Immature platelet fraction in bacterial sepsis severity assessment

Djuang, Michelle Hendriani; Ginting, Franciscus; Hariman, Herman

doi:10.1088/1755-1315/125/1/012024

Cited by 6 publications

(7 citation statements)

References 10 publications

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“…Two studies reported that IPF cannot assess the severity of sepsis when compared with PCT. [ 3 12 ] De Blasi, et al . [ 4 ] reported that IPF was seen to be elevated two days before the onset of sepsis in critically ill patients in the ICU.…”

Section: Discussionmentioning

confidence: 99%

“…However, Sang Hyuk Park, et al .,[ 3 ] announced in his study that IPF can diagnose sepsis but not differentiate between complicated and noncomplicated sepsis. This was also reported by M. H Djuang, et al .,[ 12 ] that IPF when combined with PCT did not show significant results in assessing the severity of sepsis when compared with other platelet indices. Qin-hua Liu, et al .…”

Section: Discussionmentioning

confidence: 99%

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Role of immature platelet fraction (IPF) in sepsis patients: A systematic review

Tauseef

Zafar

Arshad

et al. 2021

J Family Med Prim Care

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Sepsis is extremely common amongst critically ill patients and requires early diagnosis. Hence, identifying a biomarker that could acknowledge sepsis at its prior stage is of vital significance. Immature platelets are a percentage of circulating platelets that contain RNA and is a newer parameter that is measured using automated hematology analyzers in diagnosing sepsis. This review article discusses 10 articles that reveal the role of immature platelet fraction in predicting the onset of sepsis and its relationship with mortality in sepsis. Literature search was done using PubMed, Scopus and Google Scholar and words like platelet indices and immature platelet fraction were typed in the search bar. The aim of this review article is to present a precise form of data that talk about immature platelet fraction (IPF) and its association with the severity and mortality of sepsis. Five out of 10 articles suggest that immature platelet fraction can predict the onset of sepsis and eight out of 10 articles suggest that increased IPF values are associated with high mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Role of immature platelet fraction (IPF) in sepsis patients: A systematic review

Tauseef

Zafar

Arshad

et al. 2021

J Family Med Prim Care

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“…Another study found that IPF was strongly positively correlated with MPV and PDW, and attributed this to an increase in the number of larger and wider platelets that appeared after the destruction of pro-inflammatory cytokines and endotoxins as part of a severe inflammatory response. 8 Together, these findings suggest that IPF levels increase in inflammatory diseases such as sepsis and may be used as an indicator of the inflammatory response. In our study, there were significant differences in inflammatory markers (IPF, MPV, PLT, and WBC) between acute bronchiolitis patients and healthy individuals.…”

Section: Discussionmentioning

confidence: 89%

“…Diagnostic accuracy studies performed over the last few years suggest that IPF levels can provide clinically relevant information regarding inflammatory activity and disease prognoses. [5][6][7][8] Here, we evaluate the relationship between changes in platelet parameters such as IPF and the clinical severity of acute bronchiolitis.…”

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confidence: 99%

The relationship between immature platelet fraction and severity of acute bronchiolitis

Doğan¹,

Köse²,

Öztürk³

et al. 2021

Turk J Pediatr

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Background and objectives. Acute bronchiolitis is one of the most common reasons for hospitalization in infants. Although patients with acute bronchiolitis generally have a good prognosis, death can also occur. In this study, we evaluate the immature platelet fraction (IPF) as an indicator of the severity of acute bronchiolitis.Methods. In our study, 179 patients diagnosed with acute bronchiolitis were divided into three groups as mild (n: 48; 26.8%), moderate (n: 104; 58.10%) and severe (n: 27; 15.1%) bronchiolitis. There were 80 healthy children in the control group. The diagnostic capacity of IPF and hematological parameters (platelet distribution width (PDW), mean platelet volume (MPV), white blood cell count (WBC), and platelet count (PLT)) values to predict severity of acute bronchiolitis was evaluated using receiver operating characteristic (ROC) curves and their respective areas under the curves (AUCs) calculated with 95% confidence intervals.Results. The IPF value of patients with acute bronchiolitis was significantly higher than the healthy group (p < 0.001). In addition, a positive correlation was observed between clinical severity of bronchiolitis and IPF. The ROC curve analysis indicated that the IPF cut-off point for predicting severity of acute bronchiolitis was >3.2% (Sensitivity of 84%, specificity of 97%). We found that the AUCs for IPF, MPV, PDW, WBC and PLT were statistically significant for bronchiolitis relative to the healthy control group. The parameter with the greatest AUC value was IPF. Conclusion.The IPF may present for diagnosing and evaluating the clinical severity of acute bronchiolitis in children.

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“…evaluated the IPF as a biomarker for sepsis diagnosis and severity and found that it was correlated with sepsis severity scores and had the highest diagnostic accuracy for sepsis among all the clinical and laboratory parameters assessed 14 . Another study found that IPF was strongly positively correlated with MPV and PDW, and attributed this to an increase in the number of larger and wider platelets that appeared after the destruction of pro-inflammatory cytokines and endotoxins as part of a severe inflammatory response 15 . Together, these findings suggest that IPF levels increase in inflammatory diseases such as sepsis and may be used as an indicator of the inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

The relationship of the immature platelet fraction with the diagnosis and severity of acute bronchiolitis in children.

Doğan

Köse

Öztürk

et al. 2020

Preprint

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Objective: Acute bronchiolitis is one of the most common causes of hospitalization for children younger than 1 year. Although the prognosis for these children is generally good, the condition involves a risk of mortality. Here, we evaluate the immature platelet fraction (IPF) as a biomarker for the severity of acute bronchiolitis. Material and Methods: In total, 179 children who had been diagnosed with acute bronchiolitis were classified into three groups: mild, moderate, and severe bronchiolitis, and 80 healthy children were included as a control group. The diagnostic capacity of the IPF, mean platelet volume (MPV), platelet distribution width (PDW), white blood cell count (WBC), and platelet count (PLT) values to predict bronchiolitis was evaluated using receiver operating characteristic (ROC) curves and their respective areas under the curves (AUCs) calculated with 95% confidence intervals. Results: Patients with acute bronchiolitis had a larger IPF than their healthy counterparts (p < 0.001). Additionally, a positive correlation was observed between the clinical severity of the disease and the IPF. The ROC curve analysis indicated that the IPF cut-off point for predicting acute bronchiolitis was >3.2%, with a sensitivity of 84% and specificity of 97%. Our results clearly demonstrate that the AUCs for IPF, MPV, PDW, WBC, and PLT were statistically significant for the bronchiolitis versus the control group. The AUC was greatest for the IPF. Conclusion: The IPF is a new marker for diagnosing and evaluating the clinical severity of acute bronchiolitis.

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Immature platelet fraction in bacterial sepsis severity assessment

Cited by 6 publications

References 10 publications

Role of immature platelet fraction (IPF) in sepsis patients: A systematic review

Role of immature platelet fraction (IPF) in sepsis patients: A systematic review

The relationship between immature platelet fraction and severity of acute bronchiolitis

The relationship of the immature platelet fraction with the diagnosis and severity of acute bronchiolitis in children.

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