Immediate resection of positive margins improves local control in oral tongue cancer

Zhang, Lisa; Judd, Ryan T.; Zhao, Songzhu; Rygalski, Chandler J.; Briody, Ashleigh; Swendseid, Brian; Blakaj, Dukagjin; Agrawal, Amit; Özer, Enver; Carrau, Ricardo L.; Teknos, Theodoros N.; VanKoevering, Kyle K.; Rocco, James W.; Old, Matthew; Seim, Nolan B.; Puram, Sidharth V.; Haring, Catherine T.; Kang, Stephen Y.

doi:10.1016/j.oraloncology.2023.106402

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…The challenge of executing precise SM revision remains 70 , 123 . Real-time intraoperative assessment technology may present an effective solution 124 . Moreover, the necessity of adjuvant therapy for patients undergoing revisionary surgery is another topic meriting further exploration 125 .…”

Section: Surgical Margins In Head and Neck Squamous Cell Carcinomamentioning

confidence: 99%

Surgical margins in head and neck squamous cell carcinoma: a narrative review

Chen,

Zhong,

Cao

et al. 2024

International Journal of Surgery

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Head and neck squamous cell carcinoma (HNSCC), a prevalent and frequently recurring malignancy, often necessitates surgical intervention. The surgical margin (SM) plays a pivotal role in determining the postoperative treatment strategy and prognostic evaluation of HNSCC. Nonetheless, the process of clinical appraisal and assessment of the SMs remains a complex and indeterminate endeavor, thereby leading to potential difficulties for surgeons in defining the extent of resection. In this regard, we undertake a comprehensive review of the suggested surgical distance in varying circumstances, diverse methods of margin evaluation, and the delicate balance that must be maintained between tissue resection and preservation in head and neck surgical procedures. This review is intended to provide surgeons with pragmatic guidance in selecting the most suitable resection techniques, and in improving patients’ quality of life by achieving optimal functional and aesthetic restoration.

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Section: Surgical Margins In Head and Neck Squamous Cell Carcinomamentioning

confidence: 99%

Surgical margins in head and neck squamous cell carcinoma: a narrative review

Chen,

Zhong,

Cao

et al. 2024

International Journal of Surgery

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“…For localized lesion removal, the most controversial issue lies in the extent of the surgical margins. Further immediate tissue resection enhances local control in patients with positive margins of the main specimen of oral tongue cancer, according to the ndings of Zhang et al(34). Young et al(35) study of 2215 patients showed that the risk ratio for margins < 5 mm was signi cantly higher than that for margins ≥ 5 mm.…”

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confidence: 99%

A retrospective analysis utilizing the SEER database to develop and validate a prognostic nomogram for middle-aged and older patients diagnosed with squamous cell carcinoma of the mobile tongue

Qi,

Lun,

et al. 2024

Preprint

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BACKGROUND: The overall survival (OS) of squamous cell carcinoma of the mobile tongue remains dismal. This research aimed to develop a predictive nomogram model capable of forecasting the impact of various factors on the OS of mobile tongue squamous cell carcinoma (MTSCC) in middle-aged and older patients. METHODS: The study population consisted of patients diagnosed with MTSCC between 2010 and 2015. These individuals were identified through the utilization of the Surveillance, Epidemiology, and End Results (SEER) database. Following this, at random, these people were separated into two sets: a training set and a validation set. Risk factors for OS in the training set were identified using univariate and multivariate COX regression analyses. Prognostic nomograms for middle-aged and older patients with MTSCC were then created using independent risk factors and validated using the area under the ROC curve, calibration curves, and DCA curves. Finally, a comparison was made between the nomogram and TNM staging in order to assess their respective predictive capabilities. Results: In total, 2354 eligible patients were enrolled; of these, 707 were designated for validation, and 1647 were assigned to the training set. OS-independent prognostic factors included age, race, gender, tumor pathology grading, T-stage, N-stage, whether the primary site was operated on or not, and radiotherapy (all P < 0.05). The AUC values of the OS prognostic nomograms, which were built utilizing independent prognostic parameters, are as follows: The training set yielded an AUC of 0.793, 0.750, and 0.749 for the 1-year, 3-year, and 5-year OS, respectively. The calibration curves of the nomograms exhibited a substantial level of concordance between the projected and observed rates of survival. DCA curve concluded that prognostic net benefit was greater for nomograms featuring broad high-risk thresholds compared to TNM. CONCLUSION: This model has better predictive ability than AJCC staging and it can help oral and maxillofacial surgeons to predict the prognosis of tongue squamous carcinoma.

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Initial negative resection margin versus revised negative resection margin in patients who underwent surgery without adjuvant therapy for early-stage oral tongue squamous cell carcinoma

Kim,

Kim

et al. 2024

Oral Oncology

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Immediate resection of positive margins improves local control in oral tongue cancer

Cited by 5 publications

References 30 publications

Surgical margins in head and neck squamous cell carcinoma: a narrative review

Surgical margins in head and neck squamous cell carcinoma: a narrative review

A retrospective analysis utilizing the SEER database to develop and validate a prognostic nomogram for middle-aged and older patients diagnosed with squamous cell carcinoma of the mobile tongue

Initial negative resection margin versus revised negative resection margin in patients who underwent surgery without adjuvant therapy for early-stage oral tongue squamous cell carcinoma

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