Immediate and Delayed Effects of an Enzyme-dependent Mineralizing Mouthrinse on Dental Plaque

Schamschula, R. G.; Pearce, E.I.F.; Un, Pauline S. H.; Cooper, Michael H.

doi:10.1177/00220345850640031301

Cited by 7 publications

(3 citation statements)

References 13 publications

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“…Ashley and Wilson 18) reported that there were significant positive correlations between Ca and P concentrations in saliva and those in dental plaque. Similar results were obtained by Pearce 19) and Schamschula et al 20) Cury et al 21) reported that correlations between Ca and P (r=0.87, P=0.0001) were found in 2-day dental plaque. The Ca/P ratios of 4-day plaque in our previous study showed 0.40-0.99.…”

Section: Discussionsupporting

confidence: 84%

Site-specificity of mineral ions in 2-day dental plaque obtained from children and young adults

Hirose

Fukuda

Yahata

et al. 2010

Pediatric Dental Journal

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The aim of this study was to determine the variation in mineral ions (Ca and P) concentrations in 2-day dental plaque taken from different areas of the deciduous and the permanent dentition that may be related to the caries status of tooth surfaces obtained from children and young adults. We also compared those minerals between the deciduous and the permanent dentition. Plaque samples were collected from eight dentition sites, including the upper-anterior-buccal (UAB) and-lingual (UAL), lower-anterior-buccal (LAB) and-lingual (LAL), upper-posterior-buccal (UPB) and-lingual (UPL), lower-posterior-buccal (LPB) and-lingual (LPL) regions. Significant differences among these eight different sites were determined from Ca and P ions concentrations, as well as the Ca/P ratio, calculated by ANOVA. Plaque associated with the LAL region closest to the main salivary ducts and that is less prone to caries, had significantly higher levels of Ca, P ions concentrations, a higher Ca/P ratio than any other dentition areas in both children and young adult subjects. Statistical differences were seen in minerals between children and young adults. Ca ion concentrations in dental plaque from young adults were significantly higher than those of children at the LAL site. Statistical analysis of the relationships between Ca and P ions showed that there were strong associations between Ca and P ions, especially in the UPB, LAL and LPL regions where there is a high exposure to saliva. We conclude that there is a site-specificity of plaque mineral content in both children and young adults, which may reflect the differences in exposure to saliva, resulting in differences in the local cariostatic challenge. tooth surface such as saliva or dental plaque fluid. Importantly, the DS of plaque fluid is directly related to not only pH but also Ca and P ions concentrations which are common ion constituents of enamel hydroxyapatite 1). The release of these ions into the plaque-fluid phase, following bacterial acid production, can reduce the driving force for demineralization by increasing DS of plaque fluid with respect to enamel mineral. Increasing the concentrations of mineral ions in dental plaque should therefore reduce its own caries-forming potential. Our previous study showed that 4-day plaque samples from young adults, associated with the lower anterior lingual site, which

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Section: Discussionsupporting

confidence: 84%

Site-specificity of mineral ions in 2-day dental plaque obtained from children and young adults

Hirose

Fukuda

Yahata

et al. 2010

Pediatric Dental Journal

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“…In previous studies MFPase activity of natural plaque has been found to be greater at or above pH 7 than below this value [Jackson, 1982;Bercy and Vreven, 1983]. Numerous other studies support the enzymic hydrolysis of MFP in plaque [Schamschula et al, 1985;Øgaard et al, 1985], although some suggest that hydrolysis is not rapid [Vogel et al, 2000].…”

Section: Discussionmentioning

confidence: 95%

“…In a mouthrinse trial, 500 mmol/l urea raised plaque pH to 8.3 within 1 min, when MFP was rapidly hydrolysed [Schamschula et al, 1985], and urea chewing gum has a strong plaque pH-raising effect [Dawes and Dibdin, 2001]. However, the possibility that urea may inhibit alkaline phosphatase should be kept in mind [Seiffert et al, 1984].…”

Section: Discussionmentioning

confidence: 99%

The Effect of pH, Temperature and Plaque Thickness on the Hydrolysis of Monofluorophosphate in Experimental Dental Plaque

Pearce¹,

Dibdin

2003

Caries Res

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Monofluorophosphate (MFP), an anti-caries agent commonly used in toothpaste, is known to be degraded to fluoride and orthophosphate by bacterial phosphatases in dental plaque. We have examined the effect of pH, temperature, plaque thickness and some ions on this process. Both natural plaque and artificial microcosm plaque incubated with purified MFP at pH 4–10 showed an optimum pH of ∼8 for hydrolysis. Diffusion and concomitant hydrolysis were examined in an apparatus in which artificial plaque was held between rigid membranes separating two chambers. When MFP diffused through a plaque of 0.51-mm thickness over 4 h it was almost completely hydrolysed at pH 8, but hydrolysis on diffusion decreased as the pH deviated from 8. MFP in toothpaste extract showed a similar pH susceptibility to hydrolysis, according to the inherent pH of the toothpaste. Hydrolysis of MFP in the toothpaste was reduced by no more than 10% when compared with a matched-pH control, suggesting that other toothpaste ingredients had no major influence on hydrolysis. Transport was slower and hydrolysis at pH 6 more complete the thicker the plaque, but hydrolysis was not significantly slower at 23°C than at 37°C. The addition of various potential activating or inhibiting ions at 0.1 and 1.0 mmol/l had small and non-significant effects on hydrolysis. The results suggest that MFP toothpaste should be formulated and used to maximise enzymic hydrolysis of this complex anion, and that plaque pH control is probably the most important factor.

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In vitro determination of the remineralizing potential and cytotoxicity of non-fluoride dental varnish containing bioactive glass, eggshell, and eggshell membrane

Durmuş

Kölüş

Coban

et al. 2023

Eur Arch Paediatr Dent

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Immediate and Delayed Effects of an Enzyme-dependent Mineralizing Mouthrinse on Dental Plaque

Cited by 7 publications

References 13 publications

Site-specificity of mineral ions in 2-day dental plaque obtained from children and young adults

Site-specificity of mineral ions in 2-day dental plaque obtained from children and young adults

The Effect of pH, Temperature and Plaque Thickness on the Hydrolysis of Monofluorophosphate in Experimental Dental Plaque

In vitro determination of the remineralizing potential and cytotoxicity of non-fluoride dental varnish containing bioactive glass, eggshell, and eggshell membrane

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