune Response of Red Tilapia (Oreochromis sp.) against Flavobacterium columnare Challenge

Kitiyodom, Sirikorn; Yata, Teerapong; Thompson, Kim D.; Costa, Janina Z.; Elumalai, Preetham; Katagiri, Takayuki; Temisak, Sasithon; Namdee, Katawut; Rodkhum, Channarong; Pirarat, Nopadon

doi:10.3390/vaccines9111253

Cited by 21 publications

(16 citation statements)

References 47 publications

(71 reference statements)

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“…There was also evidence that these nanoparticles induced changes in the mucosal‐associated lymphoid tissue. In a more recent study, a significant up‐regulation of igm and igt transcripts was observed in the spleen and kidney of red tilapia vaccinated with the chitosan complex nanoemulsion when infected with F. columnare , demonstrating that the chitosan‐based mucoadhesive vaccine could generate a humoral systemic immune response against columnaris disease in fish vaccinated by immersion 81,82 . Studies have also shown the prophylactic efficacy of nanovaccines against fish viral diseases.…”

Section: Advancements In Nanoparticle Technologies For Tilapia Vaccinesmentioning

confidence: 94%

“…Some other examples of nanoparticles used to delivery vaccines in aquaculture include the studies by Kitiyodom et al, 69,81,82 who examined the efficacy of chitosan-coated mucoadhesive nanovaccine against columnaris disease delivered to farmed red tilapia by immersion vaccination. This disease is caused by Flavobacterium columnare.…”

Section: Advancements In Nanoparticle Technologies For Tilapia Vaccinesmentioning

confidence: 99%

“…In a more recent study, a significant up-regulation of igm and igt transcripts was observed in the spleen and kidney of red tilapia vaccinated with the chitosan complex nanoemulsion when infected with F. columnare, demonstrating that the chitosan-based mucoadhesive vaccine could generate a humoral systemic immune response against columnaris disease in fish vaccinated by immersion. 81,82 Studies have also shown the prophylactic efficacy of nanovaccines against fish viral diseases. A targeted single-walled carbon nanotubes-based immersion vaccine delivery system (CNTs-M-VP7) has been studied to provide strong immune response in vaccinated fish and could be a potential strategy for prophylaxis against fish viral diseases.…”

Section: Advancements In Nanoparticle Technologies For Tilapia Vaccinesmentioning

confidence: 99%

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Tilapia lake virus disease: Vaccine strategies to control the threat to tilapia aquaculture

Lakshmi¹,

Smith

Dong

et al. 2023

Reviews in Aquaculture

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Since the first report of a novel disease caused by tilapia lake virus (TiLV) in 2014, the disease (TiLVD) has gained considerable attention as one of the most devastating viral diseases in tilapia aquaculture globally. The virus is both highly virulent and transmissible and has been detected in many countries worldwide. It poses a severe threat to the global tilapia aquaculture industry, food security and many people's livelihoods in low and middle‐income countries. The absence of effective treatment strategies and inadequate biosecurity measures means the virus's rapid spread is likely to continue. Vaccination has proven to be an effective approach to preventing and controlling disease in finfish aquaculture. The vaccine's efficacy and the delivery system's suitability are essential for evoking an appropriate immune response against the pathogen. The purpose of this review is to provide an overview of the strategies being used to develop vaccines for TiLVD. Nanovaccines, which offer a new approach to prevent TiLVD in farmed tilapia, are also discussed.

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Section: Advancements In Nanoparticle Technologies For Tilapia Vaccinesmentioning

confidence: 94%

Section: Advancements In Nanoparticle Technologies For Tilapia Vaccinesmentioning

confidence: 99%

Section: Advancements In Nanoparticle Technologies For Tilapia Vaccinesmentioning

confidence: 99%

See 1 more Smart Citation

Tilapia lake virus disease: Vaccine strategies to control the threat to tilapia aquaculture

Lakshmi¹,

Smith

Dong

et al. 2023

Reviews in Aquaculture

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“…Gram-negative motile aeromonads may be treated with potassium permanganate (KMnO 4 ) and with antibiotics in the feed (Monir et al 2020;Prabu et al 2019;Stratev and Odeyemi 2017). A recent study reported immersion vaccination against columnaris disease induced a strong immune response and improved survival against experimental infection of F. columnare (Kitiyodom et al 2021). This opportunistic pathogen, in addition to fungal diseases such as white spots, can also be effectively treated via exposure to CuSO 4 , KMnO 4 , or salt/sodium chloride (El-Sayed 2020;Prabu et al 2019).…”

