Imipramine for vestibular dysfunction in panic disorder: a prospective case series

Mezzasalma, Marco A.; Mathias, K; Nascimento, Isabella; Valença, Alexandre Martins; Nardi, Antônio Egídio

doi:10.1590/s0004-282x2011000200011

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…A prospective case series including 9 Is-PD with chronic dizziness found improvement in panic symptoms, dizziness, and some otoneurologic parameters, after 3-month treatment with imipramine. These favorable effects of imipramine, which has serotonergic properties, were thought to be related to the well-known involvement of serotonergic pathways in both panic and balance system regulation 99,103. In line with this, in a mixed sample of patients with dizziness, vestibular abnormalities, and psychiatric disorders, including a large portion of Is-PD, SSRIs relieved dizziness to a greater extent than vestibular suppressants or BDZ 104.…”

Section: Phenomenological Profilesmentioning

confidence: 89%

<p>Toward a personalized therapy for panic disorder: preliminary considerations from a work in progress</p>

Caldirola¹,

Perna²

2019

NDT

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Although several treatment options for panic disorder (PD) are available, the best intervention for each individual patient remains uncertain and the use of a more personalized therapeutic approach in PD is required. In clinical practice, clinicians combine general scientific information and personal experience in the decision-making process to choose a tailored treatment for each patient. In this sense, clinicians already use a somehow personalized medicine strategy. However, the influence of their interpretative personal models may lead to bias related to personal convictions, not sufficiently grounded on scientific evidence. Hence, an effort to give some advice based on the science of personalized medicine could have positive effects on clinicians’ decisions. Based on a narrative review of meta-analyses, systematic reviews, and experimental studies, we proposed a first-step attempt of evidence-based personalized therapy for PD. We focused on some phenomenological profiles, encompassing symptoms during/outside panic attacks, related patterns of physiological functions, and some aspects of physical health, which might be worth considering when developing treatment plans for patients with PD. We considered respiratory, cardiac, vestibular, and derealization/depersonalization profiles, with related implications for treatment. Given the extensiveness of the topic, we considered only medications and some somatic interventions. Our proposal should be considered neither exhaustive nor conclusive, as it is meant as a very preliminary step toward a future, robust evidence-based personalized therapy for PD. Clearly much more work is needed to achieve this goal, and recent technological advances, such as wearable devices, big data platforms, and the application of machine learning techniques, may help obtain reliable findings. We believe that combining the efforts of different research groups in this work in progress can lead to largely shared conclusions in the near future.

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Section: Phenomenological Profilesmentioning

confidence: 89%

<p>Toward a personalized therapy for panic disorder: preliminary considerations from a work in progress</p>

Caldirola¹,

Perna²

2019

NDT

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“…Флувоксамин (200 мг/сут) и милнаципран (50 мг/сут) купируют не только тревогу и депрессию, но и выраженность ощущения ГК у больных с хроническим ГК [66,67]. У пациентов с ПА и ГК в межприступном периоде был достигнут положительный эффект в отношении субъективного ГК при терапии имипрамином (50-100 мг/сут) [68] и пароксетином (20 мг/сут) [44]. У пациентов с депрессией и ГК в качестве главной соматической жалобы назначение пароксетина по 20 мг/сут через 4-8 нед лечения приводило к значительному улучшению состояния [69].…”

Section: фармакотерапияunclassified

Functional (psychogenic) vertigo

Diukova

Замерград

Golubev

et al. 2017

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Psychogenic (functional) vertigo is in second place by frequency after benign positional paroxysmal vertigo. It is often difficult to make the diagnosis, diagnostic program is expensive and traditional treatment often is not effective. This literature review covers current concepts on the terminology, clinical signs, pathogenesis and treatment approaches with regard to functional vertigo. Special attention is given to cerebral mechanisms of the pathogenesis including cognitive aspects.

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Panic Disorder, Is It Really a Mental Disorder? From Body Functions to the Homeostatic Brain

Perna¹,

Iannone²,

Torti³

et al. 2016

Panic Disorder

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Imipramine for vestibular dysfunction in panic disorder: a prospective case series

Cited by 4 publications

References 19 publications

<p>Toward a personalized therapy for panic disorder: preliminary considerations from a work in progress</p>

<p>Toward a personalized therapy for panic disorder: preliminary considerations from a work in progress</p>

Functional (psychogenic) vertigo

Panic Disorder, Is It Really a Mental Disorder? From Body Functions to the Homeostatic Brain

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