Immediate type hypersensitivity and late phase reaction occurred consecutively in a patient receiving ethambutol and levofloxacin

Kato, Yukihiko; Sato, Yu; Nakasu, Miho; Tsuboi, Ryoji

doi:10.1186/s13223-018-0237-x

Cited by 7 publications

(3 citation statements)

References 9 publications

(10 reference statements)

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“…In this report, intradermal skin tests were performed; an immediate drug reaction was experienced with ethambutol within one hour, and a flare reaction occurred at the levofloxacin injection site 15 min after the test was administered and disappeared six hours later. The findings of this case suggest that drug eruptions are not necessarily caused by a single agent, and that multiple types of allergic reaction may occur consecutively in a single case [44].…”

Section: Cross-reactivity Of Quinolonesmentioning

confidence: 99%

Quinolone Allergy

et al. 2019

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Quinolones are the second most common antibiotic class associated with drug-induced allergic reactions, but data on quinolone allergy are scarce. This review article discusses the available evidence on quinolone allergy, including prevalence, risk factors, diagnosis, clinical manifestations, cross-reactivity, and management of allergic reactions. Although the incidence of quinolone allergy is still lower than beta-lactams, it has been increasingly reported in recent decades, most likely from its expanded use and the introduction of moxifloxacin. Thorough patient history remains essential in the evaluation of quinolone allergy. Many diagnostic tools have been investigated, but skin tests can yield false-positive results and in vitro tests have not been validated. The drug provocation test is considered the test of choice to confirm a quinolone allergy but is not without risk. Evidence regarding cross-reactivity among the quinolones is limited and conflicting. Quinolone allergy can be manifested either as an immediate or delayed reaction, but is not uniform across the class, with moxifloxacin posing the highest risk of anaphylaxis. Quinolone should be discontinued when an allergic reaction occurs and avoided in future scenarios, but desensitization may be warranted if no alternatives are available.

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Section: Cross-reactivity Of Quinolonesmentioning

confidence: 99%

Quinolone Allergy

et al. 2019

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“…6 Skin rash is the second leading adverse reaction and drug eruptions resulting from these medications are still a major obstacle to treatment. 5,7 Here, we present a mortality case induced by anti-TB side effect.…”

Section: Introductionmentioning

confidence: 97%

Steven-Johnson Syndrome associated with anti-tuberculosis drugs: a case reports

Pramita¹,

Pemayun²

2020

Intisari Sains Medis

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Introduction: Steven-Johnson syndrome (SJS) is an acute reaction to the skin and mucous membranes that is characterised by damage and flaking of the skin, accompanied by pain and can cause death. Treatment with anti-TB drugs sometimes results in side effects including SJS Â as one of the skin rash reaction and liver dysfunction. Steven-Johnson syndrome incidence and mortality due to anti-TB is quite rate and here we present a case with SJS and some other drugs side effect symptoms who passed away on the ninth day of treatment.Â Case description: A 53-year-old woman admitted to our emergency department with dyspnea, fatigue, erosion on oral mucosa, and erythema appears in the whole body accompanied by itch since two weeks ago, she also has yellowish sclera. She is in ongoing therapy of anti-tuberculosis drugs. History of hepatitis B, on admission there was marked elevation of leukocyte and liver function test (AST and ALT). Systemic corticosteroid was given as characterised therapy with topical steroid and antibiotics regimen for maculopapular rash.Conclusion: SJS is an emergency requiring high attention and intensive care evaluation with administration of intravenous systemic steroids as primary immunosuppressive therapy.

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“…Patients may experience side effects from anti-TB medication use, including as allergic and non-allergic drug reactions [6]. Skin rash is the second most common adverse event, and drug eruptions brought on by these drugs continue to be a significant treatment barrier [7,8]. Antitubercular medicines were used in 8 (13%) of the 60 instances with thiacetazone alone.…”

Section: Introductionmentioning

confidence: 99%

"A Rare Case of Stevens-Johnson Syndrome Associated with Anti-Tuberculosis Drugs"

Aran

2023

BJSTR

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Stevens-Johnson syndrome (SJS) is a severe allergic reaction to the skin and mucous membranes that causes skin damage and cracking, is painful, and can be fatal. Patients may experience side effects from anti-TB medication use, including as allergic and non-allergic drug reactions. Antitubercular medicines are a prominent source of toxic epidermal necrolysis (TEN) and SJS in underdeveloped nations such as India and Thailand. The majority of cases appear to be caused by thiacetazone. On 3 September 2022 patient was admitted in ICU Bed no. 8. and patient chief complaint of lesions over whole body since1 month also, chief complaint in swallowing for 15 days. Patient was diagnosed anti-tuberculosis drug induce Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) with sepsis.

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Immediate type hypersensitivity and late phase reaction occurred consecutively in a patient receiving ethambutol and levofloxacin

Cited by 7 publications

References 9 publications

Quinolone Allergy

Quinolone Allergy

Steven-Johnson Syndrome associated with anti-tuberculosis drugs: a case reports

"A Rare Case of Stevens-Johnson Syndrome Associated with Anti-Tuberculosis Drugs"

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