Immersion in antibiotic solution prevents bacterial adhesion onto biodegradable prostatic stents

Abstract

Objective To determine whether immersion in antibiotic solution reduces or prevents bacterial adhesion onto biodegradable prostatic stents. Materials and methods Pre‐cut segments of polyglycolic acid (PGA) and polylactic acid (PLA) prostatic stents were incubated with two common uropathogenic bacterial strains (Enterococcus faecalis and Escherichia coli) with and without previous immersion in antibiotic solution. Tobramycin, ceftriaxone and ciprofloxacin solutions were used, as these antibiotics are commonly administered for the prophylaxis and treatment of urinary tract infection (UTI). Results Immersion in ciprofloxacin solution prevented the adherence of both bacterial strains. Immersion in ceftriaxone solution prevented only the adherence of the E. coli strain. Immersion in tobramycin solution had no effect on either of the strains. The stent materials per se did not influence bacterial adhesion. After immersion in ciprofloxacin, the stent segments retained significant antibacterial activity even after one day's incubation in saline. Conclusion Immersion in a suitable antibiotic solution may significantly reduce and even prevent bacterial adhesion onto biodegradable prostatic stents. Preventing bacterial adhesion may reduce the risk of UTI during the use of these devices.

Ex Vivo Strength Comparison of Bioabsorbable Tendon Plates and Bioabsorbable Suture in a 3‐Loop Pulley Pattern for Repair of Transected Flexor Tendons from Horse Cadavers

“…As with any implant, the plate could become a nidus of infection, especially in a contaminated wound, however, polylactic acid is reported to have some antibacterial properties 20 . PLA has also been shown to have antibiotic carrier properties in drug targeting and delivery systems and in preventing bacterial adhesion to bioabsorbable prostheses and stainless steel implants 21–26 …”

“…20 PLA has also been shown to have antibiotic carrier properties in drug targeting and delivery systems and in preventing bacterial adhesion to bioabsorbable prostheses and stainless steel implants. [21][22][23][24][25][26] Adhesions and loss of the gliding motions of the tendon may limit use of the plated tenorrhaphy. The plate is limited to the mid-metacarpal region and its size and shape may interfere with the gliding ability of the tendon.…”

Rose Petal Mimetic Surfaces with Antibacterial Properties Produced Using Nanoimprint Lithography

“…Bacterial adherence and growth on surfaces such as medical devices, sutures, protective clothing in hospitals, and food packaging and storage materials are common causes of concern, as they lead to the development of bacterial infections. − Coating these surfaces with some antibacterial materials can inhibit bacterial attachment and inhibit the spread of bacterial infections. − The most common antibacterial approach is the use of antibiotics. − However, the growing issue associated with the evolution of antibiotic-resistant bacteria has led to an increased interest among the scientific community to develop alternative approaches to prevent bacterial infections and the spread of infectious diseases. − Several strategies have been suggested in the literature for preventing bacterial adhesion and killing adhering bacteria. − Coating the material with antimicrobial chemical agents achieves protection against the bacteria by gradually releasing agents that kill the contacting bacteria. , However, this method loses its efficiency with time and poses a threat of developing resistant strains of bacteria.…”

Bacterial adherence to ofloxacin‐blended polylactone‐coated self‐reinforced l‐lactic acid polymer urological stents

“…Cormio et al [13] showed that immersion in suitable antibiotic solution prevented bacterial adhesion onto bioabsorbable stents. However, Reid et al.…”

“…Cormio et al [13] showed that immersion in suitable antibiotic solution prevented bacterial adhesion onto bioabsorbable stents. However, Reid et al [14] could not prevent bacterial bio®lm formation on the surface of ureteric stents after ESWL, despite antimicrobial prophylaxis and therapy.…”