Immediate and delayed tolerance of iohexol and ioxaglate in lower limb phlebography: A double-blind comparative study in humans

Bertrand, P.; Delhommais, Anne; Alison, D.; Rouleau, P

doi:10.1016/s1076-6332(05)80436-2

Cited by 12 publications

(4 citation statements)

References 13 publications

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“…An intensely pruritic, burning sensation on the cheeks and jaw (1) was followed by an eruption progressing to the upper extremities and chest (2) , abdomen and sides (3) , lower extremities (4) , and fi nally the back (not shown). While initially, intertriginous areas were involved and the palms and soles (5) were spared, by 72 hours, the latter parts became involved, along with generalized xerosis, as well as pustules on a nonerythematous base scattered on the upper trunk and proximal upper extremities (6) .…”

Section: Figurementioning

confidence: 99%

Delayed Adverse Reaction to Contrast-enhanced CT: A Prospective Single-Center Study Comparison to Control Group without Enhancement

Loh

Bagheri

Katzberg³

et al. 2010

Radiology

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Section: Figurementioning

confidence: 99%

Delayed Adverse Reaction to Contrast-enhanced CT: A Prospective Single-Center Study Comparison to Control Group without Enhancement

Loh

Bagheri

Katzberg³

et al. 2010

Radiology

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“…There is an important variability among rates of delayed reactions from one study to another [39][40][41][42][43] (Table IV). In one Japanese study, delayed reactions were noted in 12.4% of 2370 patients who underwent CT.…”

Section: Frequencymentioning

confidence: 99%

“…Delayed reactions have been reported with all categories of CM [39][40][41][42][43][44][45][46][47]. Interestingly, unlike acute reactions, there is no significant difference in the incidence of delayed reactions between ionic and non-ionic CM (Table IV), nor between the different non-ionic monomers [47].…”

Section: Categories Of Contrast Medium Involvedmentioning

confidence: 99%

Allergy‐like reactions to iodinated contrast agents. A critical analysis

Idée

Pinès

Prigent

et al. 2005

Fundamemntal Clinical Pharma

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Allergy-like reactions may occur following administration of iodinated contrast media (CM), mostly in at-risk patients (patients with history of previous reaction, history of allergy, co-treated with interleukin-2 or beta-blockers, etc.) but remain generally unpredictable. Severe and fatal reactions are very rare events. All categories of CM may induce such reactions, although first generation (high osmolar CM) have been found to induce a higher rate of adverse events than low osmolar CM. However, no differences were found between the two categories of CM with respect to mortality. Delayed reactions can also occur. There are no differences between the various categories of CM except for non-ionic dimers, which are more likely to induce such effect. Numerous clinical studies have evaluated the prophylactic value of drugs (mostly antihistamines and corticosteroids). Results are unclear and highly variable. Any prevention depends upon the mechanism involved. However, the mechanism of CM-induced allergy-like reaction remains disputed. Relatively recent data revived the hypothesis of a type-I hypersensitivity mechanism. Positive skin tests to CM have been reported. However, the affinity of IgE towards CM has been found to be very low in the only study which actually evaluated it. Other pathophysiological mechanisms (involving direct secretory effects on mast cells or basophils, or activation of the complement system associated or not with the plasma contact system) are also much debated. Anaphylaxis and anaphylactoid reactions are, in the end, clinically undistinguishable.

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“…There do not appear to be significant differences in the incidence of late reactions between ionic and non-ionic agents [1,24,32,33], nor between the different non-ionic monomers [1,24,33]. No significant differences have been found between the non-ionic monomers and the ionic dimer ioxaglate, either [27,34,35].…”

Section: Frequencymentioning

confidence: 99%

Late adverse reactions to intravascular iodinated contrast media

et al. 2003

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Late adverse reactions to intravascular iodinated contrast media are defined as reactions occurring 1 h to 1 week after contrast medium injection. They have received increasing interest over the past decade, but their prevalence remains uncertain and their pathophysiology is not fully understood. The Contrast Media Safety Committee of the European Society of Urogenital Radiology decided to review the literature and to issue guidelines. An extensive literature search was carried out and summarized in a report. Based on the available information, simple guidelines have been drawn up. The report and guidelines were discussed at the 8th European Symposium on Urogenital Radiology in Genoa. Late adverse reactions after intravascular iodinated contrast medium include symptoms such as nausea, vomiting, headache, itching, skin rash, musculoskeletal pain, and fever. A significant proportion of these reactions is unrelated to the contrast medium; however, allergy-like skin reactions are well-documented side effects of contrast media with an incidence of approximately 2%. Late reactions appear to be commoner after nonionic dimers. The majority of late skin reactions after contrast medium exposure are probably T-cell-mediated allergic reactions. Patients at increased risk of late skin reactions are those with a history of previous contrast medium reaction and those on interleukin-2 treatment. Most skin reactions are self-limiting and resolve within a week. Management is symptomatic and similar to the management of other drug-induced skin reactions.

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Immediate and delayed tolerance of iohexol and ioxaglate in lower limb phlebography: A double-blind comparative study in humans

Cited by 12 publications

References 13 publications

Delayed Adverse Reaction to Contrast-enhanced CT: A Prospective Single-Center Study Comparison to Control Group without Enhancement

Delayed Adverse Reaction to Contrast-enhanced CT: A Prospective Single-Center Study Comparison to Control Group without Enhancement

Allergy‐like reactions to iodinated contrast agents. A critical analysis

Late adverse reactions to intravascular iodinated contrast media

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