Immediate loading seems to be a relatively safe procedure. From the prosthodontic point of view, there are specific guidelines to follow. They are: implants should be splinted with a metallic bar and acrylic interim prostheses until full osseointegration occurs. To have a successful outcome, screw-retained interim prostheses are recommended. CAD/CAM systems can improve the placement of implants with minimum risk. Regarding occlusion, there is a disagreement on when and how to provide occlusal contacts, but all authors agree on keeping centric contacts only. Finally, concerning the number of implants required for an immediate overdenture, no conclusive evidence could be found.