Immediate changes of the electroencephalograms after intravenous injection of clonazepam and their relation to its effect on clinical fits in children with minor seizures.

Iinuma, Kazuie; Tamahashi, Seiko; Otomo, Hiromi; Ônuma, Akira; Takamatsu, Norimitsu

doi:10.1620/tjem.125.223

Tohoku J. Exp. Med.

1978

DOI: 10.1620/tjem.125.223

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Immediate changes of the electroencephalograms after intravenous injection of clonazepam and their relation to its effect on clinical fits in children with minor seizures.

Kazuie Iinuma

Seiko Tamahashi

Hiromi Otomo

et al.

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1983

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Kinetics of Clonazepam in Relation to Electroencephalographic and Clinical Effects

Stahl¹,

Persson²,

Petters³

et al. 1983

Epilepsia

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The aim of this study was to see if the immediate EEG and clinical response to an intravenous dose of clonazepam was predictive for the effect of oral clonazepam maintenance therapy. Four children with petit mal epilepsy were given clonazepam intravenously during continuous EEG recording. Clonazepam plasma concentrations were determined repeatedly with a high performance liquid chromatographic method using a reversed phase system. The day after the intravenous dose the patients were given oral therapy with clonazepam. Repeated long-term EEG recordings were made and plasma concentrations of clonazepam were determined. There was no clinically satisfactory effect of clonazepam during oral maintenance treatment in three of the children who responded well to the intravenous dose of clonazepam. Thus, the immediate response to intravenous clonazepam was not a good predictor of the long-term effects in our patients.

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Kinetics of Clonazepam in Relation to Electroencephalographic and Clinical Effects

Stahl¹,

Persson²,

Petters³

et al. 1983

Epilepsia

View full text Add to dashboard Cite

show abstract

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Immediate changes of the electroencephalograms after intravenous injection of clonazepam and their relation to its effect on clinical fits in children with minor seizures.

Cited by 1 publication

References 16 publications

Kinetics of Clonazepam in Relation to Electroencephalographic and Clinical Effects

Kinetics of Clonazepam in Relation to Electroencephalographic and Clinical Effects

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