Immediate effects of the serotonin antagonist granisetron on temporomandibular joint pain in patients with systemic inflammatory disorders

Effects of Grape Seed Proanthocyanidin on 5-Hydroxytryptamine3 Receptors in NCB-20 Neuroblastoma Cells

“…The results of several studies have shown that proanthocyanidin has antinociceptive and antiemetic actions although the precise mechanism is unclear. 11,13,16) On the other hand, the 5-HT 3 receptors mediate emesis and pain, 27,28) and some antagonists of the 5-HT 3 receptors, like ondansetron, have been shown to prevent the development of pain and emesis. [29][30][31][32] In addition, some antiemetic drugs like metoclopramide have been reported to be potent antagonists of 5-HT 3 receptors.…”

Temporomandibular joint injection with corticosteroid and local anesthetic for limited mouth opening

“…Studies of TMJ injections have focused on decreased pain after injection in patients with both pain and limited mouth opening secondary to inflammatory disorders of the joint, such as arthritis and capsulitis (9)(10)(11)(12)(13)(14)(15)(16). One study focused on improvement in mouth opening after TMJ injection with hyaluronic acid in patients with DDWOR (17).…”

Temporomandibular Joint Arthroscopy

“…The answer is, that during this procedure several inflammatory mediators available in the synovial fluid as prostaglandins (K.I. Murakami et al, 1998), cytokines (Kardel et al, 2003;Voog et al, 2003b), serotonin as pain mediator (Voog et al, 2000) etc. are washed out.…”

“…Serotonin, mediator of pain and inflammation, is produced in the enterocromaffin cells of the gastrointestinal mucosa and absorbed by platelets. It is produced also in the synovial membrane and is present in the synovial fluid and in blood in case of rheumatoid arthritis and is involved in the mediation of TMJ pain in systemic inflammatory joint diseases (Alstergren & Kopp, 1997;Voog et al, 2000). It plays a role also in bone metabolism (Warden & Haney, 2008).…”