Immediate early genes and brain DNA remodeling in the Naples High- and Low-excitability rat lines following exposure to a spatial novelty

Papa, Michèle; Pellicano, Massimiliano; Cerbone, A.; Lamberti-D'Mello, C.; Menna, T.; Buono, C.; Giuditta, Antonio; Welzl, Hans; Sadile, A.G.

doi:10.1016/0361-9230(94)00254-x

Cited by 27 publications

(8 citation statements)

References 21 publications

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“…However, the role of IEG expression has been extensively studied in the hippocampus, amygdala and cortex (for reviews, see Papa et al ., ; Zhu & Herbert, ; Cammarota et al ., ; Vann et al ., ; Guzowski, ) and it was hypothesised that the transient expression of IEGs after numerous behavioral tasks contributes to the modification of synaptic networks associated with learning and memory, an interpretation largely supported by experiments down‐regulating IEG expression by AS administration (Grimm et al ., ; He et al ., ; Countryman et al ., ; Yasoshima et al ., ; Doron & Rosenblum, ; Katche et al ., ).…”

Section: Discussionmentioning

confidence: 99%

c‐fos down‐regulation inhibits testosterone‐dependent male sexual behavior and the associated learning

Niessen

Balthazart

Ball

et al. 2013

Eur J of Neuroscience

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Environmental stimulation results in an increased expression of transcription factors called immediate early genes (IEG) in specific neuronal populations. In male Japanese quail, copulation with a female increases the expression of the IEGs zenk and c-fos in the medial preoptic nucleus (POM), a key nucleus controlling male sexual behavior. The functional significance of this increased IEG expression that follows performance of copulatory behavior is unknown. We addressed this question by repeatedly quantifying the performance of appetitive (learned social proximity response) and consummatory (actual copulation) sexual behavior in castrated, testosterone-treated males that received daily intracerebroventricular injection of an antisense oligodeoxynucleotide targeting c-fos or control vehicle. Daily antisense injections significantly inhibited expression of copulatory behavior as well as acquisition of the learned social proximity response. A strong reduction of the proximity response was still observed in antisense-treated birds that copulated with a female, ruling out the indirect effect of the absence of interactions with females on the learning process. After a two-day interruption of behavioral testing but not of antisense injections, birds were submitted to a final copulatory test that confirmed the behavioral inhibition in antisense-injected birds. Brains were collected 90 min after the behavioral testing for quantification of c-fos immunoreactive cells. A significant reduction of the number of c-fos-positive cells in POM but not in other brain regions was observed following antisense injection. Together, data suggest that c-fos expression in POM modulates copulatory behavior and sexual learning in male quail.

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Section: Discussionmentioning

confidence: 99%

c‐fos down‐regulation inhibits testosterone‐dependent male sexual behavior and the associated learning

Niessen

Balthazart

Ball

et al. 2013

Eur J of Neuroscience

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“…Induction of c-fos and/or zif268 RNA expression by behavioral training has been reported in a number of tasks, including two-way avoidance (Nikolaev et al, 1992), brightness discrimination (Tischmeyer et al, 1990;Grimm et al, 1997), an alternation task (Nagahara and Handa, 1995), and an odor discrimination task (Hess et al, 1995a,b). Additionally, a number of investigators have shown that c-Fos protein expression is increased in the hippocampus by behavioral training (Papa et al, 1995;Zhu et al, 1997;Wan et al, 1999;Cammarota et al, 2000;Vann et al, 2000). Recently, Hall et al (2000) reported increased BDNF gene expression following learning of contextual fear conditioning, and increased zif268 gene expression following retrieval of the same task (Hall et al, 2001).…”

Section: Correlative Studiesmentioning

confidence: 99%

Insights into immediate‐early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches

2002

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In the 14 years since it was discovered that specific genes could be dynamically regulated in the brain by neural activity, there has been a substantial research focus attempting to understand the role immediate-early genes (IEGs) play in various brain functions. This article examines the involvement of IEGs in hippocampal synaptic plasticity and in memory consolidation processes performed by the hippocampus. Studies employing conventional IEG detection methodologies and a novel gene-imaging approach that provides temporal and cellular resolution (cellular compartment analysis of emporal activity by fluorescence in situ hybridization or catFISH) provide evidence supporting the assertion that IEG expression reflects the integration of information processed by hippocampal neurons. However, IEG expression is not merely correlated with neural activity, but also plays a pivotal role in stabilizing recent changes in synaptic efficacy. As such, localized disruption of IEGs Arc or c-fos by intrahippocampal administration of antisense oligonucleotides or germline disruption of the IEGs c-fos, tissue plasminogen activator, or zif268 impairs consolidation of long-term memory formation, without affecting learning or short-term memory. Further investigation into the expression and function of IEGs using catFISH and antisense approaches will likely increase understanding of the molecular and cellular bases of information processing involving the hippocampus.

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“…The expression of IEGs, including c-Fos in particular, has been shown to be potentially induced in different limbic and cortical regions by exposure to novel stimuli. Furthermore, the degree of familiarity of the stimuli in¯uences the patterns of c-Fos activation into the brain, thus suggesting the existence of an habituation process towards such stimuli (Papa et al, 1993(Papa et al, , 1995Zhu et al, 1995Zhu et al, , 1997Montag-Sallaz et al, 1999).…”

Section: Patterns Of C-fos Immunoreactivity Following a Single Trainimentioning

confidence: 99%

Differential learning‐stage dependent patterns of c‐Fos protein expression in brain regions during the acquisition and memory consolidation of an operant task in mice

Bertaina-Anglade

Tramu

Destrade

2000

Eur J of Neuroscience

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The present study analysed the effects of the stage of learning of an appetitive operant conditioning task on the spatial and temporal patterns of c-Fos protein levels in the brain of BALB/c mice. c-Fos levels were assessed by immunohistochemistry at either 60, 120 or 180 min after either the first, the second or the fifth daily training session and compared to sham animals. The results show an increase of c-Fos-positive nuclei in several subcortical and cortical brain regions, 60-min post-acquisition. Because these activations were a function of task mastery, the data indicate that they were specifically related to learning. Following the first acquisition session, significant increases in c-Fos-positive neurons were observed in the dorsal hippocampus (CA3), anterior cingulate, occipital and parietal cortices. Following the second daily training session, c-Fos was highly expressed in some subcortical regions, the hippocampus, the subiculum, the entorhinal, and posterior cingulate areas. Moreover, a significant correlation was found between the progression of performance from day 1 to day 2 and c-Fos expression on the hippocampal CA1 subfield. Following complete acquisition, no further task-dependent increases in c-Fos-labelled nuclei was observed in any brain region sampled, suggesting that the intervention of c-Fos-induced mechanisms in the consolidation process were terminated. The training stage-dependent changes in regional post-training c-Fos expression in the hippocampus and the connected limbic regions suggest that this neuronal network is actively engaged in memory consolidation processes.

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Immediate early genes and brain DNA remodeling in the Naples High- and Low-excitability rat lines following exposure to a spatial novelty

Cited by 27 publications

References 21 publications

c‐fos down‐regulation inhibits testosterone‐dependent male sexual behavior and the associated learning

c‐fos down‐regulation inhibits testosterone‐dependent male sexual behavior and the associated learning

Insights into immediate‐early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches

Differential learning‐stage dependent patterns of c‐Fos protein expression in brain regions during the acquisition and memory consolidation of an operant task in mice

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