Immature platelet dynamics in management of protracted response to therapy of a young pediatric patient with immune-mediated thrombotic thrombocytopenic purpura

Pathological Mechanisms and Novel Testing Methods in Thrombotic Thrombocytopenic Purpura

“…It should be noted that A-IPC monitoring also seems to correlate with the course of recovery and presence of relapse in pediatric iTTP patients, and A-IPC returning to baseline after increasing during therapy is evidence that recovery has occurred [ 8 , 12 , 35 , 40 , 41 ]. Consequently, in critically ill pediatric iTTP patients who require timely biomarkers for disease progression or lack thereof, A-IPC, if monitored regularly, has the potential to be of use under such circumstances [ 41 ].…”

“…Reversal occurs more quickly, even after a single procedure, in patients with a high inhibitor to ADAMTS13. Additionally, even when length of stay is taken into account, high inhibitor patients require a greater number of TPE procedures to overcome their disease, stabilize their platelet count, and achieve remission in both adult and pediatric settings [ 8 , 41 ].…”