Immediate Improvement in Penile Hemodynamics after Cessation of Smoking: Previous Results

Sighinolfi, Maria Chiara; Mofferdin, A.; Stefani, S. De; Micali, Salvatore; Cicero, Arrigo F G; Bianchi, G

doi:10.1016/j.urology.2006.09.026

Cited by 40 publications

(29 citation statements)

References 16 publications

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“…Other risk factors, such as dyslipidemia and hyperhomocysteinemia, were not evaluated because screening for these conditions was not uniform within our patient cohort. There has been some suggestion that actively addressing cardiovascular risk factors by initiating preventive measures such as a smoking cessation program35,36 or a weight-loss regimen,37 by treating hypertension,38 and by controlling blood glucose levels may contribute to reducing the risk of ED. Therefore, actively addressing common cardiovascular risk factors may provide both a cardiovascular and a sexual benefit.…”

Section: Discussionmentioning

confidence: 99%

A Population-Based, Longitudinal Study of Erectile Dysfunction and Future Coronary Artery Disease

Inman

Sauver

Jacobson

et al. 2009

Mayo Clinic Proceedings

381

108

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OBJECTIVE To assess the association between erectile dysfunction (ED) and the long-term risk of coronary artery disease (CAD) and the role of age as a modifier of this association. PARTICIPANTS AND METHODS From January 1, 1996, to December 31, 2005, we biennially screened a random sample of 1402 community-dwelling men with regular sexual partners and without known CAD for the presence of ED. Incidence densities of CAD were calculated after age stratification and adjusted for potential confounders by time-dependent Cox proportional hazards models. RESULTS The prevalence of ED was 2% for men aged 40 to 49 years, 6% for men aged 50 to 59 years, 17% for men aged 60 to 69 years, and 39% for men aged 70 years or older. The CAD incidence densities per 1000 person-years for men without ED in each age group were 0.94 (40-49 years), 5.09 (50-59 years), 10.72 (60-69 years), and 23.30 (≥70 years). For men with ED, the incidence densities of CAD for each age group were 48.52 (40-49 years), 27.15 (50-59 years), 23.97 (60-69 years), and 29.63 (≥70 years). CONCLUSION ED and CAD may be differing manifestations of a common underlying vascular pathology. When ED occurs in a younger man, it is associated with a marked increase in the risk of future cardiac events, whereas in older men, ED appears to be of little prognostic importance. Young men with ED may be ideal candidates for cardiovascular risk factor screening and medical intervention.

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Section: Discussionmentioning

confidence: 99%

A Population-Based, Longitudinal Study of Erectile Dysfunction and Future Coronary Artery Disease

Inman

Sauver

Jacobson

et al. 2009

Mayo Clinic Proceedings

381

108

View full text Add to dashboard Cite

show abstract

“…Though some studies suggest that smoking cessation, hypertension management (especially with angiotensin receptor blockers), management of lipids and physical activity programs may improve ED, there is some controversy regarding this concept. [28][29][30][31][32][33][34] One problem is that by the time ED develops in midlife it may be too late to fully reverse the vascular damage that has caused the ED. 28 There also have been suggestions that risk factor modification may improve the response of men with ED to PDE 5 inhibitors.…”

Section: Risk Factor Modification In Men With Edmentioning

confidence: 99%

Erectile dysfunction as a predictor of cardiovascular disease

Kloner

2008

Int J Impot Res

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Although it has been recognized that erectile dysfunction (ED) and coronary artery disease share many of the same risk factors-smoking, dyslipidemia, diabetes and hypertension-just in the past few years several new studies now suggest that ED is an important early marker of the presence of coronary artery disease. Recent analyses suggest that ED symptoms occur prior to coronary artery disease symptoms and may be a predictor of future major cardiovascular events. Some of these new studies also suggest that ED is an independent risk factor for predicting cardiovascular events-that is independent of other well-established risk factors. Taken together, these new studies suggest that when a patient presents with ED, the patient should be questioned about cardiac health and cardiovascular risk factors. If cardiovascular risk factors are identified, they should be worked up and aggressively treated-as treatment of these risk factors may be life-saving.

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“…Patterns of ED in former smokers suggest that there may be a latent interval between active smoking and symptomatic ED, involving a process initially triggered by smoking: in fact, odds of ED in former smokers were significantly higher 6-10 years following cessation of smoking than <6 or >10 years (Chew et al, 2009). Another study in 40 smokers with ED undergoing penile colour Duplex ultrasound at baseline and after 24-36 h after smoking cessation demonstrated a significant improvement in end-diastolic velocity and a trend towards an increase in peak systolic velocity trough the penile artery (Sighinolfi et al, 2007), confirming the short term detrimental effects of smoking.…”

Section: Correction Of Risk Factorsmentioning

confidence: 99%

Erectile dysfunction in heart failure patients: a critical reappraisal

et al. 2013

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SUMMARYHeart failure (HF) is a complex clinical syndrome with a constantly increasing incidence and prevalence in western countries. Total absence of sexual activity is registered in 30% of HF patients. Moreover, HF-induced reduction in exercise tolerance, side effects of HF medications and the coexistence of shared risk factors between HF and sexual dysfunction may further aggravate the sexual health of HF patients. The purpose of this review is to examine the pathophysiological mechanisms behind the association of erectile dysfunction (ED) and HF, the potential therapeutic approaches and the eventual indications for sexual activity in HF patients. Medline and Cochrane Library search was performed from January 1970 through October 2012 to retrieve relevant papers outlining the association between ED and HF. Many evidences have outlined a tight association between ED and HF pathophysiological standpoint. Shared risk factors, common pathogenic traits and epidemiologic association represent some of the links between these conditions. Erectile dysfunction has been recognized as an earlier predictor of cardiovascular events; moreover, HF itself may cause and/ or worsen ED because of its particular feature and co-morbidities. Furthermore, some cardiovascular drugs may contribute to impaired erectile function. In stable patients with stable HF, sexual activity is generally not contraindicated but it should be encouraged, as a form of moderate-intensity physical exertion. An effective treatment of ED in HF patients should be founded on the correction of reversible risk factors, on the choice of cardiovascular drugs with the lowest effect upon patient's erectile function, and on the use of phosphodiesterase-5-inhibitors. Physicians should be aware of the close relation between HF and ED and of the related clinical and therapeutic implications, in order to improve patients quality of life and clinical outcome.

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Immediate Improvement in Penile Hemodynamics after Cessation of Smoking: Previous Results

Cited by 40 publications

References 16 publications

A Population-Based, Longitudinal Study of Erectile Dysfunction and Future Coronary Artery Disease

A Population-Based, Longitudinal Study of Erectile Dysfunction and Future Coronary Artery Disease

Erectile dysfunction as a predictor of cardiovascular disease

Erectile dysfunction in heart failure patients: a critical reappraisal

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