Immediate effect of irradiation on microvasculature

Radiation induces different changes in expression profiles of normal rectal tissue compared with rectal carcinoma

“…Previous reports have shown a decrease of tumor vascularization after radiation [9,15] using IHC. Furthermore, genes involved in the regulation of angiogenesis, such as trombospondin [5], interleukin-8 [14] and transforming growth factor (TGF) b [30] (Table 4) are differentially expressed in normal and tumor tissue.…”

The uptake of 3H-vincristine by a mouse carcinoma during a course of fractionated radiotherapy

“…It has been known for a long time that radiation has severe effects on blood flow and extravasation of macromolecules (Zanelli & Lucas, 1976;Song & Levitt, 1970) and has recently been confirmed by Krishnan et al, (1988) Whether the results of the present investigation apply to all drugs and all tumours, especially human tumours, is not known, and neither is the effect of different fractionation regimes. On the basis of the above discussion one would expect all drugs to behave at least qualitatively in a similar manner.…”

“…It is by now fairly well established that radiation has profound effects on vascular function in the irradiated tissue, resulting in alterations in blood flow (Zanelli & Lucas, 1976), in the structure of the capillary endothelium (Eddy, 1980) and in the extravasation of plasma macromolecules (Krishnan et al, 1988). Furthermore, there are indications that the vascular effects of radiation are not random but systematic, i.e.…”

An Ocular Photometric Method for Radiation Biodosimetry in Patients following Whole Body Irradiation

“…Our own analysis of the AH through mass-spectroscopy in irradiated nonhuman primates shows a dose-related change in proteins associated with inflammation, immunity, and redox fluctuations that are well-known markers of acute radiation responses [14][15]. Changes in protein composition in the AH may also reflect a drop in serum albumin as documented in experimental studies after WBI, perhaps related to early vascular leakage in multiple tissues [16][17][18] with an associated change in the composition of the AH.…”