Immature Citrus sunki Peel Extract Exhibits Antiobesity Effects by .BETA.-Oxidation and Lipolysis in High-Fat Diet-Induced Obese Mice

Kang, Seong-Il; Shin, Hye-Sun; Kim, Hyo-Min; Hong, Youn-Suk; Yoon, Seon-A; Kang, Seung-Woo; Kim, Jeong‐Hwan; Kim, Moo-Han; Ko, Hee-Chul; Kim, Se-Jae

doi:10.1248/bpb.35.223

Cited by 79 publications

(68 citation statements)

References 27 publications

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“…17 The extract was administered orally at a dose of 150 mg/kg per day for 70 days. Body weight gain, adipose tissue weight, serum total cholesterol, and triglycerides decreased significantly relative to animals fed the normal diet as well as the high-fat diet.…”

Section: Discussionmentioning

confidence: 99%

Increased eating control and energy levels associated with consumption of bitter orange (<em>p</em>-synephrine) extract: a randomized placebo-controlled study

Kaats¹,

Leckie²,

Mrvichin³

et al. 2017

NDS

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Using a placebo-controlled double-blinded 30-day protocol, 40 overweight adults were asked to consume a chocolate-flavored chew 15-30 min before their two largest meals of the day. The chews contained either a placebo or an "active" product (100 mg of a bitter orange extract, standardized to 51.5 mg p-synephrine). Subjects completed a 13-item Weight Control Support Scale (WCSS) containing eating control, energy level, and palatability subscales daily throughout the study. All 40 subjects completed the study. No adverse effects were reported in either the placebo or active groups. As compared to placebo, subjects consuming the active product reported statistically more (p≤0.001) positive responses on the WCSS as well as on each of the three subscales. This study suggests that, as compared to a placebo control, consuming a chew containing bitter orange extract (51.5 mg p-synephrine) 15-30 min before the two largest meals of the day resulted in a statistically significant greater and more positive response to eating/appetite control and a weight-control support scale.

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Section: Discussionmentioning

confidence: 99%

Increased eating control and energy levels associated with consumption of bitter orange (<em>p</em>-synephrine) extract: a randomized placebo-controlled study

Kaats¹,

Leckie²,

Mrvichin³

et al. 2017

NDS

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“…ex Tanaka peel extract was isolated as described previously [9]. Total RNA was isolated using easy blue kit and RT-PCR reaction was carried out by Maxime RT-PCR PreMix kit.…”

Section: Methodsmentioning

confidence: 99%

“…Following a report analyzing the composition of Citrus peel, the peel of Citrus sunki Hort. ex Tanaka is a rich source of polymethoxylated flavones [9]. A number of biological activities of polymethoxylated flavonoids isolated from Citrus sunki Hort.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Citrus sunki Peel Extract on Matrix Metalloproteinase-1 Expression

Han¹,

Lee

2013

Journal of Life Science

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Flavonoids are one of the major components found in the peels of citrus fruits. Present evidence has suggested that polymethoxyflavonoids, including nobiletin and tangeretin isolated from Citrus sunki, have many biological properties, such as anti-inflammatory, anti-oxidant, and anti-obesity capabilities.Here, we investigated the effect of Citrus sunki peel extract and its possible mechanisms on oxidative stress-induced MMP-1 expression, a major marker of skin photoaging. H2O2 induced MMP-1 expression in a dose-and time-dependent manner. Extract of Citrus sunki peel (1-25 μg/ml) dose-dependently decreased MMP-1 mRNA levels. When H2O2 was combined with Citrus sunki peel extract, the phosphorylation of ERK was further decreased compared to a single treatment with H2O2 alone. Moreover, U0216, an MEK inhibitor, markedly prevented the production of MMP-1. These data suggest that Citrus sunki peel extract has demonstrated protective activity against oxidative damage on MMP-1 expression, and ERK MAP kinase may be involved.

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“…ex TANAKA, have anti-obesity properties in high-fat-diet-induced obese mice. 12,13) We previously described eight PMFs from C. sunki. 14) Among these, two common PMFs (nobiletin and tangeretin) have been reported to modulate lipid metabolism.…”

mentioning

confidence: 99%

Sinensetin Enhances Adipogenesis and Lipolysis by Increasing Cyclic Adenosine Monophosphate Levels in 3T3-L1 Adipocytes

Kang

Shin

Kim

2015

Biological & Pharmaceutical Bulletin

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Immature Citrus sunki Peel Extract Exhibits Antiobesity Effects by .BETA.-Oxidation and Lipolysis in High-Fat Diet-Induced Obese Mice

Cited by 79 publications

References 27 publications

Increased eating control and energy levels associated with consumption of bitter orange (<em>p</em>-synephrine) extract: a randomized placebo-controlled study

Increased eating control and energy levels associated with consumption of bitter orange (<em>p</em>-synephrine) extract: a randomized placebo-controlled study

Effects of Citrus sunki Peel Extract on Matrix Metalloproteinase-1 Expression

Sinensetin Enhances Adipogenesis and Lipolysis by Increasing Cyclic Adenosine Monophosphate Levels in 3T3-L1 Adipocytes

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