Immediate Release Tablets:- A Review

Dhiman, Neha

doi:10.20959/wjpps20174-8921

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Immediate release (IR) dosage forms are still popular due to economic and pharmacokinetic reasons. It may improve compliance, solubility, stability, bioavailability, allows high drug loading, costeffective, adaptable, and amenable to existing processing and packaging machinery, and decreased disintegration and dissolution times (Neha, 2017). Superdisintegrant is important in IR dosage form, and developing novel material that can be used as an excipient is vital in formulation development, which could potentially solve the problem of material scarcity, patient and regulatory compliance.…”

Section: Pagtalunan Et Almentioning

confidence: 99%

Application of hydroxypropylated crosslinked starch from the grains of Oryza sativa L. as potential disintegrant in compressed solid dosage form

Pagtalunan¹,

Ramos²,

Guzman³

2022

J Pharm Pharmacogn Res

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Context: The modification of starch from the grains of NSICRc222 rice variety may provide a new material with enhanced disintegrating functionality in compressed solid dosage forms. Aims: To synthesize hydroxypropylated crosslinked rice starch that may possess characteristics of a good disintegrant. Methods: Starch was isolated by the wet milling method. The crosslinking was performed using trisodium trimetaphosphate as crosslinking agent, and successively hydroxypropylated by using phosphorous oxychloride. The evidences of chemical modifications were determined by FTIR, TGA, and DSC. The application of modified rice starch as a disintegrant was evaluated by determining the dissolution profile, and was compared to the performance of commercially available disintegrants. The compatibility of modified rice starch was employed using FTIR, and the stability of the formulation was subjected to an accelerated stability study. Results: The changes in infrared spectra and thermogram confirmed successful chemical modification of rice starch. Allopurinol and modified starch mixture staged from 0 to 3 months showed no significant changes in the infrared spectra, which suggest compatibility of HCR with allopurinol. The dissolution rate of allopurinol tablets at pH 1.2, pH 4.5, and pH 6.8 with various superdisintegrants were comparable to the dissolution rate that utilized hydroxypropylated crosslinked rice starch as disintegrant. The accelerated stability study showed no significant changes from 0th to 3rd month, and no degradation products were detected in the HPLC analysis. Conclusions: The chemical modification of rice starch through crosslinking and hydroxypropylation yielded a novel material comparable to the commercially available superdisintegrants.

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Section: Pagtalunan Et Almentioning

confidence: 99%

Application of hydroxypropylated crosslinked starch from the grains of Oryza sativa L. as potential disintegrant in compressed solid dosage form

Pagtalunan¹,

Ramos²,

Guzman³

2022

J Pharm Pharmacogn Res

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“…Immediate release may be provided by way of an appropriate pharmaceutically acceptable diluent or carrier, which diluent or carrier does not prolong to an appreciable extent, the rate of drug release and/or absorption. This term excludes formulations which are adapted to provide for "modified", "controlled", "sustained", "prolonged", "extended" or "delayed" release of drug [5,6].…”

Section: Introductionmentioning

confidence: 99%

Formulation and in vitro characterization of tapentadol HCL as immediate release tablets

Kumar¹,

Priyanka²,

Sindhu³

et al. 2018

GSC Biol. and Pharm. Sci.

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The aim of the present study is to develop and evaluate the immediate release tablet of tapentadol by direct compression method. The superdisintegrant explotab, solutab and polyplasdoneXL were used for immediate release of drug from tablet. The prepared tablets were evaluated for all pre-compression parameters and post-compression parameters. The drug-excipients interaction was investigated by FTIR. All formulation showed compliances with Pharmacopoeial standards. The study reveals that formulations prepared by direct compression F2 exhibits highest dissolution using explotab showed faster drug release 95.48 % over the period of 45 min while disintegration time of the tablet was showed 12 sec in comparison to other formulations of tapentadol.

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Immediate Release Tablets:- A Review

Cited by 2 publications

References 9 publications

Application of hydroxypropylated crosslinked starch from the grains of Oryza sativa L. as potential disintegrant in compressed solid dosage form

Application of hydroxypropylated crosslinked starch from the grains of Oryza sativa L. as potential disintegrant in compressed solid dosage form

Formulation and in vitro characterization of tapentadol HCL as immediate release tablets

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