Imipramine Therapy in Depressive Syndromes: Prediction of Therapeutic Outcome

Wilson, Ian C.; Rabon, Archie M.; Buffaloe, William J.

doi:10.1016/s0033-3182(67)71978-7

Cited by 14 publications

(5 citation statements)

References 35 publications

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“…The literature on gender differences in response to antidepressant treatment is particularly sparse and fraught with methodological difficulties (Dawluns and Potter, 1991;Yonkers et al, 1992). Nonetheless, as noted above, several studies have indicated that women may be less likely than men to respond to imipramine (Prange, 1972;Perel et al, 1977;Raskm, 1974;Wilson et al, 1967;Davidson and Pelton, 1986). Possible gender differences in response to other somatic antidepressant treatments have not been studied.…”

Section: Discussionmentioning

confidence: 99%

Gender differences in seasonal affective disorder

1995

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The purpose of this study was to ascertain whether men and women with seasonal affective disorder (SAD) differ in their clinical presentation or in their response to bright light therapy. Data from all patients who participated in our SAD clinic between 1981 and 1991 were analyzed retrospectively. A linear discriminant function analysis was performed using self‐report data from the Seasonal Pattern Assessment Questionnaire and the Seasonal Screening Questionnaire (N =167 women and 43 men). SIGH‐SAD ratings (consisting of the Hamilton Depression Rating Scale and an addendum for atypical symptoms) were analyzed to determine if men and women differed in clinician‐rated symptoms at baseline (N = 86 women and 28 men), or in their response to phototherapy (N =43 women and 16 men). Male and female SAD patients did not differ in clinician‐rated symptoms or in their response to phototherapy. However, on self‐report scales, men reported more severe illness, while women reported more carbohydrate craving, a greater percentage increase in weight, and more hours of sleep per night in the winter. The linear discriminant function analysis correctly classified 93.4% of the women but only 27.9% of the men. Since we found significant differences only on self‐report scales, our results may reflect a gender difference in symptom reporting. Alternatively, our findings may reflect gender differences in depressive symptomatology or differences between normal men and women in the sleep‐wake cycle or in carbohydrate craving. Men with SAD may have a more heterogeneous presentation than women with SAD. There is, however, no gender difference in response to phototherapy. Depression 3:13–19 (1995). © 1995 Wiley‐Liss, Inc .

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Section: Discussionmentioning

confidence: 99%

Gender differences in seasonal affective disorder

1995

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“…The Clinical Psychiatry Committee of the British Medical Research Council Report (1965) reported a better male response to imipramine. This was substantiated by Wilson (1967). On the other hand, Prange et al (1972) reported that efficacy of L-triidothyronine (T3) in acceler ating the antidepressant response of imipramine was limited to women only.…”

Section: (B) Age and Sexmentioning

confidence: 89%

Clinical Prediction of Antidepressant Response

Ananth¹

1978

Int Pharmacopsychiatry

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Depression is not a unitary disease and not all cases of depression can be treated alike. Therefore, predictors of antidepressant response to different drugs need to be identified. Premorbid personality, age and sex and family history are useful in prediction. As an example, only females respond to the addition of triiodothyronine to the antidepressant therapy. Endogenous depressions respond favourably to antidepressants, so also do psychotic depressions. On the other hand, delusional depressions do not respond to antidepressants. While atypical depressions are best treated with MAOI, motor retardation improves with imipramine and obsessive symptoms with chlorimipramine. In addition to clinical variables, biochemical and statistical approaches have also yielded significant results in prediction.

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“…An early study of 250 depressed patients by the Medical Research Council reported that imipramine is more effective in men than in women. 45 A study of 60 depressed inpatients also found that men responded better to imipramine, 148 as did a 4-week study of 55 depressed inpatients treated with imipramine 149 and a. large study of 200 patients on imipramine. 150 More recently, a. study of 230 depressed patients also described imipramine therapy as more effective in men.…”

Section: Pharmacodynamicsmentioning

confidence: 96%

Sex-dependent modulation of treatment response

Rubinow

Moore

2004

Dialogues in Clinical Neuroscience

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The response to a psychotropic medication reflects characteristics of both the medication and the substrate, ie, the individual receiving the medication. Sex is an individual characteristic that influences all elements of the pharmacokinetic process - absorption, distribution, metabolism, and elimination. The effects of sex on these components of the pharmacokinetic process often counterbalance one another to yield minimal or varying sexual differences in blood levels achieved. However, sex also appears to influence pharmacodynamics, the tissue response to a given level of medication. Consideration by the practitioner of sex as a possible contributing factor to treatment nonresponse will enhance the efficacy and precision of clinical interventions.

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Imipramine Therapy in Depressive Syndromes: Prediction of Therapeutic Outcome

Cited by 14 publications

References 35 publications

Gender differences in seasonal affective disorder

Gender differences in seasonal affective disorder

Clinical Prediction of Antidepressant Response

Sex-dependent modulation of treatment response

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