Section: Diseases and Their Treatments In Tilapia Farmingmentioning

confidence: 99%

Tilapia aquaculture, emerging diseases, and the roles of the skin microbiomes in health and disease

et al. 2023

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Aquaculture is playing an increasingly important role in global food security, especially for low-income and food-deficit countries. The majority of aquaculture production occurs in freshwater earthen ponds and tilapia has quickly become one of the most widely adopted culture species in these systems. Tilapia are now farmed in over 140 countries facilitated by their ease of production, adaptability to a wide range of environmental conditions, fast growth, and high nutritional value. Typically, tilapia have been considered a hardy, disease resilient species; however, the disease is increasing with subsequent threats to the industry as their production is intensified. In this review, we discuss tilapia production, with a focus on Bangladesh as one of the top producing countries, and highlight the problems associated with disease and treatment approaches for them, including the misuse of antimicrobials. We address a key missing component in understanding health and disease processes for sustainable production in aquaculture, specifically the role played by the microbiome. Here we examine the importance of the microbiome in supporting health, focused on the symbiotic microbial community of the fish skin mucosal surface, the abiotic and biotic factors that influence the microbiome, and the shifts that are associated with diseased states. We also identify conserved taxa of skin microbiomes that may be used as indicators of health status for tilapia offering new opportunities to mitigate and manage the disease and optimize environmental growing conditions and farming practices.

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“…94,96,100 The mucosal-associated lymphoid tissues (MALTs) are important in preventing pathogen invasion into the fish during the early stages of infection and are associated with skin (skin-associated lymphoid tissue [SALT]), gut (gut-associated lymphoid tissue [GALT]), gills (gill associated lymphoid tissues [GIALT]) and nares (nasopharynxassociated lymphoid tissue [NALT]). 55,101 While the contribution of MALTs in tilapia immunity has not yet been fully elucidated, mucosal vaccination of tilapia with a nanoparticle vaccine against F. columnare, delivered by immersion, was shown to trigger upregulation of IgT, IgM, TNF α, IL1-β and MHC-1 in the gills (mucosal response) 102 and of IgT, IgM, TNF α and IL1-β in the blood (systemic response) 103 of vaccinated fish.…”

Section: Immune System In Tilapiamentioning

confidence: 99%

Strategies to enhance tilapia immunity to improve their health in aquaculture

Wang

Thompson

Wangkahart

et al. 2022

Reviews in Aquaculture

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Various emerging and re-emerging diseases, such as streptococcosis, tilapia lake virus disease and infectious spleen and kidney necrosis virus disease, have had a significant economic impact on the tilapia industry over the last decade. These diseases have resulted in high levels of morbidity and mortality, production losses and trade restrictions. In the absence of effective husbandry management, disease prevention strategies and appropriate biosecurity measures, infectious diseases will continue to challenge the sustainability of global tilapia aquaculture. Strategies used to reduce the impact of disease include feeding probiotic and prebiotic supplements to enhance tilapia health and to modulate the fish's gut microbiota to improve gut health. Herbal medicines and immunostimulants are also used to enhance immunity to disease, while vaccines are available, or are under development, for a number of economically important pathogens affecting tilapia culture. This review provides an overview of the benefits of enhancing the immune response of tilapia to improve their health, and in turn reduce the levels of pathogens within tilapia farming systems.

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Immersion Vaccination by a Biomimetic-Mucoadhesive Nanovaccine Induces Humoral Immune Response of Red Tilapia (Oreochromis sp.) against Flavobacterium columnare Challenge

Cited by 21 publications

References 47 publications

Tilapia lake virus disease: Vaccine strategies to control the threat to tilapia aquaculture

Tilapia lake virus disease: Vaccine strategies to control the threat to tilapia aquaculture

Tilapia aquaculture, emerging diseases, and the roles of the skin microbiomes in health and disease

Strategies to enhance tilapia immunity to improve their health in aquaculture

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