Immediate Postoperative Low Platelet Count is Associated With Delayed Liver Function Recovery After Partial Liver Resection

Alkozai, Edris M.; Nijsten, Maarten; Jong, Koert P. de; Boer, Marieke T. de; Peeters, Paul; Slooff, Maarten J. H.; Porte, Robert J.; Lisman, Ton

doi:10.1097/sla.0b013e3181b76557

Cited by 113 publications

(126 citation statements)

References 27 publications

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“…Murata et al reported that platelets promote liver regeneration in the early period in a murine model [46]. Furthermore, Alkozai et al reported that a low platelet count immediately after partial hepatectomy was associated with delayed recovery of liver function [47]. Based on these results, platelet count appears to be a sensitive marker with respect to liver regeneration or functional recovery after liver stress or injury.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Hepatic Functional Parameters with Changes of Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization: A Follow-Up Report

Nanashima¹,

Tobinaga²,

Abo³

et al. 2010

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Relationship of Hepatic Functional Parameters with Changes of Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization: A Follow-Up Report

Nanashima¹,

Tobinaga²,

Abo³

et al. 2010

Journal of Surgical Research

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“…), was used according to the recommendations of the International Federation of Clinical Chemistry (IFCC). 3,4 For statistical analyses, mouse models were summarized as toxic/chemically induced (4-and 7-days LCA-fed, and 1-, 4-, and 8-weeks DDCfed mice), genetically induced (8-weeks-and 4-months-old…”

Section: Serum Alkaline Phosphatase Levels Accurately Reflect Cholestmentioning

confidence: 99%

Serum alkaline phosphatase levels accurately reflect cholestasis in mice

et al. 2015

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HCC lesions 5 cm in diameter.3 Based on the above data, we feel it is reasonable to utilize HCC lesions 4 cm as the key inclusion criteria for our study for both RFA and cryoablation (CRYO).For patients with tumor diameters of 3.1 to 4.0 cm, the 1-, 3-, and 5-year tumor-free survival (TFS) rates were 86%, 51%, and 29% in the CRYO group and 84%, 49%, and 30% in the RFA group, respectively. There was no significant difference between these two groups (P 5 0.88). Consistent with other studies, 2 we did not find that tumor size would significantly affect overall survival (OS) and TFS. But there was a significantly lower local tumor progression (LTP) rate in the CRYO group, compared to that in the RFA group (7 of 91 [7.7%] HCC lesions for cryoablation versus 14 of 77 [18.2%] for RFA, P 5 0.041).Regarding the effect of the alternative treatment for those with distant tumor recurrence (110 patients) on OS, Prof. Hyun is correct, in that combination therapy using transarterial chemoembolization (TACE), sorafenib, and local ablation could benefit the OS. Considering OS was influenced by many factors, we chose OS and TFS as the secondary endpoints. We did not collect more detailed information, such as the frequency of TACE or local ablation times, duration of sorafenib treatment, and time for conservative management. So, we did not analyze the effect of retreatments of HCC recurrence and metastasis on OS.It should be noted that at the time this study was designed, the greatest concern was the procedure-related complications. Thus, it is important to systemically assess the safety of cryoablation through a randomized, controlled trial (RCT) with comparison to RFA. It is also important to evaluate the efficacy of cryoablation for HCC by a RCT, and the LTP has been a standard measure of the primary endpoints. Our study has demonstrated that percutaneous cryoablation is safe and effective and should be one of the standard ablation modalities for HCC.

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“…Various animal experiments in pigs, mice and rats confirmed the promotive effect of platelets after hepatectomy [14]. Delayed liver function after liver surgery for colorectal metastases in non-cirrhotic patients with postoperative low platelet counts has been described [15].…”

Section: Introductionmentioning

confidence: 92%

Low Postoperative Platelet Count is Associated with Higher Morbidity after Liver Surgery for Colorectal Metastase

Riediger¹

2014

J Liver

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Immediate Postoperative Low Platelet Count is Associated With Delayed Liver Function Recovery After Partial Liver Resection

Cited by 113 publications

References 27 publications

Relationship of Hepatic Functional Parameters with Changes of Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization: A Follow-Up Report

Relationship of Hepatic Functional Parameters with Changes of Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization: A Follow-Up Report

Serum alkaline phosphatase levels accurately reflect cholestasis in mice

Low Postoperative Platelet Count is Associated with Higher Morbidity after Liver Surgery for Colorectal Metastase

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