Immediate Early Genes: Their Involvement in Physiological and Pathological Responses in the Nervous System

Hayward,; Morgan, Jacqueline

doi:10.1037/e496052006-005

Cited by 3 publications

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“…Recognizing that both D1 and D5 receptors are expressed in these nuclei, it is possible that D1 and D5 dopamine receptors act in concert or individually to transduce dopamine action in these nuclei. Because c-fos is a transcriptional activating factor (Hayward et al, 1993), our observations suggest that acute responses to D1 or D5 dopamine receptor activation involve responses at the gene transcription level. The SON and PVN play integral roles in maintaining water homeostasis through the secretion of vasopressin (Reppert and Schwartz, 1987).…”

Section: Discussionmentioning

confidence: 96%

Functional D1 and D5 dopamine receptors are expressed in the suprachiasmatic, supraoptic, and paraventricular nuclei of primates

Rivkees

Lachowicz

1997

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In rodents, D1 dopamine receptors are expressed in the suprachiasmatic nucleus and are believed to play important roles in regulating circadian rhythms. It is not currently known if the primate circadian system can be influenced by dopaminergic agents, which have broad clinical use. To determine if dopamine receptors can potentially influence primate circadian function, we examined the expression of D1 dopamine receptors in the anterior hypothalamus of ring-tailed macaques (Macaca nemestrema), baboons (Papto sp.), and humans. Because D5 dopamine receptors also stimulate adenylyl cyclase activity, D5 dopamine receptor expression was studied as well. We used [125I]SCH 23982, which binds to D1 and D5 dopamine receptors, and labeling of the suprachiasmatic (SCN), supraoptic (SON), and paraventricular (PVN) nuclei was detectable in each species. In situ hybridization studies revealed differential expression of D1 and D5 dopamine receptor mRNA in the hypothalamus. D1 dopamine receptor mRNA was expressed in the SCN, SON, and PVN. By contrast, D5 dopamine receptor mRNA was expressed only in the SON and PVN of baboons and humans. Injection of the D1/D5 dopamine receptor agonist SKF 38393 at night increased the uptake of 2-deoxy-D-[14C]glucose in the SCN, SON, and PVN of newborn baboons. By contrast, c-fos mRNA expression was induced in the SON and PVN, but not in the SCN. These data show that D1 and D5 dopamine receptors are present in the hypothalamus of primates and show that activation of these receptors acutely influences SCN, SON, and PVN activity.

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Section: Discussionmentioning

confidence: 96%

Functional D1 and D5 dopamine receptors are expressed in the suprachiasmatic, supraoptic, and paraventricular nuclei of primates

Rivkees

Lachowicz

1997

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Timing of c-jun protein induction in lumbar dorsal root ganglia after sciatic nerve transection varies with lesion distance

Kenney

Kocsis

1997

Brain Research

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Review : The Immediate-Early Gene Response and Neuronal Death and Regeneration

Morgan

Curran

1995

Neuroscientist

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The induction of the cellular immediate-early gene (cIEG) response is the earliest known transcriptional con sequence of neuronal excitation. It is believed that the products of the cIEGs (such as c- fos and c- jun) serve to bring about persistent changes in neuronal phenotype by altering gene expression and modifying signal transduction pathways. This has led, on the one hand, to the burgeoning use of Fos immunohistochemistry as a surrogate form of neuronal activity mapping and, on the other hand, to a quest for the biochemical functions of individual cIEG products in the nervous system. Recent studies of neuronal death and regen eration have contributed substantially to our vision of the molecular and biological characteristics of the cIEG response. Indeed, they have challenged some of its long-held tenets. Therefore, we will use these results to illustrate our most contemporary view of the cIEG response in the nervous system. The Neuroscientist 1:68- 75,1995

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Immediate Early Genes: Their Involvement in Physiological and Pathological Responses in the Nervous System

Cited by 3 publications

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Functional D1 and D5 dopamine receptors are expressed in the suprachiasmatic, supraoptic, and paraventricular nuclei of primates

Functional D1 and D5 dopamine receptors are expressed in the suprachiasmatic, supraoptic, and paraventricular nuclei of primates

Timing of c-jun protein induction in lumbar dorsal root ganglia after sciatic nerve transection varies with lesion distance

Review : The Immediate-Early Gene Response and Neuronal Death and Regeneration

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